Biological vector control reducing arboviruses, including Dengue and Chikungunya

生物媒介控制减少虫媒病毒，包括登革热和基孔肯雅热

基本信息

批准号：
9237694
负责人：
James William Mains
金额：
$ 44.42万
依托单位：
MOSQUITOMATE, INC.
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-06-01 至 2018-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9237694
关键词：
Adult Aedes American Samoa Arboviruses Asians Bacteria Biological Biological Assay Biology Bite California Chikungunya virus Collaborations Complex Country Culicidae Data Dengue Disease Disease Vectors Environment Epidemic Epidemiologist Europe Event Female Florida Goals Grant Health India Indigenous Insecticides Intervention Kentucky Legal patent Licensing Longevity Los Angeles Marketing Measures Medical Methods Modeling Monitor Mosquito Control Mosquito-borne infectious disease Native-Born New York Partner in relationship Performance Pharmaceutical Preparations Phase Population Positioning Attribute Practice Management Preparation Production Recommendation Regulatory Pathway Risk Site Sri Lanka Sterility System Technology Tigers Time Vaccines Vision Wolbachia Work chikungunya climate change commercialization cost density design effective therapy epidemiological model fitness improved interest male manufacturing process novel strategies pathogen prototype research and development sex tool transmission process vector vector control vector mosquito

项目摘要

DESCRIPTION (provided by applicant): In the absence of effective, approved drugs or vaccines, vector control remains the only means of intervention for many against mosquito-borne diseases. This problem grows more complex with the recent establishment of multiple exotic mosquito species and mosquito-borne pathogens. Furthermore, changing climate conditions are predicted to alter the traditional range for native mosquitoes. A notable example is Aedes albopictus, the Asian Tiger mosquito, introduced into the USA in the mid-1980s, this invasive species has spread throughout the southeast, and with warmer winters, its range is now moving into New York and other northern states, where it has become the primary biting mosquito. A stable infestation was discovered in California in 2011, which persists despite an ongoing elimination campaign. The cryptic biology of this mosquito makes it difficult to find and treat using traditional insecticidal approaches. In addition to its importance as a biting nuisance A. albopictus is a competent vector of over twenty pathogens. Epidemiological models show risk of returning travelers, infected with chikungunya virus, infecting A. albopictus and starting local transmission. This hypothesized event would be similar to recent epidemics that have occurred in Europe, India, Sri Lanka and La Reunion. Our discussions with major mosquito control districts around the country (California, Florida, New York) demonstrate the need and commercial opportunity for new approaches against A. albopictus and an interest in the our product. Our Phase I results demonstrate feasibility of a Wolbachia biopesticide approach. Repeated releases of Wolbachia- infected males cause a form of conditional sterility, capable of eliminating an A. albopictus population within eight weeks. In the proposed Phase II work, we will continue the research and development of the Wolbachia biopesticide approach, with the major goals of (1) demonstrating a prototype mass production unit, (2) providing field performance data for Wolbachia-infected A. albopictus males, and (3) measuring the pesticidal effect of Wolbachia- infected A. albopictus males against an indigenous field population.

描述（由申请人提供）：在没有有效的，批准的药物或疫苗的情况下，载体控制仍然是许多人针对蚊子传播疾病的唯一干预手段。随着最近建立多种奇异的蚊子和蚊子传播的病原体，这个问题变得更加复杂。此外，预计气候条件的变化会改变天然蚊子的传统范围。一个值得注意的例子是埃德斯白局部，亚洲老虎蚊子，于1980年代中期引入美国，这种入侵物种遍布整个东南部，随着温暖的冬季，它的范围现在正在纽约和其他北部各州，在那里，它已成为主要咬人的蚊子。尽管持续的淘汰运动，但在2011年在加利福尼亚发现了稳定的侵扰。这种蚊子的神秘生物学使得很难使用传统的杀虫剂方法找到和治疗。除了作为刺耳的滋扰曲霉的重要性外，它是二十多种病原体的合格载体。流行病学模型显示出返回旅行者的风险，感染了Chikungunya病毒，感染了白化曲霉并开始局部传播。这一假设的事件将类似于在欧洲，印度，斯里兰卡和La Reunion发生的最近发生的流行病。我们与全国主要蚊子控制区（加利福尼亚州，佛罗里达州，纽约）的讨论表明，对针对白化曲霉的新方法的需求和商业机会以及对我们的产品的兴趣。我们的I阶段结果证明了沃尔巴奇生物农药方法的可行性。沃尔巴氏菌感染的雄性重复释放引起了一种有条件的不育，能够在八周内消除白化曲霉的人群。在拟议的第二阶段工作中，我们将继续进行Wolbachia生物农药方法的研究和开发，其主要目标是（1）证明原型质量生产单元，（2）为沃尔巴奇感染的A. alboptictus雄性提供现场绩效数据，以及（3）测量沃尔巴氏菌感染的白化曲霉雄性对土著田间种群的农药作用。