Effect of Waterpipe Tobacco Ingredients on Human Puffing, Exposures and Appeal

水烟烟草成分对人类吸食、暴露和吸引力的影响

• 批准号: 9330129
• 负责人: Stephanie S Buehler
• 金额: $ 49.68万
• 依托单位: BATTELLE CENTERS/PUB HLTH RES & EVALUATN
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-15 至 2020-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9330129
• 关键词: Acetaldehyde; Acrolein; Address; Affect; Analytical Chemistry; Apple; Artificial Sweeteners; Behavior; Breathing; Candy; Carcinogens; Chemicals; Cigarette; Data; Development; Electronic cigarette; Exposure to; Flavoring; Food; Form Perception; Formaldehyde; Fruit; Glycerol; Human; Individual; Ingestion; Label; Laboratories; Link; Liquid substance; Mainstreaming; Masks; Measures; Nicotine; Participant; Particle Size; Perception; Preparation; Prevalence; Propylene Glycols; Regimen; Reporting; Research; Sensory; Smoke; Smoker; Smoking; Standardization; Sucrose; Taste Perception; Time; Tobacco; Tobacco smoke; Tobacco smoking; Tobacco use; Toxic effect; Toxicant exposure; Weight; Work; Youth; cigarette smoking; cigarette smoking; design; evidence base; experience; hedonic; hookah; human study; instrument; interest; particle; particle exposure; psychosocial; sound; sugar; toxicant; university student; young adult

Project Summary Waterpipe (WP) tobacco smoking has surpassed cigarette smoking and now rivals the electronic cigarette as the most popular tobacco product class in the US among youth. This may be due to the availability of sweet, fruit- and candy-flavored tobaccos that make inhaling tobacco smoke more appealing. It is not clear what is most important in terms of increasing appeal: the smoker's perception of sweetness, or flavor, or both. WP tobacco is unique because of the amounts and identities of its additives and the way that it is smoked. The flavorings and high levels of sweet humectants produce harmful and potentially harmful constituents in the smoke, and are thought to contribute to the direct and indirect harm experienced by users. To define the effects of specific chemical content with respect to sweet perception and likability among users, WP tobacco that differs only in the variables of interest must be used. There is no set of commercially available tobacco brands for which this is true, and thus we propose to manipulate commercial products to properly isolate the important variables. There is an existing data gap surrounding the influence of WP tobacco additives, i.e., sweet humectants and flavorings, on the addictiveness, toxicity, flavor perceptions and appeal of WP smoking. The proposed study uses a crossover human trial, a manipulated WP tobacco prodcut, a validated research grade waterpipe and cutting edge analytical chemistry and psychosocial instruments to systematically investigate the effects of sweet humectant concentration and flavorings on the appeal, puffing behavior, and toxicity of WP tobacco smoking. The purpose of the proposed study is to acquire sound scientific data to inform the development of possible regulatory actions such as identifying and establishing evidenced-based product standards, or maximum thresholds of additives in WP tobacco that must not be exceeded in order for the product to be sold and distributed in the US. This study will address RFA-OD-15-005 questions 3 and 4 by quantifying the impact of WP tobacco additives, such as humectants and flavorants, on human puffing behaviors and HPHC levels in mainstream WP tobacco smoke to address these important data gaps.

项目摘要 水烟（WP）烟草吸烟已超过吸烟，现在与电子烟相匹配 美国最受欢迎的烟草产品课程。这可能是由于甜蜜的可用性 水果和糖果味的烟草使吸入烟草烟雾更具吸引力。目前尚不清楚什么是 在越来越吸引人方面最重要的是：吸烟者对甜味或风味或两者兼而有之。 WP 烟草之所以独一无二，是因为其添加剂的数量和身份以及吸烟的方式。这 调味剂和高水平的甜湿度在 烟雾，被认为会导致用户遇到的直接和间接伤害。定义 特定化学含量在用户中甜蜜的感知和可爱性方面的影响，WP烟草 必须使用仅在感兴趣的变量中的不同。没有一套可商购的烟草 这是真的的品牌，因此我们建议操纵商业产品以正确隔离 重要变量。 WP烟草添加剂的影响，即 甜蜜的湿度和调味剂，关于下瘾性，毒性，风味感和WP吸烟的吸引力。 拟议的研究使用了一项跨界人类试验，一种操纵的WP烟草产品，这是一项经过验证的研究 级水管和尖端分析化学和心理社会仪器系统地 研究甜湿度浓度和调味剂对吸引力，浮肿行为的影响以及 WP烟草吸烟的毒性。拟议的研究的目的是获取可靠的科学数据以告知 开发可能的监管行动，例如识别和建立基于证据的产品 WP烟草中不得超过的标准或最大添加剂阈值 产品将在美国出售和分发。这项研究将解决RFA-OD-15-005问题3和4 量化WP烟草添加剂（例如保湿剂和调味剂）对人浮肿的影响 主流WP烟草烟雾中的行为和HPHC水平以解决这些重要的数据差​​距。