Training Program in Imaging Sciences in Translational Cardiovascular Research

转化心血管研究成像科学培训项目

• 批准号: 10633063
• 负责人: Flordeliza S Villanueva
• 金额: $ 34.48万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10633063
• 关键词: Cardiovascular system; Image; Research; Science; Training Programs

Advances in imaging technology lead to discoveries in science and medicine. Conversely, pressing questions in science and medicine drive innovation in imaging technology development, underscoring the fundamental symbiosis between imaging and biomedical research. The necessity to connect imaging and biomedical science is particularly salient in cardiovascular research, where imaging the heart and vascular system, from whole organ to molecular levels, figures prominently in the translation of discoveries to bedside diagnosis and treatment. As such, imaging scientists must understand what questions are important in biomedical research, while biomedical scientists must be fluent in the imaging technologies that can facilitate discovery. Our inaugural T32 program (2016)– the first in Cardiology at University of Pittsburgh – was motivated by the recognition that there is a paucity of scientists who can adeptly commute between the imaging science and biomedical research spheres, ultimately compromising the translational relevance of research efforts, and contributing to the “Valley of Death” separating basic discovery and clinical application. To bridge this chasm, our new T32 Program used an innovative educational paradigm to train clinical and basic researchers in a broad spectrum of cutting-edge, multimodality imaging platforms as they pursue hypothesis-driven research, with an emphasis on translational cardiovascular research. While T32s at other institutions focus on traditional cardiovascular imaging tools (e.g., MRI, Echo), our T32 is unique in integrating biological imaging within the biological and physical sciences. Our program was designed such that post-doctoral trainees (MD or PhD) acquire “core competencies” in imaging methods spanning molecular to whole organism (“imaging tool kit”), and translational research methods spanning basic to population levels (“translational tool kit’) – accomplished through a co-mentorship structure, with each trainee having one mentor from imaging sciences and another from the biomedical science arena. Our approach is structured around Individualized Development Plans that have quantifiable milestones, e.g., presentations, publications, grants, didactic courses, or completion of Master’s degrees. Now 4.2 years into our first funding cycle, we seek competitive renewal of our program based on its compelling premise and unmet training need; its occupancy of an important niche in the NHLBI portfolio (only 2% of NHLBI T32s are imaging-focused); the 37 excellent, scientifically diverse, well-funded training faculty; and the successful outcomes of our nascent program thus far. In our 2019 Cardiology Fellowship match for 8 positions (>700 applicants), 4 were filled by MDs committed to our T32 program, highlighting our mandate to train future MD scientists. Dr. Villanueva, a cardiologist, imaging specialist, and researcher with extensive mentoring experience, has ably led our young program alongside 3 seasoned co-Directors and Advisory Boards. Our T32 is enhanced by institutional endowments, research Cores of the Heart, Lung, Blood, and Vascular Medicine Institute, a rich infrastructure from the Clinical Sciences Translational Institute, and interactions with other institutional translational T32s.

