Core C: Data Management and Statistical Core

核心C：数据管理与统计核心

• 批准号: 10472766
• 负责人: Sue E. Leurgans
• 金额: $ 37.13万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10472766
• 关键词: Alzheimer disease prevention; Alzheimer' s Disease; Alzheimer' s disease related dementia; Biochemical; Clinical; Collaborations; Communities; Data; Data Collection; Data Element; Data Set; Database Management Systems; Databases; Development; Diagnosis; Dictionary; Documentation; Equipment and supply inventories; Etiology; Foundations; Funding; Generations; Goals; Grant; Industry; Latino; Maintenance; Molecular; Online Systems; Outcome; Participant; Pathogenesis; Process; Publications; Reporting; Research; Research Personnel; Resource Sharing; Resources; Schedule; Secure; Services; Specimen; Statistical Computing; Summary Reports; Support System; System; Time; United States National Institutes of Health; data hub; data management; data sharing; design; education research; electronic data; flexibility; image processing; improved; innovation; neuroimaging; neuroimaging marker; neuropathology; normal aging; open data; operation; outreach; recruit; relational database; religious order study; repository; secondary analysis; statistical service; statistics; success; tool; web site

ABSTRACT – DATA MANAGEMENT AND STATISTICAL CORE The Data Management and Statistical Core (Data/Stat Core) of the proposed Rush ADRC will design and maintain systems to support the acquisition, maintenance, distribution and analysis of high-quality data to be collected by the Clinical, Religious Orders Study, Latino, and Neuropathology Cores of the ADRC and the processing of image files by the Biomarker/Neuroimaging Core. These data will be a resource for research on normal aging, MCI, Alzheimer’s Disease, and Alzheimer’s Disease-Related Dementias (AD/ADRD). The Data Management and Statistical Core will support the other cores in the Center by (1) maintaining a center-wide system of random subject ID numbers, (2) maintaining PC- and web-based electronic data collection systems for each core to collect data, (3) processing and maintaining item-level data in a secure relational database management system, (4) managing storage of high throughput files containing biochemical and molecular data, (5) storing computed summary variables in a secure relational database management system, (6) providing flexible, comprehensive, automatic and timely status reports for study coordination, and (7) designing, maintaining and tracking usage of the Center’s internal and external websites. The Data/Stat Core will also maintain tracking systems for (1) scheduling and prioritizing study participants and biospecimens for the Clinical, Religious Order Study, and Latino Cores, (2) tracking biospecimen inventory and requests for distributions for the Neuropathology and Administrative Cores, (3) tracking data requests and distributions for the Administrative Core, (4) tracking activities and outcomes for the Outreach, Recruitment, and Engagement Core and for the Research Education Component, (5) tracking publications using Rush ADRC resources, and (6) prioritization of data management and statistics activities. The Core will provide expert statistical assistance with design and analysis to Rush ADRC investigators and developmental project applicants and awardees, and more limited guidance to independently funded studies that utilize Rush ADRC data and/or specimens. The Core will support systems for providing data and biospecimens to NIA-sponsored repositories (such as NACC, NCRAD, NIAGADS, AMP-AD) and to externally funded projects and secondary analyses, with an emphasis on projects funded by the National Institutes of Health and other reputable research organizations. The Data/Stat Core will maintain an online system for investigators inside or outside the Rush ADRC to submit requests for Rush ADRC data and biospecimens. The Core will maintain tools that extract approved datasets for distribution, and generate accompanying clear and accurate data element dictionaries so as to support open science and innovative research on the etiology, pathogenesis, diagnosis, treatment and prevention of Alzheimer’s disease and Alzheimer's disease-related dementias (AD/ADRD).

摘要 – 数据管理和统计核心 拟议 Rush ADRC 的数据管理和统计核心（Data/Stat Core）将设计和 维护系统以支持高质量数据的获取、维护、分发和分析 由 ADRC 和 ADRC 的临床、宗教研究、拉丁裔和神经病理学核心收集 通过生物标记/神经成像核心处理图像文件这些数据将成为研究资源。 正常衰老、MCI、阿尔茨海默病和阿尔茨海默病相关痴呆 (AD/ADRD)。 数据管理和统计核心将通过以下方式支持中心的其他核心：(1) 维护 中心范围内的随机受试者 ID 号系统，(2) 维护基于 PC 和网络的电子数据 每个核心的收集系统收集数据，（3）以安全的方式处理和维护项目级数据 关系数据库管理系统，（4）管理包含生化物质的高吞吐量文件的存储 和分子数据，(5) 将计算出的汇总变量存储在安全的关系数据库管理中 系统，（6）为研究协调提供灵活、全面、自动、及时的状态报告，以及 (7) 设计、维护和跟踪中心内部和外部网站的使用情况。 Core 还将维护跟踪系统，用于 (1) 安排和优先考虑研究参与者和生物样本 对于临床、宗教秩序研究和拉丁裔核心，(2) 跟踪生物样本库存和请求 神经病理学和管理核心的分布，(3) 跟踪数据请求和分布 行政核心，(4) 跟踪外展、招聘和参与的活动和结果 研究教育的核心部分，(5) 使用 Rush ADRC 资源跟踪出版物，以及 (6) 数据管理和统计活动的优先顺序。 核心将为 Rush ADRC 调查人员提供设计和分析方面的专家统计协助， 发展项目申请人和获奖者，以及对独立资助研究的更有限的指导 利用 Rush ADRC 数据和/或样本。 该核心将支持向 NIA 赞助的存储库提供数据和生物样本的系统（例如 NACC、NCRAD、NIAGADS、AMP-AD）以及外部资助的项目和二次分析， 重点关注由美国国立卫生研究院和其他知名研究组织资助的项目。 数据/统计核心将维护一个在线系统，供 Rush ADRC 内部或外部的调查人员提交 对 Rush ADRC 数据和生物样本的请求 核心将维护提取批准数据集的工具。 进行分发，并生成配套的清晰、准确的数据元素字典，以支持 病因、发病机制、诊断、治疗和预防的开放科学和创新研究 阿尔茨海默病和阿尔茨海默病相关痴呆（AD/ADRD）。