Community-based Participatory Design of an HPV rapid diagnostic test for cervical cancer screening in South Florida

南佛罗里达州基于社区的宫颈癌筛查 HPV 快速诊断测试设计

• 批准号: 9805616
• 负责人: Natalia Maria Rodriguez
• 金额: $ 16.9万
• 依托单位: PURDUE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-20 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9805616
• 关键词: Active Learning; Address; Adoption; Age-Years; American; Automobile Driving; Award; Bedside Testings; Biomedical Engineering; Cancer Detection; Cancer Diagnostics; Caring; Cause of Death; Centers for Disease Control and Prevention (U.S.); Cervical; Cervical Cancer Screening; Cessation of life; Clinical Sciences; Clinical Trials; Communities; Community Health; Community Health Aides; Comprehensive Cancer Center; Country; Cytology; DNA; Data; Detection; Development; Development Plans; Diagnostic tests; Doctor of Philosophy; Effectiveness; Ensure; Equipment; Excision; Face; Feedback; Florida; Future; Geography; Goals; HPV-High Risk; Health; Health Personnel; Health Policy; Health Sciences; Health Technology; Health system; Home environment; Hour; Human; Human Papilloma Virus Vaccination; Human Papillomavirus; Human Resources; Incidence; Income; Infrastructure; Institutes; Intervention; Knowledge; Laboratories; Language; Lead; Legal patent; Lesion; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Mentors; Mentorship; Methods; Mind; Molecular Diagnostic Testing; Nanotechnology; Outcome; Population; Poverty Areas; Premalignant; Process; Public Health; Qualitative Methods; Qualitative Research; Randomized; Research; Research Assistant; Research Design; Research Methodology; Research Personnel; Research Training; Resources; Running; Sampling; Social support; Structure; Technology; Testing; Time; Training; Training Activity; Translational Research; Translations; Underserved Population; United States; Universities; Woman; Work; base; cancer health disparity; career; career development; community based participatory research; control trial; design; equipment training; follow-up; global health; health literacy; high risk population; human model; implementation science; improved; innovation; innovative technologies; medical schools; medically underserved; molecular diagnostics; mortality; multidisciplinary; off-patent; point of care; portability; pre-clinical; professor; programs; prototype; research and development; screening; screening program; skills; social; social exclusion; success; technology development; tool; translational cancer research; uptake; validation studies

PROJECT SUMMARY: Natalia Rodriguez, PhD, MPH, Research Assistant Professor at the University of Miami (UM), is a biomedical engineer and global health researcher whose overarching career goal is to develop and improve upon mechanisms for successful uptake and systemic adoption of innovative cancer detection technologies through human-centered and community-based participatory design, in order to empower community health workforces, strengthen health systems, and improve health outcomes at the population level. There is a pressing and unmet need for an inexpensive HPV rapid diagnostic test (RDT) that is designed with the end-user in mind and amenable to rapid systemic adoption in any given context. The research Dr. Rodriguez proposes entitled, Community-based Participatory Design of a Human Papillomavirus (HPV) Rapid Diagnostic Test for Cervical Cancer Screening in South Florida, combines community-based participatory research (CBPR) methodology and human-centered design with health technology development to inform the design and translation of a rapid, point-of-care HPV molecular diagnostic test for community use in cervical cancer screening. Dr. Rodriguez‘s previous work in technology development, specifically a molecular diagnostic platform for point-of-care testing of HPV, in combination with her current work in health systems and community health worker (CHW) training have prepared her to conduct the proposed research. Dr. Rodriguez proposes training activities that include didactic and experiential learning on: 1) Qualitative research study design and CBPR methodology; 2) Stakeholder engagement and human-centered design principles; 3) Implementation science and translational research; 4) Designing and conducting randomized control trials. The proposed career development plan will build upon her previous training to enhance her trajectory towards an independent investigator in public health and translational sciences. An outstanding multidisciplinary mentorship team will guide Dr. Rodriguez through the proposed research and training goals: Dr. Kobetz has expertise in CBPR, cancer disparities research and clinical trials, Dr. Daunert in molecular diagnostic development, and Dr. Knaul in health systems and policy, stakeholder engagement, and CHW training. The proposed research and career development plan utilize the breadth of resources at UM including the Clinical and Translational Science Institute, the Sylvester Comprehensive Cancer Center, and the laboratory and prototyping facilities and equipment of the Biomedical Nanotechnology Institute at UM (BioNIUM) and UM’s Miller School of Medicine. The strong mentors, collaborators, and resources at UM ensure the success of the proposed research. This award will provide Dr. Rodriguez with the training and preliminary data needed to be successful in a future R01 study to validate the HPV RDT and will facilitate her development into an independent investigator and leader in translational research on cancer diagnostic tools for medically-underserved communities.

项目摘要： 纳塔利亚·罗德里格斯（Natalia Rodriguez）博士，MPH，迈阿密大学（UM）的研究助理教授，是生物医学 工程师和全球卫生研究人员的总体职业目标是发展和改进 通过成功吸收和系统地采用创新癌症检测技术的机制 以人为中心的社区参与设计，以赋予社区卫生劳动力的能力， 加强卫生系统，并改善人口水平的健康状况。有一个紧迫的 需要廉价的HPV快速诊断测试（RDT），该测试是考虑到最终用户和最终用户的设计 在任何给定的情况下都可以快速采用全身采用。 Rodriguez博士的研究标题为“ 人类乳头瘤病毒（HPV）的基于社区的参与式设计快速诊断测试 南佛罗里达州的癌症筛查，基于社区的参与研究（CBPR）方法论 以及以人为中心的设计，具有卫生技术开发，以告知快速，快速的设计和翻译 护理点HPV分子诊断测试用于宫颈癌筛查中的社区使用。 罗德里格斯（Rodriguez）博士以前的技术开发工作，特别是分子诊断平台 为了进行HPV的护理点测试，结合了她目前在卫生系统和社区卫生方面的工作 工人（CHW）培训使她准备进行拟议的研究。罗德里格斯博士的提案培训 包括教学和经验丰富的学习的活动：1）定性研究设计和CBPR 方法论； 2）利益相关者的参与和以人为本的设计原则； 3）实施科学 并翻译研究； 4）设计和进行随机对照试验。拟议的职业 发展计划将以她先前的培训为基础，以增强她对独立的轨迹 公共卫生和翻译科学的研究者。 一个杰出的多学科心态团队将通过拟议的研究指导罗德里格斯博士 和培训目标：Kobetz博士在CBPR，癌症差异研究和临床试验方面具有专业知识，Daunert博士 在分子诊断开发方面以及卫生系统与政策，利益相关者参与的Knaul博士以及 CHW培训。拟议的研究和职业发展计划利用了UM的资源广度 包括临床和转化科学研究所，西尔维斯特综合癌症中心以及 UM（Bionium）生物医学纳米技术研究所的实验室和原型设施和设备 和UM米勒医学院。 强大的导师，合作者和UM的资源确保了拟议研究的成功。 该奖项将为Rodriguez博士提供未来成功的培训和初步数据 R01研究以验证HPV RDT，并将促进她的发展成独立研究者，并 针对医疗服务的癌症诊断工具的翻译研究领导者。