Understanding Cross-National Health Differences at Older Ages and Their Causes

了解老年人的跨国健康差异及其原因

• 批准号: 10369048
• 负责人: AXEL H BOERSCH-SUPAN
• 金额: $ 63.36万
• 依托单位: NATIONAL BUREAU OF ECONOMIC RESEARCH
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-15 至 2024-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10369048
• 关键词: Age; Aging; Archives; Biological Assay; Biological Markers; Blood; Blood specimen; Budgets; Cardiovascular Diseases; Cognition; Collection; Country; Data; Data Analyses; Data Collection; Data Reporting; Databases; Diabetes Mellitus; Economic Conditions; Economics; Europe; European; Event; Fostering; Funding; Gold; Hand Strength; Health; Health Status; Health Surveys; Health and Retirement Study; Health behavior; Healthcare; Healthcare Systems; Household; Impaired cognition; Income; Individual; Inflammation; International; Intervention; Laboratories; Legal; Life; Life Cycle Stages; Life Style; Link; Lipids; Longitudinal Studies; Measurement; Measures; Mental Health; Non-Insulin-Dependent Diabetes Mellitus; Patient Self-Report; Population; Process; Recording of previous events; Reporting; Respondent; Retirement; Sampling; Spottings; Statistical Data Interpretation; Study models; Testing; Universities; Validation; Variant; Venous; Venous blood sampling; Washington; Work; aged; base; blood-based biomarker; clinical diagnosis; data harmonization; health care quality; health difference; health economics; instrumental activity of daily living; response; social; socioeconomics; user-friendly

OTHER PROJECT INFORMATION – Project Summary/Abstract Understanding Cross-National Health Differences at Older Ages and Their Causes This project aims to foster understanding of cross-national differences in health and their causes, especially evaluating differences in health care systems, coverage and quality, health behaviors, life styles, income and wealth distributions and historical life circumstances. Understanding differences and causes requires comparable measurements of health which do not suffer from cross-national differences in data collection and reporting styles. In this respect, analyses of blood samples are a gold standard of objective health measurement. The project will extend earlier blood-based health comparisons between the US (based on the Health and Retirement Study, HRS) and the UK (based on the English Longitudinal Study of Ageing, ELSA) to Continental Europe (based on the Survey of Health, Aging and Retirement in Europe, SHARE). SHARE is a large population-representative panel study modelled after the HRS and ELSA. Health variables strictly harmonized across the three studies include self-reported health, ADLs and IADLs, physical measurements such as grip strength, peak flow and chair stand, and a large battery of tests for cognition and mental health. SHARE has obtained very rich data on health care systems and life styles, on economic, work and social circumstances over the life course, and individual histories of health behaviors and health care interventions. SHARE has also collected dried blood spot samples (DBSS) from about 27.000 respondents aged 50 and older in 13 Continental European countries. HRS has also collected DBSS in recent waves. While DBSS are not perfect substitutes for the venous blood (VB) samples obtained by ELSA and currently by HRS, much progress has recently been made in understanding how values obtained from DBSS correspond to VB values. We have performed extensive validations which show a tight alignment between DBSS and VB values after correcting for systematic factors that occur during the laboratory and field processes. The project has four specific aims: 1. Capitalize upon the expertise of the laboratory at the University of Washington by having the full set of DBSS collected in SHARE wave 6 assayed for the lipid panel and type-2 diabetes mellitus (T2DM) biomarkers relevant to general health and cognitive decline. 2. Link the laboratory analyses with the SHARE functional and subjective health, demographic, social, and economic data, create a user-friendly database and archive it. 3. Harmonize the data obtained from the assays of SHARE DBS, ELSA VB and HRS DBS and VB. 4. Use these data to perform statistical analyses on the relationships between cross-national differences in health, economic, work and social circumstances, health behaviors and health care interventions.

其他项目信息 - 项目摘要/摘要 了解老年及其原因的跨国健康差异 该项目旨在促进对健康及其原因的跨国差异的理解，尤其是 评估卫生保健系统，覆盖范围和质量，健康行为，生活方式，收入和收入的差异 财富分布和历史生活环境。了解差异和原因需要 可比较的健康测量结果，这些测量不遭受数据收集的跨国差异和 报告样式。在这方面，血液样本的分析是客观健康测量的黄金标准。 该项目将延长美国之间早期基于血液的健康比较（根据健康和 退休研究，HRS）和英国（基于英国衰老纵向研究，ELSA）到大陆 欧洲（根据欧洲的卫生，衰老和退休调查）。分享很大 以HRS和ELSA为模型的人口代表性小组研究。健康变量严格协调 在这三项研究中，包括自我报告的健康，ADL和IADL，身体测量等 强度，峰值流和椅子支架，以及大量的认知和心理健康测试。分享有 获得了有关医疗保健系统和生活方式，经济，工作和社会环境的非常丰富的数据 生活过程以及健康行为和医疗保健干预措施的个人历史。 共享还收集了大约27.000岁的50岁及以上受访者的干血点样本（DBS） 在13个欧洲大陆国家。 HRS还在最近的波浪中收集了DBS。虽然DBS并不完美 Elsa和目前由HRS获得的静脉血（VB）样品的替代品，很多进展已有 最近制作了从DBSS获得的值对应于VB值的值。我们有 进行了广泛的验证，这些验证显示DBS和VB值之间的紧密对齐 实验室和现场过程中发生的系统因素。 该项目具有四个具体目标： 1。利用华盛顿大学实验室的专业知识。 分配给脂质面板和2型糖尿病（T2DM）的共享Wave 6中收集的DBSS 与一般健康和认知能力下降有关的生物标志物。 2。将实验室分析与份额的功能和主观健康，人口统计，社会和 经济数据，创建一个用户友好的数据库并存档。 3。从共享DB，ELSA VB和HRS DBS和VB的Assas获得的数据进行协调。 4。使用这些数据对跨国差异之间的关系进行统计分析 健康，经济，工作和社会环境，健康行为和卫生保健干预措施。