STATISTICS AND DATA MANAGEMENT CORE

统计和数据管理核心

• 批准号: 6481371
• 负责人: Sue E. Leurgans
• 金额: $ 12.74万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6481371
• 关键词: biomedical facility; cognition disorders; computer program /software; data collection; data collection methodology /evaluation; data management; human data; neuropathology; statistics /biometry

DESCRIPTION (provided by applicant): The proposed Statistics and Data Management Core for the Program Project will provide the computational and analytic resources for successful data collection, storage, linkage, and analysis for all projects in the Program Project. The proposed core will have both data management component and a statistical analysis component. The goals of the data management portion of the core include: 1) development of direct computer entry programs for the neuropathology data, 2) facilitation of transmission of computer-generated laboratory results, and 3) establishment and maintenance of a database library linking all projects. The statistical responsibilities of the core will include providing design advice and statistical programming, and providing methodologic expertise on specific questions arising from the use of longitudinal studies with multiple measures of cognitive impairment. The research goals of this Program Project present complexities and challenges both in the management and in the analysis of the data. First, data management will be complicated because of the large quantity of data in varied formats from the separate sites, the longitudinal nature of the study designs of the need to link data from multiple times of observation and multiple studies within the core. The analysis of longitudinal data requires sophisticated methodology to characterize patterns of change in each person, to model similarities and differences across groups of people, and to look for associations between change in one measure and change in another between clinical change and post-mortem neuropathobiologic findings. This Core will provide expert support from a statistical research team experienced in the conduct of longitudinal studies.

描述（由申请人提供）：拟议的统计数据和数据 该计划项目的管理核心将提供计算和 用于成功数据收集、存储、链接和分析的分析资源 对计划项目中的所有项目进行分析。拟议的核心将具有 数据管理组件和统计分析组件。这 核心数据管理部分的目标包括： 1) 开发神经病理学数据的直接计算机输入程序， 2) 促进计算机生成的实验室结果的传输，以及 3）建立和维护连接所有项目的数据库库。 核心的统计职责将包括提供设计 建议和统计规划，并提供方法学专业知识 使用多个纵向研究产生的具体问题 认知障碍的测量。 该计划项目的研究目标存在复杂性和挑战 无论是在管理上还是在数据分析上。一、数据管理 由于数据量大、格式各异，会变得很复杂 从不同的地点来看，研究设计的纵向性质 需要链接多次观察和多项研究的数据 核心内。纵向数据分析需要复杂的 描述每个人变化模式的方法，建立模型 不同人群之间的相似点和差异，并寻找 一项措施的变化与另一项措施的变化之间的关联 临床变化和死后神经病理生物学发现。该核心将 由经验丰富的统计研究团队提供专家支持 进行纵向研究。