Development of a Numerical Model for Microbubble Enhanced Treatment in HIFU Therapy

HIFU 治疗中微泡强化治疗数值模型的开发

• 批准号: 9347618
• 负责人: Chao-Tsung Hsiao
• 金额: $ 14.98万
• 依托单位: DYNAFLOW, INC.
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-05-01 至 2017-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9347618
• 关键词: Ablation; Acoustics; Algorithms; Behavior; Benign Prostatic Hypertrophy; Characteristics; Complex; Computer software; Contrast Media; Coupled; Data; Deposition; Development; Equation; Equipment; Focused Ultrasound; Focused Ultrasound Therapy; Goals; Heating; Industry; Injectable; Laboratory Research; Liquid substance; Literature; Malignant Neoplasms; Malignant neoplasm of brain; Malignant neoplasm of liver; Measurement; Medical; Microbubbles; Modeling; Modernization; Operative Surgical Procedures; Pathway interactions; Phase; Physics; Process; Research; Safety; Scheme; Shock; Small Business Innovation Research Grant; Software Framework; Solid Neoplasm; Speed; Technology; Therapeutic; Tissues; Treatment Efficacy; Treatment Protocols; Treatment outcome; Ultrasonic Therapy; Ultrasonics; Ultrasonography; Universities; Validation; Work; base; cancer therapy; clinical practice; computerized tools; design; experimental study; frontier; in vivo; instrument; interest; novel; parallelization; software development; tool

Development of a Numerical Model for Microbubble-Enhanced Treatment in HIFU Therapy High Intensity Focused Ultrasound (HIFU) is currently utilized in many modern therapeutic and surgical medical applications, such as for tissue ablation in the treatment of cancer and benign prostatic hyperplasia. New HIFU research frontier has moved toward the treatment of deep-seated solid tumors such as in liver and brain cancers because HIFU is the only truly noninvasive form of localized ablative therapy. To reduce undesirable pre-focal damage due to induced cavitation activity along the pathway, microbubbles used as ultrasonic contrast agents have been injected to the targeted region to promote heating by utilizing low intensity directed cavitation activity to the focal region. However, the behavior of microbubbles in a focused ultrasound field has not been fully investigated neither experimentally nor numerically due to the complex interactions between the oscillating bubbles and the ultrasound. In this SBIR effort we propose to develop a novel numerical approach to help accurately characterize the acoustic and thermal field with microbubble-enhanced ultrasound for different input characteristics. The numerical approach will employ Eulerian-Lagrangian coupled schemes in which the bubble dynamics are tracked in a Lagrangian fashion while the acoustic and thermal fields are resolved using a fixed grid Eulerian continuum approach. The heat deposition in the HIFU focal region contributed by both the ultrasound acoustic waves and the bubble oscillations will be modeled by solving heat transport equations. The two-way coupled approach allows to predict the nonlinear acoustic field and bubble behaviors accurately and accounts for both bubble-bubble and bubble-fluid interaction. A multi-level parallelization algorithm using both Graphic Processing Unit (GPU) and Central Processing Unit (CPU) computation technology will be implemented to speed up the computations. In Phase I the developed numerical model will be validated against well-documented experimental data available in the literature. In Phase II we will team up with Duke University to conduct ex vivo experiments using real tissue for further validation. The resulting computational tool can be used to help advance the research for microbubble-enhanced HIFU applications. In practice, the tool can be also utilized to explore a wide range of parameters to help selection of instrument setup, and to optimize the design and setting of the HIFU treatment so that higher safety and efficacy of treatments can be reached. The software will also be applicable to the modeling of other controlled cavitation bubbles such as those generated by shock wave lithotripter.

开发用于微生物增强处理的数值模型 HIFU治疗 目前在许多现代治疗中使用高强度的超声（HIFU） 和手术医学应用，例如在癌症治疗和 良性前列腺增生。新的HIFU研究边界已朝着治疗 深处的实体瘤，例如肝脏和脑癌，因为HIFU是唯一的真正 局部消融疗法的无创形式。减少由于 沿途径诱导的空化活性，用作超声造影剂的微泡 已经注入了目标区域，以通过使用低强度的定向来促进加热 对焦点区域的空化活动。但是，微泡的行为在集中 超声场尚未在实验和数字上都没有得到充分研究 振荡气泡与超声之间的复杂相互作用。在这项努力中，我们 建议开发一种新型的数值方法，以帮助准确表征声学和 具有微气泡增强超声的热场，用于不同的输入特性。这 数值方法将采用欧拉 - 拉格朗日耦合方案，其中气泡 动力学以拉格朗日方式跟踪，而声场和热场得到解决 使用固定的网格欧拉连续方法。 HIFU焦点区域的热量沉积 通过超声波和气泡振荡的贡献将建模 通过求解热传输方程。双向耦合方法允许预测 非线性声场和气泡行为准确，并说明两个气泡泡沫 和气泡流体相互作用。使用两个图形的多级并行化算法 处理单元（GPU）和中央处理单元（CPU）计算技术将是 实施以加快计算的速度。在第一阶段，开发的数值模型将是 根据文献中可用的有据可查的实验数据进行了验证。在第二阶段我们 将与杜克大学合作，使用真实组织进行离体实验 验证。由此产生的计算工具可用于帮助推进研究 微泡增强的HIFU应用。实际上，该工具也可以用于探索 广泛的参数，以帮助选择仪器设置，并优化设计和 设置HIFU处理，以便可以达到更高的安全性和疗效。 该软件还适用于其他受控空化气泡的建模 如冲击波岩石纤维产生的那些。