2018 Barriers of the CNS Gordon Research Conference and Gordon Research Seminar

2018 CNS戈登研究会议和戈登研究研讨会的障碍

基本信息

批准号：
9542556
负责人：
William Elmquist
金额：
$ 2.39万
依托单位：
GORDON RESEARCH CONFERENCES
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-03-01 至 2019-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9542556
关键词：
Address Alzheimer&apos s Disease Bioinformatics Biomedical Engineering Blood Blood - brain barrier anatomy Blood Circulation Brain Brain Neoplasms Central Nervous System Diseases Clinical Collaborations Communities Complex Computer Simulation Development Diagnosis Diagnostic Disease Drug Delivery Systems Environment Epithelial Faculty Feedback Fostering Funding Goals Growth and Development function Health Homeostasis Immune system International Knowledge Lead Maintenance Measures Mentors Mentorship Metastatic malignant neoplasm to brain Methods Molecular Neuraxis New Hampshire Participant Pharmaceutical Preparations Postdoctoral Fellow Public Health Regulation Request for Applications Request for Proposals Research Research Methodology Research Personnel Role Science Scientist Senior Scientist Structure Students Technology Therapeutic career college data mining fluid flow genetic signature improved innovation insight interest intravital microscopy mathematical model meetings multidisciplinary nervous system disorder neurotoxic new technology novel novel strategies palliative peer posters prevent symposium transcriptome tumor growth

项目摘要

Project Summary / Abstract This proposal requests support for partial funding of the 2018 “Barriers of the Central Nervous System (CNS)” GRC and GRS that will be held at Colby Sawyer College, New Hampshire, on June 16-17, 2018 (GRS) and June 17-22, 2018 (GRC). The overall goal of this international conference is to improve understanding of the highly complex cellular and molecular mechanisms regulating the function of the endothelial (e.g. blood-brain barrier (BBB)) and epithelial (e.g. blood-CSF barrier (BCSFB)) brain barriers in development, maintenance and disease. The 2018 meetings will achieve this goal by covering major aspects of CNS barrier sciences and by making a special effort to include novel research methodology such as advanced intravital microscopy, mathematical modelling, bioinformatics and bioengineering; which will allow participants to obtain insights in brain barrier function from novel angles. This interdisciplinary knowledge exchange will be fostered by invited talks and daily poster presentations. The meeting will start with a keynote session on the role of the brain barriers in regulating CNS immune privilege and conclude with a trendsetting keynote session on chip technology for bioengineering the brain barriers. An additional 7 sessions will address: i) the role of brain barriers in CNS fluid flow, ii) the brain barriers in development and homeostasis, iii) brain barriers bioinformatics including introduction of a novel data-mining platform, the BBBHub, iv) molecular mechanisms regulating barrier integrity, v) the role of brain barriers in tumor growth and brain metastases, vi) novel concepts in drug delivery across the brain barriers, and, vii) brain barrier microenvironment in health and disease. The GRC Barriers of the CNS stands out from other brain barriers conferences by bringing together a multidisciplinary group of senior and junior, academic and non-academic, basic and clinical scientists from around the world. The conference provides a protected environment for presenting ongoing and unpublished research promoting new ideas and novel interdisciplinary and translational collaborations. The preceding 2-day “Barriers” GRS is organized by junior investigators at the postdoctoral level and is intended to introduce younger scientists (postgraduate students, post-docs, junior faculty) to the field's methods and issues and to facilitate networking and provide mentorship opportunities. This application addresses a major public health concern, diseases of the CNS. Improving our knowledge regarding brain barrier structure and function is prerequisite to overcome these barriers to achieve appropriate diagnosis and therapy of neurological disorders ranging from brain tumors to Alzheimer's disease, which is presently limited to symptomatic and palliative measures. Instructing young researchers to think of innovative and novel solutions and to bridge disciplinary interfaces will advance the capacity to bring new approaches to realize the untapped potential for the treatment of CNS disease.

项目概要/摘要该提案要求为 2018 年“中枢神经系统障碍”项目提供部分资助 (CNS)”GRC 和 GRS 将于 2018 年 6 月 16 日至 17 日在新罕布什尔州科尔比索耶学院举行（GRS）和2018年6月17-22日（GRC）本次国际会议的总体目标是改进。了解调节功能的高度复杂的细胞和分子机制内皮细胞（例如血脑屏障（BBB））和上皮细胞（例如血脑脊液屏障（BCSFB））脑屏障 2018年的会议将通过涵盖主要方面来实现这一目标。中枢神经系统屏障科学的研究，并特别努力纳入新颖的研究方法，例如先进的活体显微镜、数学建模、生物信息学和生物工程；参与者从新颖的角度获得对脑屏障功能的见解。将通过邀请演讲和每日海报展示来促进交流。会议将以关于脑屏障在调节中枢神经系统免疫中的作用的主题演讲开始荣幸并以关于大脑生物工程芯片技术的引领潮流的主题演讲结束另外 7 个会议将讨论：i) 脑屏障在中枢神经系统液体流动中的作用，ii) 脑屏障在发育和稳态中，iii）脑屏障生物信息学，包括引入新颖的数据挖掘平台，BBBHub，iv）调节屏障完整性的分子机制，v）脑屏障在肿瘤生长和脑转移，vi) 跨脑屏障药物输送的新概念，以及 vii) 大脑健康和疾病的屏障微环境。 GRC 中枢神经系统障碍 (GRC Barriers of the CNS) 与其他脑障碍会议不同，它汇集了由高级和初级、学术和非学术、基础和临床科学家组成的多学科小组该会议为正在进行的和未发表的演讲提供了一个受保护的环境。研究促进新思想和新颖的跨学科和转化合作。之前为期 2 天的“障碍”GRS 由博士后级别的初级研究人员组织，旨在向年轻科学家（研究生、博士后、初级教师）介绍该领域方法和问题，并促进建立联系并提供指导机会。该应用程序解决了一个主要的公共卫生问题：中枢神经系统疾病。关于脑屏障的结构和功能是克服这些障碍以实现适当的先决条件诊断和治疗从脑肿瘤到阿尔茨海默氏病等神经系统疾病目前仅限于对症治疗和姑息治疗。指导年轻研究人员思考创新措施。新颖的解决方案和桥梁学科接口将提高引入新方法的能力认识到治疗中枢神经系统疾病的未开发潜力。