成像技术的进步导致科学和医学的发现。相反，在 科学和医学推动成像技术开发的创新，强调了基本 成像和生物医学研究之间的共生。连接成像和生物医学科学的必要条件 在心血管研究中尤为重要，其中整个器官都会成像心脏和血管系统 到分子水平，在发现为床边诊断和治疗的转换中显着的数字。作为 这样的成像科学家必须了解哪些问题在生物医学研究中很重要，而生物医学 科学家必须精通可以促进发现的成像技术。我们的首届T32计划 （2016年） - 匹兹堡大学心脏病学的第一个 - 受到认识的激励 可以在成像科学和生物医学研究领域之间进行熟练通勤的科学家 最终损害了研究工作的转化相关性，并为“死亡谷”做出了贡献 分开基本发现和临床应用。为了弥合这种鸿沟，我们的新T32程序使用了 创新的教育范式培训各种临床和基础研究人员， 多模式成像平台在追求假设驱动的研究时，重点是翻译 心血管研究。尽管其他机构的T32专注于传统的心血管成像工具（例如， MRI，Echo），我们的T32在将生物学成像整合到生物学和物理科学中是独一无二的。我们的 计划的设计使博士后学员（MD或PHD）在成像中获得了“核心能力” 跨越分子到整个生物体的方法（“成像工具套件”），并翻译的研究方法跨越 人口水平的基础（“转化工具套件”） - 通过会议结构完成 受训者从成像科学和另一个来自生物医学科学领域的精神。我们的方法 围绕具有可量化里程碑的个性化开发计划，例如演示， 出版物，赠款，教学课程或硕士学位的完成。现在进入我们的第一个资金已有4。2年了 循环，我们基于其令人信服的前提和未满足的培训需求寻求竞争性续约； 它在NHLBI投资组合中占有重要的利基（NHLBI T32中只有2％是以成像为中心的）； 37 优秀，科学多样，资金充足的培训教师；以及我们新生计划的成功结果 在我们2019年的8个职位（> 700名申请人）的2019年心脏病学奖学金比赛中，有4名由MDS填补 致力于我们的T32计划，强调了我们培训未来MD科学家的任务。 Villanueva博士，a 心脏病专家，成像专家和具有丰富心理经验的研究人员，很好地领导了我们的年轻人 与3个经验丰富的联合主管和咨询委员会一起计划。我们的T32通过机构增强 丰富的基础设施的end赋，心脏，肺，血液和血管医学研究所 来自临床科学转化研究所，以及与其他机构翻译T32的相互作用。

项目成果

Cardiovascular Hospitalizations and Resource Use Following Atrial Fibrillation Ablation.

• DOI: 10.1161/jaha.122.028609
• 发表时间: 2023-09-19
• 期刊: JOURNAL OF THE AMERICAN HEART ASSOCIATION
• 影响因子: 5.4
• 作者: Dhande, Mehak;Barakat, Amr;Canterbury, Ann;Thoma, Floyd;Mulukutla, Suresh;Sezer, Ahmet;Aronis, Konstantinos N.;Bhonsale, Aditya;Kancharla, Krishna;Voigt, Andrew H.;Wang, Norman C.;Shalaby, Alaa;Mark Estes, N. A., III;Saba, Samir;Jain, Sandeep K.
• 通讯作者: Jain, Sandeep K.

White Coat Hypertension in Pregnancy: The Challenge of Combining Inconsistent Data.

妊娠期白大衣高血压：合并不一致数据的挑战。

• DOI: 10.1161/hypertensionaha.120.15056
• 发表时间: 2020
• 期刊: Hypertension (Dallas, Tex. : 1979)
• 作者: Roberts,JamesM;Countouris,Malamo
• 通讯作者: Countouris,Malamo

Sex Differences in Myocardial Histology, Gene Expression, and Myocardial Recovery in Recent-Onset Cardiomyopathy.

新发心肌病心肌组织学、基因表达和心肌恢复的性别差异。

• DOI: 10.1016/j.jchf.2023.08.008
• 发表时间: 2023
• 期刊: JACC. Heart failure
• 作者: Koczo,Agnes;Rao,Anjali;Starling,RandallC;Cooper,LeslieT;Dec,GWilliam;Alexis,JeffreyD;Gorcsan,John;McTiernan,Charles;McNamara,DennisM
• 通讯作者: McNamara,DennisM

Association of activin A and postpartum blood pressure in peripartum cardiomyopathy.

围产期心肌病中激活素 A 与产后血压的关联。

• DOI: 10.1016/j.preghy.2023.10.002
• 发表时间: 2023
• 期刊: Pregnancy hypertension
• 作者: Koczo,Agnes;Marino,Amy;Polsinelli,VincenzoB;Alharethi,Rami;Damp,Julie;Ewald,Gregory;Givertz,MichaelM;Boehmer,John;Hanley-Yanez,Karen;Rana,Sarosh;Roh,Jason;McNamara,DennisM;IPACInvestigators
• 通讯作者: IPACInvestigators

Smooth muscle cells in atherosclerosis: clones but not carbon copies.

• DOI: 10.1016/j.jvssci.2021.02.002
• 发表时间: 2021
• 期刊: JVS-vascular science
• 作者: Espinosa-Diez C;Mandi V;Du M;Liu M;Gomez D
• 通讯作者: Gomez D