HEAL Diversity Supplement: Great Lakes Nodes Clinical Trials Network

HEAL 多样性补充：五大湖节点临床试验网络

• 批准号: 10354615
• 负责人: Niranjan Subhash Karnik
• 金额: $ 7.1万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-06-15 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10354615
• 关键词: Abstinence; Academia; Address; Adherence; Affect; Affective; Applications Grants; Area; Artificial Intelligence; Attitude; Autonomic nervous system; Biological Markers; Brain; California; Cellular Phone; Chest; Chronic; Clinical Treatment; Clinical Trials Network; Complex; Data; Development; Devices; Disease; Disease model; Drug Addiction; Drug abuse; Drug usage; Ecological momentary assessment; Faculty; Frequencies; Future; Goals; Growth; Health; Health Sciences; Individual; Individual National Research Service Award; Informatics; Intervention; Interview; Knowledge; Location; Longitudinal Studies; Machine Learning; Manufacturer Name; Measures; Mentors; Mentorship; Methods; Monitor; Motivation; National Institute of Drug Abuse; Neurobiology; Noise; Overdose; Participant; Patient Self-Report; Pharmaceutical Preparations; Physiological; Physiology; Pilot Projects; Positioning Attribute; Preparation; Procedures; Psychophysiology; Relapse; Research; Research Activity; Research Personnel; Research Training; Risk; Role; Science; Scientist; Signal Transduction; Societies; Stress; Structure; Substance Use Disorder; System; Technical Expertise; Time; Training; Universities; Validity and Reliability; Veronica; Withdrawal; Work; Wrist; Writing; adaptive intervention; addiction; base; career; digital; digital mental health; digital treatment; experience; heart rate variability; implementation science; indexing; mHealth; member; mid-career faculty; mobile computing; multidisciplinary; negative affect; new technology; novel; opioid epidemic; opioid use disorder; parent grant; pre-doctoral; professor; programs; psychologic; response; sensor; statistics; stress reactivity; substance misuse; substance use; wearable device; wearable sensor technology

Project Summary/Abstract We assess the feasibility of mobile technologies to study the psychophysiological underpinnings of affect in Opioid Use Disorder (OUD). In this feasibility pilot study, we will evaluate participants’ adherence to the procedures of a longitudinal study, including: 1. wearing wearable sensors for the duration of the study, 2. completing research activities involving prompted and self-initiated self-reports on momentary experiences of stress and negative affect. We will also examine the validity and reliability of the physiological data captured with two wearable sensors from two different brands and that are placed in different body locations. It is important to assess the reliability of data from two devices simultaneously to examine issues that may hinder a study’s viability, like data noise, signal problems, or data loss, etc. Lastly, we will utilize this data to investigate the role of autonomic function as a valid physiological marker of stress and negative affect in OUD. This has relevant implications in the understanding and development of digital treatments, as stress and negative affect are major contributors of relapse. This pilot work will contribute to the aim 2 of the parent grant by using digital and computational health cores to advance research in mHealth, artificial intelligence, and machine learning. In addition, the work supported under this supplement will serve as a building block to successfully create and submit an F31 grant proposal, a research that will be carried out following the diversity supplement period. This supplement will support the intensive training and invaluable practical experience that will advance the career of the trainee, Veronica Ramirez. This is in alignment with aim 6 of the parent grant to “expand the pipeline for early investigators” and create programs that support “addiction and substance misuse research, training, and mentorship”. Aligned with this, our research can ultimately help current efforts to address the opioid epidemic to ameliorate its detrimental effects on society.

项目概要/摘要 我们评估移动技术研究心理生理基础的可行性 在这项可行性试点研究中，我们将评估阿片类药物使用障碍 (OUD) 的影响。 参与者的佩戴遵守纵向研究的程序，包括： 1. 可穿戴 2. 在研究期间完成研究活动，包括提示和 我们也会主动自我报告暂时的压力和负面情绪经历。 检查两个可穿戴传感器捕获的生理数据的有效性和可靠性 来自两个不同的品牌，并且放置在不同的身体位置。 同时评估来自两个设备的数据的可靠性，以检查可能阻碍的问题 研究的可行性，例如数据噪声、信号问题或数据丢失等。最后，我们将利用此 研究自主神经功能作为压力和压力的有效生理标志物的作用的数据 这对 OUD 的理解和发展具有相关影响。 数字治疗，因为压力和负面影响是复发的主要原因。 将通过使用数字和计算健康核心来为家长补助金的目标 2 做出贡献 此外，还有移动健康、人工智能和机器学习方面的研究。 本补充文件的支持将作为成功创建和提交的基石 F31 拨款提案，一项将在多样性补充之后进行的研究 该补充将支持强化培训和宝贵的实践经验。 这将促进实习生 Veronica Ramirez 的职业生涯 这与目标 6 一致。 家长拨款“扩大早期研究人员的渠道”并创建项目 支持“成瘾和药物滥用研究、培训和指导”， 我们的研究最终可以帮助当前解决阿片类药物流行病的努力，以改善其 对社会的影响。