Biofeedback of activity in the orbitofrontal cortex for OCD

强迫症患者眶额皮质活动的生物反馈

基本信息

批准号：
9263016
负责人：
Michelle Hampson
金额：
$ 49.75万
依托单位：
YALE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-09-04 至 2019-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9263016
关键词：
Affect Area Arousal Biofeedback Body Image Brain Brain imaging Brain region Clinical Clinical Treatment Clinical assessments Cognitive Data Disease Disease remission Feedback Functional Magnetic Resonance Imaging Hyperactive behavior Image Individual Intervention Learning Measures Mental disorders Metabolism Methodology Methods Monitor Morbidity - disease rate Neurons Obsessive compulsive behavior Obsessive-Compulsive Disorder Patients Pattern Pilot Projects Population Process Protocols documentation Reporting Research Research Project Grants Rest Risk Scanning Schedule Severities Signal Transduction Symptoms Techniques Therapeutic Therapeutic Human Experimentation Time Training Work anxiety symptoms base experimental study improved insight interest neuropsychiatric disorder neuropsychiatry neuroregulation novel therapeutic intervention public health relevance success symptomatic improvement symptomatology tool

项目摘要

DESCRIPTION (provided by applicant): Biofeedback of real-time functional magnetic resonance imaging (rt-fMRI) data is a new technique in which the activity in a specific region of a subject's brain is provided as a feedback signal to the subject. The subject can experiment with different cognitive strategies to identify those that are effective in influencing brain activty in the region of interest. By practicing those strategies and monitoring their success, subjects can train themselves to control the target brain region. The proposed research project applies this technique to obsessive-compulsive disorder (OCD). More specifically, the project examines whether biofeedback of rt-fMRI data can enable individuals with OCD to develop control over activity in a region of their orbitofrontal cortex involved in symptom anxiety and thereby reduce their obsessive-compulsive symptoms. If so, this new technique may yield a low-risk, non-invasive clinical intervention for OCD. In addition, patterns of resting state functional connectivty between brain areas will be examined before and after biofeedback to determine how intrinsic brain dynamics are altered by the intervention, and how those alterations relate to changes in clinical symptoms. This will inform our understanding of the network dynamics underlying obsessive-compulsive symptoms. Although this research project is focused on developing a protocol specifically for treating and studying OCD, the methodology has great promise as both a treatment intervention and a research tool for a broad range of neuropsychiatric disorders.

描述（由申请人提供）：实时功能磁共振成像（rt-fMRI）数据的生物反馈是一种新技术，其中将受试者大脑特定区域的活动作为反馈信号提供给受试者。受试者可以尝试不同的认知策略，以确定那些能够有效影响感兴趣区域的大脑活动的策略。通过练习这些策略并监控其成功情况，受试者可以训练自己控制目标大脑区域。拟议的研究项目将该技术应用于强迫症（OCD）。更具体地说，该项目研究了 rt-fMRI 数据的生物反馈是否可以使强迫症患者能够控制与症状焦虑有关的眶额皮层区域的活动，从而减轻他们的强迫症状。如果是这样，这项新技术可能会为强迫症提供低风险、非侵入性的临床干预。此外，将在生物反馈之前和之后检查大脑区域之间的静息状态功能连接模式，以确定干预如何改变内在的大脑动力学，以及这些改变如何与临床症状的变化相关。这将有助于我们理解强迫症状背后的网络动态。尽管该研究项目的重点是开发专门用于治疗和研究强迫症的方案，但该方法作为广泛的神经精神疾病的治疗干预和研究工具具有巨大的前景。