Driving Biomedical Projects

推动生物医学项目

• 批准号: 9280024
• 负责人: Joanna R Long
• 金额: $ 4.84万
• 依托单位: FLORIDA STATE UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9280024
• 关键词: Address; Area; Automobile Driving; Awareness; Beds; Biological; Biomedical Research; Biomolecular Nuclear Magnetic Resonance; Cell Nucleus; Collection; Communities; Data Analyses; Data Collection; Detection; Development; Disease; Ensure; Evaluation; Experimental Designs; Feedback; Fostering; Home environment; Hybrids; Individual; Institution; Isotopes; Membrane Proteins; Nuclear; Performance; Physiologic pulse; Preparation; Proteins; Recruitment Activity; Research; Research Personnel; Research Project Grants; Resolution; Resources; Role; Sampling; Series; Techniques; Technology; Testing; Training; Translating; United States National Institutes of Health; computerized data processing; design; enzyme mechanism; experimental study; grasp; high sensitivity probe; improved; insight; instrumentation; interest; magnetic field; metabolomics; next generation; programs; technology development

Driving Biomedical Projects Project Summary/Abstract We have identified thirteen driving biomedical projects for the National Resource for Advanced NMR Technology BTRR. These projects are led by PIs who are leaders in NMR technology development in their own regard and who are at the forefront of new and exciting biomedical research applications. This ensures that they will actively participate in technology development, experimental design, and developing data collection and analysis strategies. They will also provide immediate and insightful feedback on technology performance. For the DBPs we have three specific aims: 1) Demonstrate capabilities and provide evaluation for ultrasensitive cryoprobe technologies developed by TR&D1; 2) Demonstrate capabilities and provide evaluation for dynamic nuclear polarization (DNP) technologies developed by TR&D2; and 3) Demonstrate capabilities and provide evaluation for series connected hybrid (SCH) magnet technologies developed by TR&D3. Many of the DBPs will be actively involved with two or even three of the TR&D projects. This wide ranging engagement fosters the proliferation of ideas and techniques between the various projects. The DBPs are characterized by research that is at the forefront of the NMR field in developing new techniques and applying them to extremely challenging biomedical research problems. Many of them have the most advanced commercial NMR technology available at their home institutions, and are pushing the boundaries of sensitivity and resolution with creative approaches to NMR pulse sequences, sample preparation strategies, and data processing and analysis. They are all keenly aware of the need for improved capabilities, particularly through implementing higher magnetic fields, developing the highest sensitivity probes possible, and pursuing dynamic nuclear polarization as an orthogonal strategy to improve sensitivity. We have long standing relationships with many of the DBP contributors, as collaborators and users of the NHMFL facilities ensuring lively and productive dialogue. We view the collection of DBPs we have assembled as the best suited to push devel- opment of the TR&D's with biomedical research programs in five primary areas of interest to the NIH: intrinsi- cally disordered proteins, membrane proteins, protein assemblies, enzyme mechanisms and metabolomics. Collectively, the technology developments proposed through the TR&Ds are paramount to advancing the sensitivity and resolution needed to address vanguard biomedical questions posed by the DBPs, and through the guidance of the DBPs we will pioneer the next step in NMR technology.

驱动生物医学项目 项目摘要/摘要 我们已经确定了13个为高级NMR国家资源的驾驶生物医学项目 技术BTRR。这些项目是由PI领导的，他们是NMR技术开发领域的领导者 自己的尊重以及谁在新的和令人兴奋的生物医学研究应用中处于最前沿。这确保了 他们将积极参与技术开发，实验设计和开发数据 收集和分析策略。他们还将提供有关技术的立即和有见地的反馈 表现。对于DBP，我们有三个具体的目标：1）演示功能并提供评估 用于TR＆D1开发的超敏感冷冻探针技术； 2）展示功能并提供 TR＆D2开发的动态核极化（DNP）技术评估; 3）演示 功能并提供评估由串联连接的混合动力车（SCH）磁铁技术开发的 TR＆D3。许多DBP将积极参与两个TR＆D项目。这么宽 参与度促进了各个项目之间思想和技术的扩散。 DBP 在开发新技术和 将它们应用于极具挑战性的生物医学研究问题。他们中的许多人最先进 商业NMR技术可在他们的家庭机构中获得，并正在推动敏感性的界限 以及以创造性的方法来解决NMR脉冲序列，样本准备策略和数据 处理和分析。他们都敏锐地意识到需要提高能力，尤其是通过 实施较高的磁场，开发最高灵敏度探针并追求动态 核极化是提高灵敏度的正交策略。我们与 许多DBP贡献者，作为NHMFL设施的合作者和用户，可确保活泼和活泼 富有成效的对话。我们认为我们已组装的DBP集合是最适合推动Devel-的收集。 NIH感兴趣的五个主要领域的生物医学研究计划对TR和D的行动：内在 结实的蛋白质，膜蛋白，蛋白质组件，酶机制和代谢组学。 总的来说，通过TR＆D提出的技术发展对于推进 敏感性和解决方案需要解决DBP提出的先锋生物医学问题，并通过 DBP的指导我们将开拓NMR技术的下一步。