ACTG 362:LONG-TERM ASSESSMENT FOR METABOLIC, CARDIOVASCULAR AND NEUROLOGIC COMP

ACTG 362：代谢、心血管和神经系统的长期评估

• 批准号: 7604177
• 负责人: ROY M. GULICK
• 金额: $ 0.13万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604177
• 关键词: AIDS clinical trial group; CD4 Lymphocyte Count; Cardiovascular system; Cells; Clinical; Computer Retrieval of Information on Scientific Projects Database; Fasting; Funding; Glucose; Grant; Hypertension; Immunologic Markers; Impaired cognition; Incidence; Institution; Insulin Resistance; Measures; Metabolic; Metabolic syndrome; Natural History; Neurologic; Neurologic Examination; Neurology; Neuropsychology; Opportunistic Infections; Peripheral Nervous System Diseases; Prevalence; Research; Research Personnel; Resources; Screening procedure; Source; Time; United States National Institutes of Health; antiretroviral therapy; reconstitution

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. AIDS Clinical Trials Group Study 362 is a multicenter, long-term natural history study to assess metabolic, cardiovascular, and neurologic complications in subjects with a past CD4 count <50 cells/mm3 who increased to >100 cells/mm3 on antiretroviral therapy. The primary objectives for ACTG 362 are: Cardiovascular/Metabolic: to examine the incidence and prevalence, and changes over time of hypertension, insulin resistance, abnormal fasting glucose, and the metabolic syndrome in subjects on long-term antiretroviral therapy (ART). Opportunistic Infections: to examine the incidence of opportunistic infections, describe their clinical presentations, and correlate their incidence and clinical presentations with markers of immune reconstitution and virological control. Neurology: to examine the incidence and prevalence, and changes in these measures over time, of cognitive impairment and peripheral neuropathy as ascertained by a screening neuropsychologic and neurologic examination.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 艾滋病临床试验小组研究 362 是一项多中心、长期自然史研究，旨在评估过去 CD4 计数 <50 个细胞/mm3 且接受抗逆转录病毒治疗后增加至 >100 个细胞/mm3 的受试者的代谢、心血管和神经系统并发症。 ACTG 362 的主要目标是： 心血管/代谢：检查长期抗逆转录病毒治疗 (ART) 受试者中高血压、胰岛素抵抗、异常空腹血糖和代谢综合征的发病率和患病率以及随时间的变化。 机会性感染：检查机会性感染的发生率，描述其临床表现，并将其发生率和临床表现与免疫重建和病毒学控制标志物相关联。 神经病学：通过筛查神经心理学和神经病学检查确定认知障碍和周围神经病的发生率和患病率以及这些指标随时间的变化。