Southern California Network Clinical Center (Hub) for SIREN Emergency Care Clinical Trails

SIREN 紧急护理临床试验南加州网络临床中心（中心）

基本信息

批准号：
9284308
负责人：
JEFFREY L SAVER
金额：
$ 25.71万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-07-15 至 2022-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9284308
关键词：
Academic Medical Centers Accident and Emergency department Acute Adult Affect African American Ambulances American Area Brain California Cardiac Cardiopulmonary Arrest Caring Cessation of life Child Clinical Clinical Trials Clinical Trials Network Collaborations County Data Quality Diagnosis Discipline Disease Emergency Care Emergency Department Physician Emergency Medicine Emergency Situation Emergency research Emergency treatment Employee Strikes Ensure Event Goals Heart failure Hematologist Hemorrhagic Shock Hispanic Americans Hospitalists Hospitals Impairment Individual Injury Inpatients Interdisciplinary Study Intervention Knowledge Lead Leadership Life Los Angeles Magnesium Marshal Medical Medical center Medicine Multi-Institutional Clinical Trial Myocardial Ischemia Nervous System Trauma Nervous system structure Neurologic Neurological emergencies Neurologist Neurosurgeon Nurses Operative Surgical Procedures Oranges Paramedical Personnel Patient-Focused Outcomes Patients Personnel Staffing Physicians Population Pragmatic clinical trial Provider Pulmonary Embolism Recovery Research Research Infrastructure Research Personnel Research Training Resources Resuscitation Self Perception Specialist Status Epilepticus Stroke System Time Time Study Trauma Underrepresented Populations United States United States National Institutes of Health Woman care systems clinical care clinical practice decision-making capacity disability experience flexibility improved outcome innovation medical specialties meetings novel strategies outreach patient population performance site respiratory stroke therapy success translational study treatment trial trial design

项目摘要

Medical and traumatic emergency conditions affecting the cardiac, respiratory, nervous, and hematologic systems collectively account for the overwhelming preponderance of death and disability affecting Americans. It is imperative that new approaches for timely diagnosis and treatment of these conditions treatments be efficiently developed. This application is to form a Southern California Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SoCal SIREN) Hub and Spoke system that will conduct high-quality, multi-site clinical trials to improve the outcomes for patients with neurologic, cardiac, respiratory, and hematologic, and trauma emergency events. The SoCal SIREN consortium will marshal all six academic medical centers in the region (UCLA, Harbor-UCLA, USC, UCI, UCSD, and Cedars-Sinai); all 3 County EMS agencies [Los Angeles EMS (lead), Orange County EMS (co-lead), and San Diego County EMS (flexible)], and up to 83 potential performance sites (1 Hub, 5 Core Spoke, 16 Additional Spoke, and 61 Flexible Spoke) Medical Centers in Southern California, experienced in performing emergency clinical trials efficiently and excellently. Eleven Advisory Panels with expertise in specific disease and research domains will facilitate trial implementation within the Network and serve as a resource to the Hub leadership and to individual performance sites. The four specific aims of this proposal are to: 1) perform high-quality pragmatic clinical trials in several different types of emergency disorders afflicting adults or children throughout Southern California; 2) facilitate collaboration between emergency medicine physicians and disease specialists throughout Southern California in trial design and execution high quality NSTN recovery and rehabilitaiton trials throughout Los Angeles and Orange Counties; 3) facilitate collaboration between the prehospital EMS system and acute receiving hospitals, including specialty receiving centers in trauma, stroke, and cardiac resuscitation, throughout Southern California in trial design and execution; and 4) ensure participation of a substantial number of patients with emergency conditions in SIREN clinical trials, including women, children, Hispanic-Americans, African-Americans, and other traditionally underrepresented populations.

影响心脏，呼吸系统，神经和血液学系统的医疗和创伤性紧急情况总体上说明了影响美国人的死亡和残疾的压倒性大量。当务之急有效开发了及时诊断和治疗这些疾病治疗的新方法。该申请是构成南加州的策略，以创新急诊临床试验网络（SOCAL SIREN）集线器和辐条系统，将进行高质量的多站点临床试验以改善神经系统，心脏，呼吸道和血液学和创伤紧急事件的患者的结局。 SoCal 警笛财团将在该地区所有六个学术医疗中心（UCLA，Harbour-Ucla，USC，UCI，UCI， UCSD和Cedars-Sinai）;所有3个县EMS机构[洛杉矶EMS（Lead），Orange County EMS（共同领导）和SAN 迭戈县EMS（灵活）]，以及最多83个潜在的性能站点（1个枢纽，5个核心讲座，另外16个辐条和 61个灵活的辐条）南加州的医疗中心，在执行紧急临床试验方面经验丰富有效而出色。 11个咨询面板在特定疾病和研究领域具有专业知识将有助于网络内的试验实施，并充当枢纽领导力和个人性能站点的资源。该提案的四个具体目标是：1）在几种不同的不同在整个南加州，困扰成人或儿童的紧急疾病类型； 2）促进协作急诊医学医师和整个南加州的疾病专家在试验设计中在洛杉矶和橙色县进行高质量的NSTN恢复和康复试验； 3）便利院前EMS系统与急性接收医院之间的合作，包括专业接收中心整个加利福尼亚州的创伤，中风和心脏复苏在试验设计和执行方面； 4）确保参与警笛临床试验（包括女性）的大量紧急情况患者的参与儿童，西班牙裔美国人，非裔美国人和其他传统代表性不足的人群。