Analytical capacity building for the study of tobacco carcinogen exposures in India

印度烟草致癌物暴露研究的分析能力建设

• 批准号: 9371941
• 负责人: Pankaj Chaturvedi
• 金额: $ 28.6万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-22 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9371941
• 关键词: Address; Advocacy; Alcohol consumption; Area; Aromatic Polycyclic Hydrocarbons; Biochemical; Biological Markers; Butanones; Cancer Etiology; Carcinogen exposure; Carcinogens; Case-Control Studies; Cessation of life; Characteristics; Chemicals; Clinical; Clinical Research; Collaborations; Communities; Cotinine; Custom; Data; Development; Education; Ensure; Epidemiology; Etiology; Formulation; Goals; Head and Neck Cancer; Health; Hospitals; India; Institutes; Institution; Knowledge; Laboratories; Limes; Link; Malignant Neoplasms; Malignant neoplasm of esophagus; Malignant neoplasm of pancreas; Measures; Morbidity - disease rate; N' -nitrosonornicotine; Nicotine; Nitrates; Nitrites; Nitrosamines; Oral; Participant; Perception; Play; Population; Positioning Attribute; Preparation; Procedures; Public Health; Research; Research Personnel; Research Training; Resources; Role; Scientist; Smokeless Tobacco; Tobacco; Tobacco use; Tobacco-Associated Carcinogen; Training; Training Activity; Variant; Vision; Work; World Health Organization; base; cancer risk; carcinogenicity; data resource; head and neck cancer patient; insight; malignant mouth neoplasm; mortality; multidisciplinary; novel; programs; public health research; repository; smoking prevalence; snuff; snus; tobacco carcinogenesis; uptake; urinary; web portal; webinar

ABSTRACT Cancer risks associated with the use of smokeless tobacco (SLT) products worldwide vary drastically. There is a critical need to better understand SLT carcinogenesis, and which chemical constituents and/or product characteristics drive the risk of cancer development in SLT users. India has a unique tobacco burden profile and represents both an area of critical need and unique setting for such studies. Nearly one third of the population in India is using various forms of SLT, exceeding the prevalence of smoking. This is accompanied by high rates of oral and head and neck cancer (OHNC), which is strongly associated with SLT use and is a leading cause of cancer-related death in India. The goal of our proposal is to investigate the relationship between carcinogen content in SLT products and relevant exposures as well as OHNC risk in users of these products, while concurrently building capacity for a sustainable tobacco carcinogenesis research program in India. We will focus on the tobacco-specific nitrosamines N'-nitrosonornicotine (NNN) and 4- (methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Our first aim will be to determine the variation of NNN and NNK in SLT products currently available in Mumbai including a wide range of both manufactured and cottage-made products. Our second aim will be to examine the relationship between NNN and NNK levels in SLT products and the levels of corresponding biomarkers in users of these products. In this aim, we will assess biomarkers of exposure in 300 users of SLT products with differing NNN and NNK content, as established in Aim 1. In our third aim, we will compare levels of urinary NNN and NNK biomarkers between SLT users with and without OHNC. Together, these studies we will generate important insights into the role of NNN and NNK in SLT carcinogenesis in India. While substantial work has been carried out by the Indian public health research and advocacy community to generate valuable knowledge on SLT use, perceptions, and epidemiology, biomarker-based studies of tobacco carcinogen exposure and cancer risk have never been conducted in India. Our research team is uniquely positioned to initiate this research, as it will leverage our collaborative partnership with clinicians and scientists at Tata Memorial Hospital and its affiliated Advanced Center for Training, Research and Education in Cancer in Mumbai. In addition to generating novel scientific data, this study will incorporate capacity building activities that are closely linked to the Specific Aims and include the development of analytical laboratory capacity, training of young investigators from Mumbai in tobacco research procedures, and establishment of tobacco product and biospecimen repositories for future research.

抽象的 与全球使用无烟烟草（SLT）产品使用相关的癌症风险差异很大。有 更好地了解SLT癌变以及哪些化学成分和/或产品的迫切需要 特征推动了SLT使用者患癌症发展的风险。印度有独特的烟草负担。 并代表了此类研究的关键需求和独特的环境。近三分之一 印度的人口正在使用各种形式的SLT，超过了吸烟的流行。这是伴随的 通过高口服和头颈癌（OHNC）的高率，这与SLT的使用密切相关，是一个 印度与癌症相关死亡的主要原因。我们建议的目的是调查关系 在SLT产品中的致癌物含量与相关的暴露以及用户中的OHNC风险之间 产品，同时为可持续烟草致癌研究计划增强能力 印度。我们将专注于烟草特异性的亚硝胺N'-硝基氨酸（NNN）和4-- （甲基硝基氨基氨基）-1-（3-吡啶基）-1-丁酮（NNK）。我们的第一个目的是确定NNN的变化 当前在孟买提供的SLT产品中的NNK，包括各种制造和 小屋制造的产品。我们的第二个目标是检查NNN和NNK级别之间的关系 SLT产品和这些产品用户中相应的生物标志物的水平。在此目标中，我们将评估 在300种具有不同NNN和NNK含量不同的SLT产品中接触的生物标志物，如 目标1。在我们的第三个目标中，我们将比较SLT用户之间的尿NNN和NNK生物标志物的水平 并且没有OHNC。总之，这些研究将对NNN和NNK的作用产生重要的见解 在印度的SLT致癌作用中。虽然印度公共卫生已经进行了大量工作 研究和倡导社区，以产生有关SLT使用，看法和的宝贵知识 流行病学，基于生物标记的烟草致癌和癌症风险的研究从未有过 在印度进行。我们的研究团队独特地启动这项研究，因为它将利用我们的 与塔塔纪念医院的临床医生和科学家的合作伙伴关系及其附属高级 孟买癌症培训，研究和教育中心。除了产生新颖的科学 数据，本研究将结合与特定目的密切相关的能力建设活动 包括开发分析实验室能力，孟买的年轻研究人员的培训 烟草研究程序，并建立未来的烟草产品和生物循环库 研究。