Console upgrade for microimaging and solid state NMR spectroscopy at 600 MHz

600 MHz 微成像和固态 NMR 光谱控制台升级

基本信息

批准号：
8052232
负责人：
Joanna R Long
金额：
$ 44.99万
依托单位：
UNIVERSITY OF FLORIDA
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-03-15 至 2013-03-14
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): Funds are requested for the replacement of an 11 year old NMR console for a 600 MHz NMR spectrometer located in the Advanced Magnetic Resonance Imaging and Spectroscopy Facility at the University of Florida. The current Bruker DRX console, primarily utilized for high resolution microimaging and solid state NMR experiments, is technically limited relative to next generation consoles and is beginning to break down on a frequent basis, with several components no longer supported by the vendor. Funds are requested to replace this aging console with a Bruker Avance III console. In addition to enhancing the reliability of the NMR equipment, the new console and integrated software are expected to have enhanced technical capabilities and improved performance relative to our current console. The AMRIS Facility supports a broad range of NIH-funded research projects with four dedicated technical staff having expertise in microimaging, NMR spectroscopy, and animal MRI and over 60 years of experience working in biological MR research. The new console is critical to the success of the NIH-funded research of both a group of eight major users (S. Blackband, G. Fanucci, J. Long, T. Mareci, M. Sarntinoranont, N. Simpson, B. Vemuri, and G. Walter), all of whom are experts in microimaging and/or biomolecular NMR, and of minor users (including M. Raizada, E. Scott, and D. Steindler). These user groups undertake studies that are extremely demanding from an imaging and spectroscopy standpoint, including measurements of tissue structure and diffusion at cellular resolution and measurements of biomolecular structure and dynamics via solid state NMR spectroscopy. A number of the projects are of direct relevance to the diagnosis and treatment of human disease. PUBLIC HEALTH RELEVANCE: Magnetic resonance imaging and spectroscopy is a powerful continuum of techniques used to study the three-dimensional structures, diffusion, and molecular structure and dynamics in biological systems. A number of NIH-supported investigators at the University of Florida utilize magnetic resonance techniques to study biological tissues and biomolecules of relevance to human health and disease. Funds are requested to replace out-of-date MRI/S equipment with state-of-the-art equipment to ensure continued progress of the biological and biomedical research programs of the investigators associated with this application and a larger community of additional users who also rely on MR in their investigations.

描述（由申请人提供）：要求资金用于在佛罗里达大学的先进磁共振成像和光谱仪设施中更换1100年历史的NMR控制台。当前的Bruker DRX控制台主要用于高分辨率显微成像和固态NMR实验，在技术上相对于下一代游戏机在技术上受到限制，并且开始频繁地分解，而供应商不再支持几个组件。要求资金用Bruker Avance III控制台替换此老化控制台。除了提高NMR设备的可靠性外，新的控制台和集成软件还有望具有增强的技术功能，并且相对于我们当前的控制台提供了提高的性能。 AMRIS设施支持广泛的NIH资助研究项目，四名专门的技术人员在微型成像，NMR光谱和动物MRI方面具有专业知识，以及在生物学MR研究中工作的60多年的经验。新的控制台对于NIH资助的八个主要用户的成功至关重要（S. Blackband，G。Fanucci，J。Long，T。Mareci，M。Sarntinoranont，N。Simpson，B。Vemuri和G. Walter），所有这些都是微型培训和/或Biomolecular nmr和Minecare and craute and craute and craute and crapt and e。从成像和光谱的角度来看，这些用户组进行了极为要求的研究，包括测量组织结构以及通过固态NMR光谱的细胞分辨率和生物分子结构和动力学的测量。许多项目与人类疾病的诊断和治疗直接相关。公共卫生相关性：磁共振成像和光谱是一种强大的技术，用于研究生物系统中三维结构，扩散以及分子结构和动力学。佛罗里达大学的许多NIH支持的研究人员利用磁共振技术来研究与人类健康和疾病相关的生物组织和生物分子。要求资金用最先进的设备替换过时的MRI/S设备，以确保与此应用程序相关的研究人员的生物和生物医学研究计划以及更大的其他用户社区的持续进展，这些用户也依靠MR进行调查。