Great Lakes Node of the Drug Abuse Clinical Trials Network

药物滥用临床试验网络五大湖节点

• 批准号: 10545971
• 负责人: Niranjan Subhash Karnik
• 金额: $ 6.14万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-06-15 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10545971
• 关键词: Academic Medical Centers; Adolescent; African American population; Aging; Area; Artificial Intelligence; Asian; Buprenorphine; Caring; Cessation of life; Chicago; Cities; Clinical Trials; Clinical Trials Network; Collaborations; Communities; County; Data Analytics; Distance Education; Drug abuse; Electronic Health Record; Emergency department visit; Epidemic; Federal Government; Gender Identity; Geography; Health; Health system; Heroin; Home; Homelessness; Hospitals; Illinois; Indiana; Individual; Intervention; Latino; Learning; Life Cycle Stages; Los Angeles; Mentorship; Methods; Midwestern United States; Minority; Modeling; Morbidity - disease rate; National Institute of Drug Abuse; Native Americans; Natural Language Processing; New York; Opioid; Opioid Analgesics; Pacific Islander; Pathway interactions; Population; Prevention strategy; Professional Education; Professional Practice; Protocols documentation; Public Health; Refugees; Research; Research Methodology; Research Personnel; Research Training; Rest; Rural; Sex Orientation; Side; System; Testing; Training; Training Support; United States National Institutes of Health; Universities; Veterans; Vulnerable Populations; Wisconsin; Work; addiction; adolescent health; base; collaborative care; cooking; digital; eHealth; ethnic diversity; experience; health disparity; interest; mHealth; medical schools; metropolitan; mobile computing; mortality; novel; opioid misuse; opioid overdose; opioid treatment program; overdose death; population health; programs; racial and ethnic; racial diversity; rural area; screening; sexual identity; socioeconomics; substance misuse; suburb; success; telehealth; urban area; vulnerable community; waiver; young adult

Project Summary/Abstract In alignment with RFA-DA-19-008, this application seeks to establish the Great Lakes Node (GLN) of the NIDA-supported Drug Abuse Clinical Trials Network (CTN). This node will draw on an experienced set of investigators who have active collaborations and represent all of the major academic medical centers in the Greater Chicago and Wisconsin areas. The node will serve as a vital Midwestern hub for the CTN and will expand on the success of the CTN approach. In addition, the GLN will bring substantial experience in adolescent/young adult research, seniors/aging research, digital & mobile technologies, opioid misuse, collaborative care/population health, telehealth, and electronic health record and systems-driven interventions and research methodologies. The GLN will support engagement with CTN protocols and also add the following: Aim 1: GLN will identify and recommend substance misuse research and intervention protocols focused on systems-based practice using hospital-based screening, collaborative care, and population approaches. Aim 2: We will establish a digital and computation health core that will leverage our expertise in these domains and serve as a conduit for studies in mHealth, eHealth, artificial intelligence, natural language processing, and telehealth interventions. Aim 3: Our node will bring substantial expertise with youth/adolescent health and seniors/aging that will enable us to recommend studies to the CTN that examine the genesis of substance misuse and the potential for prevention strategies to mitigate these life-course pathways. Aim 4: In alignment with our team’s expertise, we plan to support work on substance and opioid misuse that focuses on health disparities including socioeconomic, geographic, sexual orientation, and gender identity. Aim 5: Leveraging our experience in professional education and practice-based learning, our node will rigorously test the impact of professional education on opioid and substance treatment. We have built on the ECHO model to develop methods to conduct high-quality distance education and supported training that are currently being trialed in Illinois with plans to expand these programs nationally. Aim 6: GLN will expand the pipeline of early investigators interested in substance misuse research. We will align this part of our program with our very successful CTSA-supported programs and build specific subprogramming that supports addiction and substance misuse research, training, and mentorship.

项目概要/摘要 根据 RFA-DA-19-008，本申请旨在建立五大湖节点 (GLN) NIDA 支持的药物滥用临床试验网络 (CTN) 该节点将利用一组经验丰富的人员。 积极合作并代表所有主要学术医疗中心的研究人员 大芝加哥和威斯康星州地区将成为 CTN 的重要中西部枢纽。 扩大 CTN 方法的成功此外，GLN 将带来以下方面的丰富经验。 青少年/年轻人研究、老年人/老龄化研究、数字和移动技术、阿片类药物滥用、 协作护理/人口健康、远程医疗、电子健康记录和系统驱动的干预措施 和研究方法。 GLN 将支持与 CTN 协议的互动，并添加以下内容： 目标 1：GLN 将确定并推荐药物滥用研究和干预方案，重点关注 使用基于医院的筛查、协作护理和人口方法的基于系统的实践。 目标 2：我们将建立一个数字和计算健康核心，利用我们在这些领域的专业知识 并作为移动医疗、电子医疗、人工智能、自然语言处理和 远程医疗干预。 目标 3：我们的节点将带来青年/青少年健康和老年人/老龄化方面的丰富专业知识，这将使 我们向 CTN 推荐研究物质滥用的根源以及滥用药物的可能性 缓解这些生命历程路径的预防策略。 目标 4：根据我们团队的专业知识，我们计划支持物质和阿片类药物滥用方面的工作， 重点关注健康差异，包括社会经济、地理、性取向和性别认同。 目标 5：利用我们在专业教育和基于实践的学习方面的经验，我们的节点将 我们严格测试专业教育对阿片类药物和药物治疗的影响。 ECHO 模型开发进行高质量远程教育和支持培训的方法 目前正在伊利诺伊州进行试验，并计划将这些计划扩展到全国。 目标 6：GLN 将扩大对药物滥用研究感兴趣的早期研究者的渠道。 使我们计划的这一部分与我们非常成功的 CTSA 支持的计划保持一致，并建立具体的 支持成瘾和药物滥用研究、培训和指导的子计划。