Etiology and outcome of MIS-C

MIS-C 的病因和结果

基本信息

批准号：
10198501
负责人：
Anne Davidson
金额：
$ 149.19万
依托单位：
FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-27 至 2024-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10198501
关键词：
2019-nCoV Acute Acute Disease Affinity Alleles Antibodies Antibody Repertoire Antibody Response Blood Blood specimen COVID-19 Caring Child Childhood Clinical Control Groups DNA Diagnosis Disease Enrollment Etiology Exhibits Fc Receptor Genes Goals Health High Pressure Liquid Chromatography Hospitalization Immune Complex Diseases Immunity Immunoglobulin G Immunoglobulin M Infection Inflammation Mediators Inflammatory Interferons Lead Length of Stay Mass Spectrum Analysis Mediating Modeling Mucocutaneous Lymph Node Syndrome Myocardial dysfunction Onset of illness Outcome Pathology Pathway interactions Patients Plasma Population Production Proteins Renin-Angiotensin System Risk Schools Serologic tests Serum Structure of germinal center of lymph node Syndrome Testing Up-Regulation Viral Antibodies Virus acute infection base cohort cytokine genetic analysis heart damage heart function immune activation macrophage metabolic profile metabolomics neutralizing antibody neutrophil pandemic disease pediatric patients receptor binding response risk variant seropositive young adult

项目摘要

Abstract This proposal seeks to test two hypotheses regarding the Multisystem Inflammatory Syndrome (MIS-C) recently identified in children and young adults infected with SARS-CoV-2. We hypothesize that there is a spectrum of disease from severe acute disease to MIS-C. Severe Cov acute disease is associated with low interferon production, poor control of virus and a germinal center derived antibody response to the virus leading to long term immunity while MIS- C is associated with high interferon, efficient control of virus, but an extrafollicular derived antibody response with poor long term immunity. We will test this hypothesis through a genetic analysis, analysis of serum cytokines and analysis of anti-viral antibodies. We also hypothesize that plasma metabolic profile of subjects with MIS-C will predict short term cardiac dysfunction and long term cardiac damage.

抽象的该提案旨在检验有关多系统炎症综合征的两个假设（MIS-C）最近在感染SARS-COV-2的儿童和年轻人中发现了。我们假设从严重的急性疾病到MIS-C有很多疾病。严重 COV急性疾病与干扰素的产生低，对病毒的控制不良和A 生发中心衍生出对病毒的抗体反应，导致长期免疫力，而错误 C与高干扰素，有效控制病毒有关，但是衍生出毛囊长期免疫力较差的抗体反应。我们将通过遗传来检验该假设分析，血清细胞因子分析和抗病毒抗体的分析。我们也假设 MIS-C受试者的血浆代谢概况可以预测短期心脏功能障碍和长期心脏损伤。