National Consortium on Alcohol and NeuroDevelopment in Adolescence (N-CANDA): SRI

国家青少年酒精与神经发育联盟 (N-CANDA)：SRI

• 批准号: 9069370
• 负责人: Fiona C Baker
• 金额: $ 90.52万
• 依托单位: SRI INTERNATIONAL
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-05 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9069370
• 关键词: Abstinence; Address; Adolescence; Adolescent; Adult; Advanced Development; Adverse effects; Affect; Affective; Age; Alcohol consumption; Alcohol or Other Drugs use; Alcoholic Intoxication; Alcoholism; Alcohols; Anatomy; Area; Behavioral; Brain; Brain imaging; California; Characteristics; Childhood; Clinical assessments; Cognitive; Communities; DNA; Data; Data Analyses; Development; Diagnostic; Diffusion Magnetic Resonance Imaging; Dose; Drug usage; Electroencephalography; Family history of; Functional Magnetic Resonance Imaging; Future; Goals; Heavy Drinking; Human; Imaging Techniques; International; Laboratories; Longitudinal Studies; Magnetic Resonance Imaging; Measures; Mediating; Mental Health; Neurobiology; Neurocognitive; Neuropsychological Tests; Outcome; Pattern; Population; Prevention; Protocols documentation; Psychopathology; Recruitment Activity; Regulation; Reporting; Research; Resolution; Rest; Rewards; Risk; Risk Factors; Role; Sampling; Site; Sleep; Sleep Stages; Structure; Substance Use Disorder; System; Teenagers; Universities; Visit; adolescent alcohol; adolescent brain development; alcohol abstinence; alcohol and other drug; alcohol consequences; alcohol effect; alcohol exposure; alcohol involvement; alcohol use disorder; base; cognitive performance; disorder risk; drinking; follow-up; genetic analysis; heavy drinking during adolescence; high risk; longitudinal design; medical specialties; neurodevelopment; neuroimaging; neuropsychological; novel; psychobiologic; psychologic; relating to nervous system; response; sex; symptomatology; twelfth grade; underage drinking; white matter; young adult

DESCRIPTION (provided by applicant): In response to RFA-AA-12-006, this application proposes the SRI International Research Component of the National Consortium on Alcohol and Neurodevelopment in Adolescence (N-CANDA) to determine the effects of alcohol use on the developing adolescent brain. Recruited at ages 12 through 21, a high risk enhanced community sample of 170 SRI subjects (N=680 from all sites) will complete a baseline assessment and undergo three annual follow-up assessments in an accelerated longitudinal design. At each visit, a multimodal magnetic resonance imaging (MRI) protocol, comprehensive neuropsychological battery, and assessments of alcohol and other substance use and related problems, mental health symptomatology, and substance use disorder risk factors will be measured. Brain imaging includes state-of-the-art high resolution structural MRI (sMRI), diffusion tensor imaging (DTI), and resting state MRI (rsMRI). The examination of alcohol consequences will focus on structural and functional maturation of brain areas that are actively developing during adolescence, involved in psychological regulation, responsive to rewards, and thought to be vulnerable to untoward alcohol effects. In addition, the SRI Research Component will collaborate on two additional studies. We will collaborate with Pittsburgh in a laboratory sleep study to examine the effects of adolescent heavy drinking on developmental trajectories of sleep EEG, a novel and sensitive marker of functional brain integrity. We will also collaborate with UCSD to study the effects of adolescent heavy drinking on default mode network integrity, and the extent to which this mediates cognitive performance, using functional connectivity analysis of data acquired in an fMRI protocol conducted during a Stroop Match-to-Sample Task. Studied in the context of risks and baseline brain characteristics, we will determine both the effects of alcohol exposure on the developmental trajectory of the adolescent human brain, and identify preexisting psychobiological vulnerabilities that may put an adolescent at heightened risk for an alcohol use disorder.

描述（由申请人提供）：响应RFA-AA-12-006，本申请提出了国家酒精和神经发育联盟的SRI国际研究成分（N-CANDA），以确定酒精使用对发展青少年大脑的影响。在12至21岁时招募，高风险增强了170名SRI受试者的社区样本（来自所有站点的n = 680个）将完成基线评估，并在加速的纵向设计中进行三年的年度随访评估。每次访问时，将测量多模式磁共振成像（MRI）方案，全面的神经心理电池以及对酒精和其他药物使用以及相关问题的评估，心理健康症状和使用物质使用障碍风险因素。大脑成像包括最先进的高分辨率结构MRI（SMRI），扩散张量成像（DTI）和静止状态MRI（RSMRI）。对酒精后果的检查将集中于在青春期积极发展的大脑区域的结构和功能成熟，参与心理调节，对奖励的反应，并被认为容易受到不受欢迎的酒精影响的影响。此外，SRI研究组件将在另外两项研究中进行合作。我们将与匹兹堡合作进行实验室睡眠研究，以研究青少年饮酒对功能性脑完整性的新颖和敏感标志的睡眠轨迹的影响。我们也会 与UCSD合作研究了青少年重饮酒对默认模式网络完整性的影响，以及在Stroop匹配到样本任务中进行的fMRI协议中获得的功能连通性分析，该数据介导了认知性能的程度。在风险和基线大脑特征的背景下进行了研究，我们将既确定酒精暴露对青春期人脑发育轨迹的影响，又确定已经存在的精神病学脆弱性，这些脆弱性可能会使青少年处于对酒精使用障碍的危险中。