Bio-medical and socio-economic precursors of cognitive decline in SHARE

SHARE认知能力下降的生物医学和社会经济先兆

• 批准号: 9925769
• 负责人: AXEL H BOERSCH-SUPAN
• 金额: $ 129.33万
• 依托单位: MAX PLANCK INST/SOCIAL LAW/SOCIAL POLICY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-30 至 2022-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9925769
• 关键词: Address; Affect; Age; Aging; Alzheimer' s Disease; Archives; Biological; Biological Assay; Biological Markers; Blood; Brain-Derived Neurotrophic Factor; Characteristics; Cholesterol; Cognition; Cognitive; Collection; Country; Data; Data Collection; Databases; Dementia; Denmark; Diagnosis; Early Intervention; Economic Conditions; Economic Factors; Education; Elderly; Environment; Europe; European; France; Funding; Germany; Glycosylated hemoglobin A; HDL-triglyceride; Hand Strength; Health; Health Surveys; Health and Retirement Study; Impaired cognition; International; Israel; Italy; Laboratories; Life; Life Cycle Stages; Lipids; Long-Term Care; Longitudinal Studies; Measurement; Measures; Mediating; Mental Health; Modeling; Non-Insulin-Dependent Diabetes Mellitus; Participant; Pathway interactions; Patient Self-Report; Poland; Policies; Population; Prevalence; Prevention Measures; Preventive; Process; Proteins; Protocols documentation; Research Priority; Respondent; Retirement; Risk Factors; Running; Sampling; Sampling Studies; Social Environment; Spottings; Surveys; Symptoms; Testing; Universities; Variant; Vascular Dementia; Washington; World War II; base; blood lipid; care systems; cognitive testing; cytokine; design; health economics; instrument; instrumental activity of daily living; life history; mild cognitive impairment; mortality; post gamma-globulins; response; social; socioeconomics; user-friendly

PROJECT ABSTRACT The general aim of this project is to exploit the international variation of health and life circumstances in Continental Europe to identify which interactions of bio-medical and socio-economic conditions over the life course affect cognition in later life. The project will leverage the EU-funding of the Survey of Health, Aging and Retirement in Europe (SHARE) and addresses a number of key research priorities for NIA: The study of older adults in a diverse array of countries will provide valuable information on cognitive status and relate it to the socio-economic and social environment of the elderly as well as biomarkers that may serve as instruments to target early prevention measures. It will enhance our understanding how the vastly differing social, health and long-term care systems affect mental health and resulting mortality of the aging populations. This holds especially for the life circumstances in Europe since World War II which are likely to have influenced cognitive decline now at older ages. Moreover, the large variation in key policy variables, e.g. retirement age, identifies pathways from early retirement through inactivity and loss of social contacts to lower cognition, mediated by education, working environment and other socio-economic factors over the life-course. SHARE is a large population-representative panel study closely modeled after the US Health and Retirement Study (HRS) in currently 27 Continental European countries plus Israel. Strictly harmonized health variables for the about 80,000 respondents include self-reported health, functional health, physical measurements such as grip strength, peak flow and chair stand, and a large battery of tests for cognition and mental health. Moreover, SHARE has collected dried blood spot samples from some 27,000 respondents. The project will fill two strategic gaps in the harmonization between HRS and SHARE. It will 1. Administer an in-depth measurement of cognition according to the Harmonized Cognitive Assessment Protocol (HCAP) that has been developed for the HRS-style aging surveys supported by NIA. 2. Analyze the blood collected by SHARE for blood lipids and other biomarkers that have been found to correlate with cognitive decline, vascular dementia and Alzheimer's disease. Using these data, the project will estimate prevalence rates of mild and severe cognitive impairment in the SHARE countries; compare these with HRS and other participants in the HCAP studies; and exploit the international variation of the SHARE plus SHARE-HCAP data in order to identify which interactions of biomedical and socioeconomic conditions over the life course affect cognition later in life. This project is synchronized with the long-run agenda of the SHARE panel which has collected blood in wave 6, is currently administering a life-history module in Wave 7 and will feature an extended cognition module in Wave 8. Funding is restricted to the additional data collection efforts for SHARE-HCAP and the analyses of blood taken in wave 6 and in the SHARE-HCAP substudy for markers associated with cognitive decline.

项目摘要 该项目的总体目的是利用健康和生活环境的国际差异 欧洲大陆以确定生命中生物医学和社会经济状况的哪些相互作用 课程影响后来的认知。该项目将利用欧盟的卫生，老龄化调查和 在欧洲退休（共享），并针对NIA的许多关键研究重点：对年长的研究 各种各样的国家的成年人将提供有关认知状况的有价值的信息，并将其与 老年人的社会经济和社会环境以及生物标志物，可以作为工具 针对早期预防措施。它将增强我们的理解，社会，健康以及 长期护理系统会影响心理健康，并导致老龄化人群的死亡率。这是 特别是对于自第二次世界大战以来欧洲的生活环境，可能会影响认知 现在年龄较大的年龄下降。此外，关键策略变量的较大变化，例如退休年龄，确定 从早期退休到社会接触丧失到较低认知的途径，由 在生命过程中的教育，工作环境和其他社会经济因素。 共享是一项大量人口代表性的小组研究，以美国的健康和退休为基础 目前27个欧洲大陆国家以及以色列的研究（HRS）。严格协调的健康变量 大约80,000名受访者包括自我报告的健康，功能健康，身体测量 作为抓地力，峰值流动和椅子支架，以及大量的认知和心理健康测试。 此外，Share已收集了约27,000名受访者的血点样本。 该项目将填补人力资源和共享之间的协调方面的两个战略差距。会 1。根据统一的认知评估对认知进行深入测量 为NIA支持的HRS型老化调查开发的协议（HCAP）。 2。分析份额收集的血液脂质和其他发现的生物标志物 与认知能力下降，血管痴呆和阿尔茨海默氏病相关。 使用这些数据，该项目将估计轻度和严重认知障碍的患病率 共享国家；将它们与HCAP研究中的HR和其他参与者进行比较；并利用 股份的国际差异以及共享hcap数据，以确定哪些相互作用 生命过程中的生物医学和社会经济状况会影响生活后期的认知。 该项目与共享面板的长期议程同步，该议程已在波浪中收集了血液 6，目前正在Wave 7中管理一个生活史模块，并将具有扩展的认知模块 第8浪。资金仅限于共享HCAP的其他数据收集工作和分析 在第6波中获得的血液以及与认知能力下降有关的标志物的共享hcap蛋白。