Bio-medical and socio-economic precursors of cognitive decline in SHARE

SHARE认知能力下降的生物医学和社会经济先兆

• 批准号: 9925769
• 负责人: AXEL H BOERSCH-SUPAN
• 金额: $ 129.33万
• 依托单位: MAX PLANCK INST/SOCIAL LAW/SOCIAL POLICY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-30 至 2022-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9925769
• 关键词: Address; Affect; Age; Aging; Alzheimer' s Disease; Archives; Biological; Biological Assay; Biological Markers; Blood; Brain-Derived Neurotrophic Factor; Characteristics; Cholesterol; Cognition; Cognitive; Collection; Country; Data; Data Collection; Databases; Dementia; Denmark; Diagnosis; Early Intervention; Economic Conditions; Economic Factors; Education; Elderly; Environment; Europe; European; France; Funding; Germany; Glycosylated hemoglobin A; HDL-triglyceride; Hand Strength; Health; Health Surveys; Health and Retirement Study; Impaired cognition; International; Israel; Italy; Laboratories; Life; Life Cycle Stages; Lipids; Long-Term Care; Longitudinal Studies; Measurement; Measures; Mediating; Mental Health; Modeling; Non-Insulin-Dependent Diabetes Mellitus; Participant; Pathway interactions; Patient Self-Report; Poland; Policies; Population; Prevalence; Prevention Measures; Preventive; Process; Proteins; Protocols documentation; Research Priority; Respondent; Retirement; Risk Factors; Running; Sampling; Sampling Studies; Social Environment; Spottings; Surveys; Symptoms; Testing; Universities; Variant; Vascular Dementia; Washington; World War II; base; blood lipid; care systems; cognitive testing; cytokine; design; health economics; instrument; instrumental activity of daily living; life history; mild cognitive impairment; mortality; post gamma-globulins; response; social; socioeconomics; user-friendly

PROJECT ABSTRACT The general aim of this project is to exploit the international variation of health and life circumstances in Continental Europe to identify which interactions of bio-medical and socio-economic conditions over the life course affect cognition in later life. The project will leverage the EU-funding of the Survey of Health, Aging and Retirement in Europe (SHARE) and addresses a number of key research priorities for NIA: The study of older adults in a diverse array of countries will provide valuable information on cognitive status and relate it to the socio-economic and social environment of the elderly as well as biomarkers that may serve as instruments to target early prevention measures. It will enhance our understanding how the vastly differing social, health and long-term care systems affect mental health and resulting mortality of the aging populations. This holds especially for the life circumstances in Europe since World War II which are likely to have influenced cognitive decline now at older ages. Moreover, the large variation in key policy variables, e.g. retirement age, identifies pathways from early retirement through inactivity and loss of social contacts to lower cognition, mediated by education, working environment and other socio-economic factors over the life-course. SHARE is a large population-representative panel study closely modeled after the US Health and Retirement Study (HRS) in currently 27 Continental European countries plus Israel. Strictly harmonized health variables for the about 80,000 respondents include self-reported health, functional health, physical measurements such as grip strength, peak flow and chair stand, and a large battery of tests for cognition and mental health. Moreover, SHARE has collected dried blood spot samples from some 27,000 respondents. The project will fill two strategic gaps in the harmonization between HRS and SHARE. It will 1. Administer an in-depth measurement of cognition according to the Harmonized Cognitive Assessment Protocol (HCAP) that has been developed for the HRS-style aging surveys supported by NIA. 2. Analyze the blood collected by SHARE for blood lipids and other biomarkers that have been found to correlate with cognitive decline, vascular dementia and Alzheimer's disease. Using these data, the project will estimate prevalence rates of mild and severe cognitive impairment in the SHARE countries; compare these with HRS and other participants in the HCAP studies; and exploit the international variation of the SHARE plus SHARE-HCAP data in order to identify which interactions of biomedical and socioeconomic conditions over the life course affect cognition later in life. This project is synchronized with the long-run agenda of the SHARE panel which has collected blood in wave 6, is currently administering a life-history module in Wave 7 and will feature an extended cognition module in Wave 8. Funding is restricted to the additional data collection efforts for SHARE-HCAP and the analyses of blood taken in wave 6 and in the SHARE-HCAP substudy for markers associated with cognitive decline.

项目摘要 该项目的总体目标是利用健康和生活环境的国际差异 欧洲大陆确定生命中生物医学和社会经济条件的相互作用 当然会影响以后的生活认知。该项目将利用欧盟对健康、老龄化和健康调查的资助 欧洲退休 (SHARE) 并解决了 NIA 的一些关键研究重点：老年人的研究 不同国家的成年人将提供有关认知状态的宝贵信息，并将其与 老年人的社会经济和社会环境以及可作为工具的生物标志物 采取早期预防措施。它将增强我们对截然不同的社会、健康和 长期护理系统影响老年人口的心理健康和由此导致的死亡率。这成立 尤其是二战以来欧洲的生活环境可能影响了认知 现在年龄较大时会下降。此外，关键政策变量的巨大变化，例如退休年龄，确定 从提前退休到不活动和失去社会联系到认知能力下降的途径，由以​​下因素介导 生命历程中的教育、工作环境和其他社会经济因素。 SHARE 是一项以美国健康和退休计划为蓝本的大型人群代表性小组研究 目前在 27 个欧洲大陆国家以及以色列开展研究 (HRS)。严格协调的健康变量 大约 80,000 名受访者包括自我报告的健康状况、功能健康、身体测量等 例如握力、峰值流量和椅子站立，以及大量认知和心理健康测试。 此外，SHARE 还从约 27,000 名受访者那里收集了干血斑样本。 该项目将填补 HRS 和 SHARE 协调方面的两个战略空白。它会 1. 根据协调认知评估对认知进行深入测量 为 NIA 支持的 HRS 式老龄化调查开发的协议 (HCAP)。 2. 分析 SHARE 采集的血液中的血脂和其他已发现的生物标志物 与认知能力下降、血管性痴呆和阿尔茨海默病相关。 利用这些数据，该项目将估计轻度和重度认知障碍的患病率 分享国家；将这些与 HRS 和 HCAP 研究中的其他参与者进行比较；并利用 SHARE 和 SHARE-HCAP 数据的国际差异，以确定哪些相互作用 生命历程中的生物医学和社会经济条件会影响以后的认知。 这个项目与SHARE小组的长期议程同步，该小组已在浪潮中收集了血液 6，目前正在管理 Wave 7 中的生活史模块，并将在 第 8 波。资金仅限于 SHARE-HCAP 的额外数据收集工作和分析 在第 6 波和 SHARE-HCAP 子研究中采集的血液，用于检测与认知能力下降相关的标记物。