A Spiking Model of Hippocampus for Guiding Behavior

指导行为的海马尖峰模型

• 批准号: 6668485
• 负责人: Michael E Hasselmo
• 金额: $ 24.38万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6668485
• 关键词: action potentials; behavior test; behavioral /social science research tag; computational neuroscience; computer human interaction; computer program /software; computer simulation; computer system design /evaluation; electroencephalography; electrophysiology; entorhinal cortex; goal oriented behavior; hippocampus; interdisciplinary collaboration; memory; model design /development; motivation; neural transmission; neurophysiology; prefrontal lobe /cortex; tegmentum

DESCRIPTION (provided by applicant): The proposed research focuses on development of a detailed and realistic model of how neural firing patterns in the hippocampus, entorhinal cortex, prefrontal cortex and ventral tegmental area mediate goal directed behavior in specific behavioral tasks. These projects explore the interaction of goal activation, response selection and episodic memory for guiding behavior. Understanding these processes of motivated behavior should prove important for understanding the drug addiction processes. In particular this work allows modeling of how alterations in glutamatergic, GABAergic cholinergic and dopaminergic processes within numerous interacting regions could influence addictive behavior. The proposed research will further develop existing software that allows a direct interface between a neural simulation and behavior of a virtual rat in a virtual environment, a model simultaneously constrained by requirements about behavioral function and biologically realistic structure. The neural simulation uses dynamics based on extensive physiological data on rhythmic field potentials (EEG) and firing patterns of individual neurons (unit recording). The research proposed here will involve a continuous interaction between three groups: 1. The group in Edinburgh (Robert Cannon and Nigel Goddard) will provide ongoing development of a flexible, graphics based simulation package (CATACOMB), which allows construction of neural simulations for guiding behavior of a virtual rat in a variety of different experimental tasks, including spatial memory tasks and operant tasks. 2. The Hasselmo group will continue development of simulations of how the hippocampus, entorhinal cortex, prefrontal cortex and ventral tegmental area are involved in goal directed movements in behavioral tasks. This work will generate clear experimental predictions about the timing of spikes relative o behavior and relative to theta rhythm EEG based on hypotheses about the physiological interaction. 3. The Eichenbaum group will analyze data from a spatial alternation task to test specific predictions of the simulation about the timing of spikes during behavior. This project will have a synergistic interaction with a separate collaboration between the Hasselmo and Kantak laboratories at B.U., which focuses on modeling operant tasks used in experimental studies of drug self-administration phenomena, in work supported by a supplement to a previous grant from NIDA.

描述（由申请人提供）：拟议的研究重点是开发一个详细且现实的模型，该模型是如何在海马，内嗅皮层，前额叶皮层和腹侧段区域中如何调解特定行为任务中的目标行为。这些项目探讨了指导行为的目标激活，响应选择和情节记忆的相互作用。了解这些动机行为的这些过程对于理解药物成瘾过程至关重要。特别是这项工作允许建模谷氨酸能，GABA能胆碱能和多巴胺能在众多相互作用区域内如何影响成瘾行为。拟议的研究将进一步开发现有的软件，该软件允许在虚拟环境中神经模拟与虚拟大鼠的行为之间的直接接口，这是一个模型，同时受到对行为函数和生物学现实结构的要求的约束。神经模拟使用基于节奏场电位（EEG）（EEG）和单个神经元（单位记录）的发射模式的大量生理数据使用动力学。这里提出的研究将涉及三组之间的持续相互作用： 1。爱丁堡（罗伯特·坎农（Robert Cannon）和奈杰尔·戈达德（Nigel Goddard））的小组将提供基于图形的仿真软件包（catacomb）的持续开发，该软件包允许在包括空间内存任务和操作范围任务在内的各种不同的实验任务中构建神经模拟，以指导虚拟大鼠的行为。 2。Hasselmo组将继续开发有关海马，内嗅皮层，前额叶皮层和腹侧盖区域如何参与行为任务中的目标定向运动的模拟。这项工作将基于关于生理相互作用的假设，对峰值相对行为的时机以及相对于theta节奏的脑电图的时机产生明确的实验预测。 3。Eichenbaum组将分析来自空间交替任务的数据，以测试有关行为过程中峰值时间的模拟的特定预测。 该项目将与B.U. Hasselmo和Kantak实验室之间的单独合作进行协同互动，该项目的重点是建模用于药物自我管理现象的实验研究中使用的操作任务，这是由NIDA先前拨款的补充工作支持的工作。