Training Program in Imaging Sciences in Translational Cardiovascular Research

转化心血管研究成像科学培训项目

• 批准号: 9264011
• 负责人: Flordeliza S Villanueva
• 金额: $ 31.9万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9264011
• 关键词: Cardiovascular system; Image; Research; Science; Training Programs

 DESCRIPTION (provided by applicant): Capabilities for biologic imaging at all levels--spanning molecules to man--have evolved to an unprecedented level of sophistication such that we can now visualize anatomic, functional, cellular, and molecular processes heretofore invisible, opening exciting new opportunities to study disease pathogenesis. In order for this ever- growing capacity to "see," to facilitate bedside translation of scientific discoveries, images must understand what questions are important in biomedical research, and conversely, biomedical scientists must be fluent in the imaging technologies that could revolutionize their work. However, there is a paucity of scientists who can comfortably commute between the spheres of imaging science and biomedical research, resulting in a "disconnect" that stymies what should otherwise be a powerful, bi-directionally facilitative, relationship between imaging science and translational research. To close this chasm, our new T32 Program employs an innovative educational paradigm to train future clinical and basic researchers in a broad spectrum of cutting edge, multimodality imaging platforms as they pursue hypothesis-driven research, with a specific emphasis on translational cardiovascular research. While there are T32's focused on traditional cardiovascular imaging tools (e.g. MRI, SPECT, Echo), to our knowledge, no training program comprehensively integrates biological imaging within translational biological and physical sciences. Our post-doctoral trainees (MD or PhD) will acquire "core competencies" in imaging methods spanning molecular to whole organism ("imaging tool kit") and in the conduct of translational research spanning basic to population levels ("translational tool kit') -- accomplished through a co-mentorship structure, with each trainee having one mentor from the imaging sciences, and another from the biomedical science arena. Our training strategy is structured around Individualized Development Plans that emphasize quantifiable outcomes based on abstract presentations, publications, pursuit of career development grants, completion of didactic courses, or completion of Masters Programs. The Director, Dr. Villanueva, is a cardiologist, imaging specialist, and translational researcher with extensive mentoring experience. In actualizing the reciprocal relationship between imaging sciences and biomedical research espoused by this T32, she has been at the forefront of molecular probe and ultrasound technology development for molecular imaging and therapeutics. Our Training Committee comprises the Director and 3 co-Directors with expertise in basic, translational, and clinical research and training. Our 15 Imaging Faculty embody the full gamut of state-of-the-art imaging technologies, and 16 Biomedical Science Faculty offer multiple levels of translational research topics in cardiovascular medicine. The Program is enhanced by institutional endowments to Cardiology and the Heart, Lung, Blood, and Vascular Medicine Institute (VMI), a rich infrastructure from the Clinical Sciences Translational Institute and Cente for Ultrasound Molecular Imaging and Therapeutics, VMI Cores, and interactions with other institutional translational T32s.

 描述（由适用提供）：在所有级别的生物成像的能力 - 跨分子的人体 - 散布到前所未有的复杂发现水平，例如我们现在可以可视化解剖学，功能性，细胞和分子过程，以实现疾病病原体的兴奋的新机会，使人们能够看到令人兴奋的新机会。为了使这种不断增长的“看到”能力促进科学发现的床边翻译，图像必须了解哪些问题在生物医学研究中很重要，相反，生物医学科学家必须在成像技术中流利，这可以改变其工作。但是，很少有科学家能够在成像科学和生物医学研究领域之间舒适地上下班，从而导致“脱节”，这阻碍了原本应该是强大，双向友好的成像科学与翻译研究之间的关系。为了结束这一鸿沟，我们的新T32计划员工是一种创新的教育范式，以培训未来的临床和基础研究人员，以广泛的尖端，多模态成像平台进行假设驱动的研究，并特别强调翻译的心血管研究。据我们所知，虽然T32的重点是传统的心血管成像工具（例如MRI，SPECT，ECHO），但没有培训计划将生物成像全面整合到翻译的生物学和物理科学中。我们的博士后学员（MD或PHD）将在成像方法中获得“核心能力”，这些方法涵盖了整个有机体（“成像工具套件”），并在经过基本人口水平的翻译研究（“转化工具工具包”）的进行中，通过每种培训的训练，我们的训练是一个训练，我们的训练是一个训练，我们的训练是一个训练，我们的训练是我们的另一个训练，我们的训练和训练是我们的另一个训练。围绕个性化的开发计划，这些计划强调了基于抽象的演示，出版物，追求职业发展赠款，完成教学课程或完成硕士课程的完成。在分子探针和超声技术开发的最前沿，用于分子成像和治疗。我们的培训委员会由董事和3个联合导演组成，具有基础，翻译和临床研究和培训方面的专业知识。我们的15个成像教师体现了完整的 最先进的成像技术和16个生物医学科学教师提供了心血管医学的多个转化研究主题。心脏病学和心脏，肺，血液和血管医学研究所（VMI）的机构捐赠增强了该计划，临床科学转化研究所的丰富基础设施以及超声分子成像和治疗疗法的百分之十，VMI核心，VMI核心，VMI核心，VMI核心，以及与其他机构翻译T32S的相互作用。