Epidemiology of the gut microbiome, prediabetes and diabetes in Latinos

拉丁裔肠道微生物组、糖尿病前期和糖尿病的流行病学

• 批准号: 9194787
• 负责人: Robert D Burk
• 金额: $ 82.94万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE, INC
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-08 至 2021-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9194787
• 关键词: Address; Adult; Affect; Age; Ancillary Study; Base Sequence; Behavioral; Bioinformatics; Birth; Blood specimen; Butyrates; Clinical; Collaborations; Cuban; Data; Development; Diabetes Mellitus; Diabetes prevention; Diet; Dietary Practices; Disease; Epidemiological Factors; Epidemiology; Ethnic group; Etiology; Evaluation; Event; Family; Fasting; Feces; Funding; Future; Gender; Genes; Genetic; Genetic Polymorphism; Geographic Locations; Glucose tolerance test; Glycosylated hemoglobin A; Grant; Health; High Prevalence; Hispanic Community Health Study/Study of Latinos; Hispanics; Household; Human; Individual; Insulin; Intervention; Knowledge; Laboratories; Latino; Lead; Letters; Life; Longitudinal Studies; Measurement; Measures; Metabolic; Metabolic Diseases; Metabolic Pathway; Metagenomics; Mexican; Morbidity - disease rate; Not Hispanic or Latino; OGTT; Obesity; Participant; Pattern; Persons; Pharmaceutical Preparations; Play; Population; Prediabetes syndrome; Prevalence; Prevention; Production; Protocols documentation; Puerto Rican; Race; Regulatory Pathway; Relative Risks; Ribosomal RNA; Risk; Risk Factors; Role; Sampling; Site; Study of Latinos; Technology; Testing; Therapeutic Intervention; Time; Variant; authority; carbohydrate metabolism; cohort; design; diabetes risk; diabetic; diabetic patient; diet and exercise; disorder risk; ethnic difference; experience; fasting plasma glucose; follow-up; functional group; genome sequencing; genome wide association study; glucose metabolism; gut microbiome; gut microbiota; indexing; insight; meetings; member; metabolomics; microbial; microbiome; mortality; multidisciplinary; non-diabetic; novel; novel therapeutic intervention; physical inactivity; population based; prevent; prospective; public health relevance; research study; trait; whole genome

The Hispanic/Latino population is the fasting growing segment of the US population. Diabetes disproportionately affects this group. National US 2007-09 data found that >20 yr old Hispanics (11.8%) have a 66% higher rate of diabetes compared to non-Hispanic whites (7.1%). In the population-based Hispanic Community Health Study (HCHS)/Study of Latinos (SOL), diabetes had a baseline prevalence of approximately 17%. Very recent data implicates the gut microbiome (GMB) as a key determinant of diabetes. Since different ancestral populations harbor different diabetes-associated sets of GMBs, it is necessary to study Hispanic/Latino populations with high rates of diabetes to determine the relationship between the GMB and diabetes. Understanding the relationship of the GMB to diabetes is anticipated to lead to a new era of prevention and treatment options, especially since therapeutic interventions are available that target the GMB. Nevertheless, there are major gaps in understanding the epidemiology of the GMB in the population and its role in the development of diabetes. The proposed study will leverage the HCHS/SOL study that will re-examine the participants in 2014-2017. This study has a major focus on diabetes including a fasting 2h glucose tolerance test (GTT), a standardized and universally accepted metric of glucose metabolism, in addition to specific other laboratory and clinical measurements. This proposed ancillary study will test the hypothesis that specific patterns of the gut microbiome will be significantly associated with pre-diabetes and diabetes, building upon recent advances in understanding the importance of the GMB in human health and metabolic diseases. This project will collect and determine the genetic composition of the fecal microbiome from 2,000 cohort members. The proposed study has developed a unique multidisciplinary team to address the following specific aims: (1) to investigate epidemiological factors affecting the gut microbiome in the sample of Hispanic/Latino individuals of diverse background who have normal indices of carbohydrate metabolism. We will test the association of geographic/ancestral background (e.g., Mexican, Puerto Rican), US birth status, gender, age, BMI, shared household and relatedness, and other variables with the GBM composition; (2) to utilize a cross-sectional design to evaluate the association of the gut microbiome (GMB) with the presence of disorders of carbohydrate metabolism including diabetes and prediabetes; and (3) to examine the longitudinal association of the GMB with risk of developing diabetes. We will use the active follow-up in the entire cohort to identify individuals who develop diabetes and estimate the relative risk of disease associated with different microbiomes. We hypothesize that the microbiomes found to be cross-sectionally associated with diabetes in Aim 2 will be predictive of the development of diabetes among initially pre-diabetic and normoglycemic individuals. 1

西班牙裔/拉丁裔人口是美国人口的禁食群。糖尿病 不成比例地影响这一组。美国国家2007-09数据发现，> 20岁的西班牙裔（11.8％） 与非西班牙裔白人相比，糖尿病率高66％（7.1％）。在基于人群的 西班牙裔社区健康研究（HCHS）/拉丁裔研究（SOL），糖尿病的基线患病率是 约17％。最新数据将肠道微生物组（GMB）作为关键决定因素 糖尿病。由于不同的祖先种群具有不同的糖尿病相关的GMB，因此 研究西班牙裔/拉丁裔人群具有高糖尿病率以确定关系的必要条件 在GMB和糖尿病之间。预计了解GMB与糖尿病的关系将会 导致预防和治疗方案的新时代，尤其是因为治疗干预是 可用于针对GMB的可用。然而，理解的流行病学存在很大的差距 GMB人口及其在糖尿病发展中的作用。拟议的研究将利用 HCHS/SOL研究将在2014 - 2017年重新检查参与者。这项研究主要关注 糖尿病包括禁食2H葡萄糖耐量测试（GTT），标准化且普遍接受 除特定的其他实验室和临床测量外，葡萄糖代谢的度量公制。这 拟议的辅助研究将检验以下假设：肠道微生物组的特定模式将是 与糖尿病前和糖尿病相关，基于最新的理解进展 GMB在人类健康和代谢疾病中的重要性。该项目将收集并确定 来自2,000个队列成员的粪便微生物组的遗传组成。拟议的研究有 开发了一个独特的多学科团队来解决以下特定目标：（1）调查 在西班牙裔/拉丁美洲人的样本中影响肠道微生物组的流行病学因素 具有正常碳水化合物代谢指数的背景。我们将测试 地理/祖先背景（例如墨西哥，波多黎各人），美国出生状态，性别，年龄，BMI，共享 家庭与关联性以及其他带有GBM组成的变量； （2）使用横截面 设计评估肠道微生物组（GMB）与存在疾病的疾病的关联 碳水化合物代谢，包括糖尿病和糖尿病前期； （3）检查纵向 GMB的关联与患糖尿病的风险。我们将在整个中使用主动跟进 识别患有糖尿病的个体并估计与疾病相关的相对风险的人群 不同的微生物组。我们假设发现的微生物组与 AIM 2中的糖尿病将预测最初糖尿病和糖尿病的发展 正常血液的个体。 1