Epidemiology of diet, metabolism and non-alcoholic fatty liver disease in Hispanic/Latino adults

西班牙裔/拉丁裔成人饮食、代谢和非酒精性脂肪肝的流行病学

• 批准号: 10735454
• 负责人: Robert D Burk
• 金额: $ 77.27万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-15 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10735454
• 关键词: Address; Adult; Affect; Bacteria; Biological; Biological Markers; Cirrhosis; Clinical; Cohort Studies; Collaborations; Consumption; Data; Diabetes Mellitus; Diet; Diet Modification; Disadvantaged; Disease; Disease Pathway; Ensure; Environment; Epidemiology; Essential Amino Acids; Fatty Liver; Fatty acid glycerol esters; Fibrosis; Fructose; Gastrointestinal tract structure; Genetic Determinism; Genetic Risk; Genetic Variation; High Prevalence; Hispanic; Hispanic Community Health Study/Study of Latinos; Human; Image; Indoles; Inflammation; Infrastructure; Intervention; Intervention Trial; Knowledge; Latin American; Latino; Latino Population; Letters; Life; Literature; Liver; Liver Fibrosis; Liver diseases; Magnetic Resonance Imaging; Malignant neoplasm of liver; Measurement; Measures; Mendelian randomization; Metabolic; Metabolic Diseases; Metabolism; Methodology; Methods; Minority Groups; Modification; Monitor; Obesity; Pharmacotherapy; Population; Poverty; Prevention; Prevotella; Production; Protons; Research; Research Design; Risk; Risk Factors; Risk Reduction; Sample Size; Sampling; Sampling Studies; Serum; Shapes; Stratification; Study of Latinos; Testing; Time; Translating; Tryptophan; Unhealthy Diet; Visit; aged; biobank; burden of illness; case control; cohort; contrast enhanced; cost; data integration; density; diabetes risk; disorder prevention; disorder risk; extracellular; genetic association; gut microbiome; high risk; improved; inter-individual variation; liver imaging; longitudinal analysis; metabolome; metabolomics; metagenomic sequencing; microbiome sequencing; migration; minority subjects; non-alcoholic fatty liver disease; nonalcoholic steatohepatitis; novel; pharmacologic; prevent; preventive intervention; primary outcome; progression risk; response; risk variant; screening; secondary outcome; sex; study population; sugar; therapy design

Abstract Nonalcoholic fatty liver disease (NAFLD) belongs to a cluster of metabolic conditions that disproportionately affects Latinos, the largest US minority group. Known NAFLD risk factors, like obesity, diabetes, poor diet, and genetic risk alleles, are more common in Latino populations, but we don’t fully understand how these factors contribute to Latinos’ high risks of developing NAFLD and its sequelae of non-alcoholic steatohepatitis (NASH), cirrhosis, and liver cancer. Moreover, prior study designs have been largely limited to case-control comparisons focused on clinically recognized disease. This represents only the “tip of the iceberg,” ignoring the large group with subclinical liver disease due to their abundance of risk factors. This proposal will examine host and bacteria produced metabolic products of diet in a large study sample of Latinos (Hispanic Community Health Study – Study of Latinos, N=16,415 adults from four US centers) with state-of-the-art imaging of subclinical liver fibrosis and steatosis. Based upon our results, diet and metabolome features that predict NAFLD may be translated into low-cost risk screening tests. By improving understanding of specific mechanisms, the study may also help to design interventions to prevent NAFLD, by diet modifications or pharmacologic or non-pharmacologic interventions.

抽象的 非酒精性脂肪肝病（NAFLD）属于一系列代谢条件 这对美国最大的少数民族群体拉丁美洲党影响不成比例。已知的nafld 肥胖，糖尿病，饮食不良和遗传风险等位基因等危险因素更为普遍 在拉丁裔人口中，但我们不完全了解这些因素如何促成 拉丁美洲人的高风险及其非酒精性后遗症 脂肪性肝炎（NASH），肝硬化和肝癌。此外，先前的研究设计具有 在很大程度上仅限于临床认可的病例对照比较 疾病。这仅代表“冰山一角”，忽略了大型群体 亚临床肝病由于其丰富的危险因素。该提议将 在大型研究样本中检查宿主和细菌产生饮食的代谢产物 拉丁裔（西班牙裔社区健康研究 - 拉丁裔研究，n = 16,415名成年人 四个美国中心），具有亚临床肝纤维化的最新成像和 脂肪变性。基于我们的结果，饮食和代谢体特征可以预测NAFLD 可以翻译成低成本的风险筛查测试。通过提高对 具体机制，该研究还可能有助于设计干预措施以防止 NAFLD，通过饮食修饰或药理或非药物干预措施。