Using Neuroeconomics to Understand Alcohol Overvaluation in Alcohol Use Disorder

利用神经经济学来理解酒精使用障碍中酒精的高估

基本信息

批准号：
10456844
负责人：
JAMES MACKILLOP
金额：
$ 23.9万
依托单位：
UNIVERSITY OF GEORGIA
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-05 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10456844
关键词：
Acute Address Affect Alcohols Animal Model Animals Anterior Area Awareness Basic Biobehavioral Research Behavioral Brain Brain region Clinical Conflict (Psychology)Control Groups Cost Measures Costs and Benefits Data Aggregation Decision Making Economics Exhibits Foundations Functional Magnetic Resonance Imaging Goals Heavy Drinking Human Individual Insula of Reil Interoception Intervention Intervention Studies Laboratory Study Link Literature Measures Methods Monitor Motivation Neurobiology Neurosciences Outcome Participant Pathologic Phase Prediction of Response to Therapy Prefrontal Cortex Protocols documentation Psyche structure Psychology Public Health Research Rewards Risk Marker Schedule Stress System Ventral Striatum acute stress alcohol demand alcohol measurement alcohol misuse alcohol use disorder angular gyrus behavioral study biobehavior case control cognitive control cognitive neuroscience craving design drinking executive function follow-up motivational enhancement therapy motivational intervention neural patterning neuroeconomics neuroimaging novel novel strategies phase change pre-clinical predicting response preference relating to nervous system response trait translational framework translational pipeline

项目摘要

PROJECT SUMMARY/ABSTRACT The novel field of neuroeconomics integrates concepts and methods from psychology, economics, and cognitive neuroscience to understand the neurobiological foundations of decision making, and has been increasingly applied to understanding alcohol use disorder (AUD). A novel focus in neuroeconomics is alcohol demand, or the value of alcohol as measured by cost-benefit preferences. Behaviorally, alcohol demand has been found to be elevated among individuals with higher levels of alcohol misuse and to predict treatment response. In addition, alcohol demand can also be dynamically increased via acute stress. These findings are consistent with theoretical perspectives that emphasize both stable tonic and acute phasic aspects of motivation. The overall goal of the proposed studies is to characterize the neural activity that subserves these established behavioral findings using a novel functional magnetic resonance imaging paradigm. The first aim is to examine how the brain represents the value of alcohol in individuals with AUD compared to a control group. To do so, the first study will use a between-subjects case-control design to identify differences in neural activity associated with elevations in alcohol demand in individuals with AUD (i.e., cases) versus individuals who drink regularly but do not have an AUD and are matched on key variables (i.e., controls). The second aim is to investigate the changes in neural activity associated with stress-elicited increases in the value of alcohol. To do so, a second study will use a within-subjects design, comparing demand-associated neural activity following a neutral induction to neural activity following a stress induction in individuals with AUD. The third aim is to investigate the relationship between patterns of neural activity during alcohol demand decision making and intervention response. To do so, all participants with AUD in Study #1 and Study #2 will receive Motivational Enhancement Therapy, a previously validated four-session manualized motivational interviewing intervention, and neural activity during the alcohol demand paradigm will be used to predict subsequent drinking at 1-month and 6-month follow-up. Collectively, these aims will systematically apply a novel neuroeconomic approach to diverse aspects of AUD across the translational spectrum, from basic differences in neural activity to predictors of intervention response.

项目摘要/摘要神经经济学的新领域将心理学，经济学和方法的概念和方法整合在一起认知神经科学了解决策的神经生物学基础，并且已经越来越多地应用于了解酒精使用障碍（AUD）。神经经济学的新颖重点是酒精需求或通过成本效益偏好衡量的酒精的价值。在行为上，酒精需求有发现在滥用酗酒水平的个体中，被发现升高并预测治疗回复。此外，酒精需求也可以通过急性应激动态增加。这些发现是与理论观点一致，该观点强调稳定的补品和急性阶段方面动机。拟议研究的总体目标是表征这些神经活动使用新型的功能磁共振成像范式建立的行为发现。第一个目的是与对照组相比，检查大脑如何代表AUD个体中酒精的价值。为此，第一项研究将使用受试者间的病例对照设计来识别神经活动的差异与饮酒的人相比喝酒的人的酒精需求升高有关定期但没有AUD，并且在关键变量（即控件）上匹配。第二个目标是研究与应力引起的酒精价值增加有关的神经活动的变化。做因此，第二项研究将使用受试者内部设计，以比较需求相关的神经活动 AUD患者应力诱导后，对神经活动的中性诱导。第三个目标是调查酒精需求决策过程中神经活动模式与干预响应。为此，所有具有AUD的参与者在研究＃1和研究＃2中都将获得激励性增强疗法是先前经过验证的四届手动动机访谈干预措施，酒精需求范式期间的神经活动将用于预测1个月后随后的饮酒和6个月的随访。总的来说，这些目标将系统地将新型的神经经济方法应用于从神经活动的基本差异到预测指标干预响应。