Southern California Network Clinical Center (Hub) for SIREN Emergency Care Clinical Trails

SIREN 紧急护理临床试验南加州网络临床中心（中心）

基本信息

批准号：
10200906
负责人：
JEFFREY L SAVER
金额：
$ 14.83万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-07-15 至 2022-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10200906
关键词：
Academic Medical Centers Accident and Emergency department Acute Adult Affect African American Ambulances American Area Brain California Cardiac Cardiopulmonary Arrest Cardiopulmonary Resuscitation Cessation of life Child Clinical Clinical Trials Clinical Trials Network Collaborations County Data Diagnosis Discipline Disease Emergency Care Emergency Department Physician Emergency Medicine Emergency Situation Emergency research Emergency treatment Ensure Event Goals Heart failure Hematologist Hematology Hemorrhagic Shock Hispanic Americans Hospitalists Hospitals Impairment Individual Infrastructure Injury Inpatients Interdisciplinary Study Intervention Knowledge Lead Leadership Life Los Angeles Magnesium Marshal Medical Medical center Medicine Multi-Institutional Clinical Trial Myocardial Ischemia Nervous System Trauma Nervous system structure Neurologic Neurological emergencies Neurologist Neurosurgeon Nurses Operative Surgical Procedures Oranges Paramedical Personnel Patient-Focused Outcomes Patients Personnel Staffing Physicians Population Pragmatic clinical trial Provider Pulmonary Embolism Recovery Research Research Personnel Research Training Resources Self Perception Specialist Status Epilepticus Stroke System Time Time Study Trauma Underrepresented Populations United States United States National Institutes of Health Woman acute care care systems clinical care clinical center clinical practice decision-making capacity disability emergency settings experience flexibility improved outcome innovation medical specialties meetings novel strategies outreach patient population performance site respiratory stroke therapy success translational study treatment trial trial design

项目摘要

Medical and traumatic emergency conditions affecting the cardiac, respiratory, nervous, and hematologic systems collectively account for the overwhelming preponderance of death and disability affecting Americans. It is imperative that new approaches for timely diagnosis and treatment of these conditions treatments be efficiently developed. This application is to form a Southern California Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SoCal SIREN) Hub and Spoke system that will conduct high-quality, multi-site clinical trials to improve the outcomes for patients with neurologic, cardiac, respiratory, and hematologic, and trauma emergency events. The SoCal SIREN consortium will marshal all six academic medical centers in the region (UCLA, Harbor-UCLA, USC, UCI, UCSD, and Cedars-Sinai); all 3 County EMS agencies [Los Angeles EMS (lead), Orange County EMS (co-lead), and San Diego County EMS (flexible)], and up to 83 potential performance sites (1 Hub, 5 Core Spoke, 16 Additional Spoke, and 61 Flexible Spoke) Medical Centers in Southern California, experienced in performing emergency clinical trials efficiently and excellently. Eleven Advisory Panels with expertise in specific disease and research domains will facilitate trial implementation within the Network and serve as a resource to the Hub leadership and to individual performance sites. The four specific aims of this proposal are to: 1) perform high-quality pragmatic clinical trials in several different types of emergency disorders afflicting adults or children throughout Southern California; 2) facilitate collaboration between emergency medicine physicians and disease specialists throughout Southern California in trial design and execution high quality NSTN recovery and rehabilitaiton trials throughout Los Angeles and Orange Counties; 3) facilitate collaboration between the prehospital EMS system and acute receiving hospitals, including specialty receiving centers in trauma, stroke, and cardiac resuscitation, throughout Southern California in trial design and execution; and 4) ensure participation of a substantial number of patients with emergency conditions in SIREN clinical trials, including women, children, Hispanic-Americans, African-Americans, and other traditionally underrepresented populations.

影响心脏、呼吸、神经和血液系统的医疗和创伤紧急情况共同解释了影响美国人的绝大多数死亡和残疾问题。当务之急是有效开发及时诊断和治疗这些疾病的新方法。该申请旨在形成南加州创新紧急护理临床试验战略网络（SoCal SIREN）中心辐射系统将进行高质量的多站点临床试验，以改善患有神经、心脏、呼吸、血液和创伤紧急事件的患者的结果。南加州 SIREN 联盟将整合该地区所有六个学术医疗中心（加州大学洛杉矶分校、加州大学洛杉矶分校港口分校、南加州大学、加州大学尔湾分校、加州大学圣地亚哥分校 (UCSD) 和雪松西奈分校 (Cedars-Sinai)；所有 3 个县 EMS 机构 [洛杉矶 EMS（牵头）、奥兰治县 EMS（共同牵头）和圣迭戈县 EMS（灵活）]，以及多达 83 个潜在性能站点（1 个中心、5 个核心辐条、16 个附加辐条和南加州 61 个灵活辐条医疗中心，在执行紧急临床试验方面经验丰富高效、优秀。十一个在特定疾病和研究领域具有专业知识的咨询小组将促进在网络内进行试验实施，并作为中心领导层和各个绩效站点的资源。该提案的四个具体目标是：1）在几个不同的国家进行高质量的实用临床试验影响整个南加州成人或儿童的紧急疾病类型； 2）促进协作整个南加州的急诊科医生和疾病专家之间进行试验设计和在洛杉矶和奥兰治县执行高质量的 NSTN 恢复和康复试验； 3）方便院前 EMS 系统与急症接收医院（包括位于以下城市的专科接收中心）之间的合作整个南加州的创伤、中风和心脏复苏的试验设计和执行； 4) 确保大量患有紧急情况的患者（包括女性）参与了 SIREN 临床试验，儿童、西班牙裔美国人、非裔美国人和其他传统上代表性不足的人群。