The i♥Rhythm Project: Healthy sleep and behavioral rhythms for obesity prevention

iâ¥节奏项目：预防肥胖的健康睡眠和行为节奏

• 批准号: 9295186
• 负责人: Jennette P Moreno
• 金额: $ 11.06万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-12 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9295186
• 关键词: 8 year old; Address; Age; Behavior Therapy; Behavioral; Bipolar Disorder; Body mass index; Child; Child Rearing; Circadian Rhythms; Climate; Development; Evidence based treatment; Family; Feasibility Studies; Geographic Locations; Goals; Habits; Household and Family; International; Intervention; Knowledge; Longitudinal Studies; Manic; Mediating; Molecular; Monitor; Obesity; Overweight; Parents; Participant; Pattern; Peripheral; Phase; Physical activity; Pilot Projects; Prevention; Research; Resources; Risk; Risk Factors; Role; Sampling; School-Age Population; Schools; Sleep; Sleep Wake Cycle; Standardization; Structure; Students; Technology; Television; Temperature; Time; Training; Variant; Weather; Weight; Weight Gain; behavioral health intervention; career; circadian pacemaker; depressive symptoms; disturbance in affect; elementary school; ethnic diversity; experience; family structure; fifth grade; innovation; kindergarten; mHealth; novel; obesity in children; obesity prevention; obesity risk; prevent; research and development; second grade; social; suprachiasmatic nucleus

PROJECT SUMMARY/ABSTRACT Increases in children's standardized BMI (BMIz) have been demonstrated during summer across the US and internationally. The largest study to demonstrate this was our 5-year longitudinal study (kindergarten – 5th grade) which demonstrated that beginning in early elementary school, children begin a consistent pattern of improvements in BMIz during the school year and significant increases in BMIz during summer, with summertime increases in BMIz contributing to increased risk of becoming overweight or obese by 5th grade. Shortened sleep duration and circadian rhythm disturbances have been clearly implicated in obesity onset. Specifically, shifts in the daily behavioral rhythms of sleep and meal patterns are associated with increased adiposity, mediated through subsequent alterations in the molecular circadian clock. The transition from the school year to summer vacation represents a time during which children may experience changes in their behavioral rhythms (i.e., sleep and behavioral rhythms). Interpersonal Social Rhythm Therapy (IPSRT) is an evidence based treatment for bipolar disorder that has demonstrated efficacy to prevent the reoccurrences of mood disturbances by preventing the misalignment of endogenous circadian rhythms through the promotion of stable behavioral rhythms (e.g., sleep and meal patterns). The goals of the proposed research are to 1) adapt IPSRT to promote stable behavioral rhythms in children during summer vacation for the prevention of summer increases in BMIz (i.e., the i♥rhythm project) and 2) conduct a pilot study to examine the feasibility, acceptability, and preliminary efficacy of the i♥rhythm project to prevent increases in children's BMIz during summer. mHealth technologies will be utilized in order to reach parents using a familiar and convenient resource during out of school times. The K99 phase will provide additional training in order to develop expertise in sleep and circadian rhythms research and the development of behavioral health interventions using mHealth technologies, as well as additional professional and research development needed to address gaps in training. The additional training will facilitate transition to a career focused on the development of behavioral interventions to address the role of sleep and circadian rhythms in the onset of childhood obesity. The proposed research addresses several gaps in scientific knowledge and practice: 1) there are a paucity of interventions addressing summer weight gain in children 2) there is a significant gap in knowledge regarding the role of sleep and circadian rhythms in the prevention of child obesity and 3) addressing summer weight gain provides an important opportunity to address the prevention of child obesity. This innovative application represents a novel application of an intervention with established efficacy to promote stable behavioral rhythms for treatment of bipolar disorder and promises to do the same for the prevention of child obesity. This research is the first to address the role of sleep and circadian rhythms in the prevention of child obesity and to examine the preliminary evidence of such an intervention on the long-term prevention of obesity.

项目摘要/摘要 在美国夏季，已经证明了儿童标准化BMI（BMIZ）的增加 国际。最大的研究证明了这是我们5年的纵向研究（幼儿园 - 第五次 等级）表明从早期小学开始，孩子们开始了一致的模式 学年中BMIZ的改善，夏季BMIZ的大幅增加，其中 BMIZ的夏季增加有助于增加五年级的超重或肥胖的风险。 肥胖发作中已经明确实施了睡眠持续时间和昼夜节律疾病。 具体而言，每日睡眠和进餐方式的行为节奏的变化与增加有关 肥胖，通过随后的分子昼夜节律改变而介导。从 学年到暑假代表儿童可能会发生变化的时期 行为节奏（即睡眠和行为节奏）。人际社会节奏疗法（IPSRT）是 基于证据的双相情感障碍治疗，这表明了效率以防止再次发生 情绪障碍通过促进内源性昼夜节律的不对对准而进行情绪障碍 稳定的行为节奏（例如，睡眠和膳食模式）。拟议研究的目标是1）适应 IPSRT在暑假期间促进儿童稳定的行为节奏，以预防夏季 BMIZ的增加（即I♥节奏项目）和2）进行试点研究以检查可行性， I♥节奏项目的可接受性和初步效率，以防止儿童BMIZ在 夏天。将使用MHealth Technologies来使用熟悉且方便的 在毕业时期的资源。 K99阶段将提供额外的培训以开发 睡眠和昼夜节律研究的专业知识以及行为健康干预的发展 使用MHealth Technologies，以及需要解决的其他专业和研究开发 培训中的差距。额外的培训将有助于过渡到专注于发展的职业 行为干预措施，以解决睡眠和昼夜节律在儿童对象开始中的作用。 拟议的研究解决了科学知识和实践中的几个差距：1）很少 解决儿童夏季体重增加的干预措施2）关于 睡眠和昼夜节律在预防儿童物体中的作用和3）解决夏季体重 收益提供了一个重要的机会来解决预防儿童财产。这种创新的应用 代表具有既定效率的干预措施的新应用，以促进稳定的行为节奏 为了治疗躁郁症，并有望为预防儿童肥胖而做同样的事情。这项研究 是第一个解决睡眠和昼夜节律在预防儿童肥胖症中的作用并检查的人 对长期预防肥胖症进行这种干预的初步证据。