2018 Barriers of the CNS Gordon Research Conference and Gordon Research Seminar

2018 CNS戈登研究会议和戈登研究研讨会的障碍

• 批准号: 9542556
• 负责人: William Elmquist
• 金额: $ 2.39万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-03-01 至 2019-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9542556
• 关键词: Address; Alzheimer' s Disease; Bioinformatics; Biomedical Engineering; Blood; Blood - brain barrier anatomy; Blood Circulation; Brain; Brain Neoplasms; Central Nervous System Diseases; Clinical; Collaborations; Communities; Complex; Computer Simulation; Development; Diagnosis; Diagnostic; Disease; Drug Delivery Systems; Environment; Epithelial; Faculty; Feedback; Fostering; Funding; Goals; Growth and Development function; Health; Homeostasis; Immune system; International; Knowledge; Lead; Maintenance; Measures; Mentors; Mentorship; Metastatic malignant neoplasm to brain; Methods; Molecular; Neuraxis; New Hampshire; Participant; Pharmaceutical Preparations; Postdoctoral Fellow; Public Health; Regulation; Request for Applications; Request for Proposals; Research; Research Methodology; Research Personnel; Role; Science; Scientist; Senior Scientist; Structure; Students; Technology; Therapeutic; career; college; data mining; fluid flow; genetic signature; improved; innovation; insight; interest; intravital microscopy; mathematical model; meetings; multidisciplinary; nervous system disorder; neurotoxic; new technology; novel; novel strategies; palliative; peer; posters; prevent; symposium; transcriptome; tumor growth

Project Summary / Abstract This proposal requests support for partial funding of the 2018 “Barriers of the Central Nervous System (CNS)” GRC and GRS that will be held at Colby Sawyer College, New Hampshire, on June 16-17, 2018 (GRS) and June 17-22, 2018 (GRC). The overall goal of this international conference is to improve understanding of the highly complex cellular and molecular mechanisms regulating the function of the endothelial (e.g. blood-brain barrier (BBB)) and epithelial (e.g. blood-CSF barrier (BCSFB)) brain barriers in development, maintenance and disease. The 2018 meetings will achieve this goal by covering major aspects of CNS barrier sciences and by making a special effort to include novel research methodology such as advanced intravital microscopy, mathematical modelling, bioinformatics and bioengineering; which will allow participants to obtain insights in brain barrier function from novel angles. This interdisciplinary knowledge exchange will be fostered by invited talks and daily poster presentations. The meeting will start with a keynote session on the role of the brain barriers in regulating CNS immune privilege and conclude with a trendsetting keynote session on chip technology for bioengineering the brain barriers. An additional 7 sessions will address: i) the role of brain barriers in CNS fluid flow, ii) the brain barriers in development and homeostasis, iii) brain barriers bioinformatics including introduction of a novel data-mining platform, the BBBHub, iv) molecular mechanisms regulating barrier integrity, v) the role of brain barriers in tumor growth and brain metastases, vi) novel concepts in drug delivery across the brain barriers, and, vii) brain barrier microenvironment in health and disease. The GRC Barriers of the CNS stands out from other brain barriers conferences by bringing together a multidisciplinary group of senior and junior, academic and non-academic, basic and clinical scientists from around the world. The conference provides a protected environment for presenting ongoing and unpublished research promoting new ideas and novel interdisciplinary and translational collaborations. The preceding 2-day “Barriers” GRS is organized by junior investigators at the postdoctoral level and is intended to introduce younger scientists (postgraduate students, post-docs, junior faculty) to the field's methods and issues and to facilitate networking and provide mentorship opportunities. This application addresses a major public health concern, diseases of the CNS. Improving our knowledge regarding brain barrier structure and function is prerequisite to overcome these barriers to achieve appropriate diagnosis and therapy of neurological disorders ranging from brain tumors to Alzheimer's disease, which is presently limited to symptomatic and palliative measures. Instructing young researchers to think of innovative and novel solutions and to bridge disciplinary interfaces will advance the capacity to bring new approaches to realize the untapped potential for the treatment of CNS disease.

项目摘要 /摘要 该建议要求支持2018年“中枢神经系统障碍”部分资金 （CNS）”将于2018年6月16日至17日在新罕布什尔州的科尔比·索耶学院（Colby Sawyer College）举行的GRC和GRS （GRS）和2018年6月17日至22日（GRC）。这次国际会议的总体目标是改善 了解调节功能的高度复杂的细胞和分子机制 内皮（例如血脑屏障（BBB））和上皮（例如，血液-CSF屏障（BCSFB））脑屏障 发展，维护和疾病。 2018年会议将通过涵盖主要方面实现这一目标 中枢神经系统障碍科学以及通过特殊努力包括新的研究方法（例如 晚期插入显微镜，数学建模，生物信息学和生物工程；这将允许 参与者从新角度获得有关脑屏障功能的见解。这一跨学科知识 交流将由受邀的会谈和每日海报演示来培养。 这次会议将从有关大脑障碍在注册CNS免疫中的作用的主题演讲开始 特权并包含有关芯片技术的潮流设定主题演讲，用于生物工程 障碍。另外7次会议将解决：i）脑屏障在中枢神经系统流体流动中的作用，ii）脑屏障 在发育和稳态中，iii）脑屏障生物信息学，包括引入新型数据挖掘 平台，BBBHUB，iv）调节屏障完整性的分子机制，v）脑屏障在 肿瘤生长和脑转移，vi）跨脑屏障药物输送的新概念，vii）大脑 健康和疾病的障碍微环境。 中枢神经系统的GRC障碍通过将 高级和初级，学术和非学术和非学术，基础和临床科学家的多学科小组 世界各地。会议提供了一个受保护的环境，用于展示正在进行的和未发表的环境 研究促进新思想以及新颖的跨学科和翻译合作的研究。 前2天的“障碍” GRS是由初级调查员在博士后一级组织的，IS 旨在将年轻科学家（研究生，毕业后，初级教师）介绍到该领域的 方法和问题，并促进网络并提供指导机会。 该申请解决了CNS疾病的主要公共卫生问题。提高我们的知识 关于大脑屏障结构和功能是克服这些障碍以实现适当的先决条件 从脑肿瘤到阿尔茨海默氏病的神经系统疾病的诊断和治疗， 目前仅限于有症状和姑息治疗措施。指示年轻的研究人员考虑创新 以及新颖的解决方案和桥接纪律界面将提高能力将新方法带入 意识到CNS疾病治疗的未开发的潜力。