T32 Training Grant in Translational Immunology

T32 转化免疫学培训补助金

• 批准号: 10470893
• 负责人: Anne Davidson
• 金额: $ 35.27万
• 依托单位: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10470893
• 关键词: Grant; Immunology; Training

This new T32 program is designed to provide a rigorous training program in translational immunology for 2 pre-doctoral and one post-doctoral candidate. It will recruit a diverse cadre of young scientists to careers in immune disease-focused investigation and equip them for success. An increasing awareness of the role of the immune system in multiple diseases, coupled with technologic advances that allow analysis of microscopic quantities of human specimens have fueled exponential growth in the exploration and understanding of human immunopathologic conditions. Nevertheless, effective therapies for many immune disorders are still lacking. Highly motivated individuals completing training programs in immunology, particularly physician-scientists, are needed to enable rigorous and creative advances in biomedical research that will enhance our understanding of disease pathogenesis and suggest strategies to improve the outcome of patients with immune disorders. Our proposal engages 21 mentors at all career levels and is built around 4 areas of scientific excellence in immunology: 1) Autoimmunity; 2) Neuroimmune inflammation; 3) Tissue injury, inflammation and innate immunity and 4) Tumor immunology. In each area, our faculty investigate disease mechanisms using specimens from well-established clinical cohorts and biorepositories and perform human- relevant studies that range from focused studies in model organisms to clinical trials of novel therapies. Specific aims are: 1. To recruit trainees who are diverse with respect to demographics, experience and interests; 2. To provide a multi-disciplinary “toolbox” curriculum needed for a successful career in human and translational investigation; 3. To teach trainees how to conduct creative, rigorous and ethical independent research that is driven by observations in human disease and that uses state of the art technologies to generate and test new hypotheses related to immune mediated diseases; 4. To engage faculty, students and our advisory committee in an ongoing self-evaluation process that will foster the continued growth and improvement of our training program; 5. To mentor and create a new generation of translational immunologists who will collaboratively tackle research problems linked to improving clinical outcomes of patients with immune- mediated diseases. By combining existing courses that are part of the established infrastructure of the Elmezzi Graduate Program in Molecular Medicine and the Zucker School of Medicine at Hofstra University-Northwell Health with new curricular elements designed for this training program, including programs in leadership, conflict resolution, resilience and more, we can provide an enriched and motivating experience for our trainees. In this fashion we will develop physician- scientists and translational investigators who are focused on human disease and equipped with a broad understanding of immunology, modern technologies and the resilience to persevere.

该新的T32计划旨在提供翻译的严格培训计划 2个前博士后和1名候选人的免疫学。它将招募一个潜水员的干部 年轻的科学家从事以免疫疾病为中心的调查的职业，并为其装备 成功。对免疫系统在多种疾病中的作用的认识越来越多， 再加上技术进步，可以分析微观的人类 标本在人类的探索和理解中促进了指数的增长 免疫病理条件。然而，许多免疫疾病的有效疗法是 仍然缺乏。高度积极进取的人完成免疫学培训计划， 尤其是身体科学家，需要在 生物医学研究将增强我们对疾病发病机理的理解，并暗示 改善免疫疾病患者结果的策略。我们的提案参与21 各个职业级别的导师，建于四个在4个领域的科学卓越领域：1） 自身免疫性； 2）神经免疫注射； 3）组织损伤，注射和先天性 免疫学和4）肿瘤免疫学。在每个领域，我们的教师研究疾病机制 使用公认的临床队列和生物座席的标本，并进行人类 从模型生物的重点研究到新颖的临床试验的相关研究 疗法。具体目的是： 1。在人口统计，经验和兴趣方面招募潜水员； 2。提供成功职业生涯所需的多学科“工具箱”课程 并翻译调查； 3。教学员如何进行创造性，严格和道德独立研究 由人类疾病的观察和使用最先进的技术产生的状态的驱动 并检验与免疫介导的疾病有关的新假设； 4。让教师，学生和我们的咨询委员会进行持续的自我评估 流程将促进我们的培训计划的持续增长和改进； 5。精神并创建新一代的翻译免疫学家 解决有关改善免疫患者临床结果的研究问题 介导的疾病。 通过结合现有课程，这些课程是Elmezzi已建立的基础设施的一部分 Hofstra的分子医学研究生课程和扎克医学院 University-Northwell Health具有为该培训计划设计的新课程元素， 包括领导力的计划，解决冲突，韧性等，我们可以提供 我们的学员丰富而激励的经历。以这种方式，我们将发展物理 - 专注于人类疾病的科学家和翻译研究人员 对免疫学，现代技术和坚持不懈的韧性的广泛理解。