CENTRAL SYMPATHETIC REGULATION OF THERMOGENESIS IN FEVER

发烧时中枢交感神经对产热的调节

• 批准号: 8173281
• 负责人: SHAUN F MORRISON
• 金额: $ 12.37万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173281
• 关键词: Affect; Amphetamine Abuse; Anesthesia procedures; Body Temperature; Computer Retrieval of Information on Scientific Projects Database; Energy Metabolism; Fever; Funding; Grant; Hot flushes; Hypothalamic structure; Institution; Life; Malignant Neoplasms; Mediating; Meningitis; Menopause; Neurons; Operative Surgical Procedures; Pharmaceutical Preparations; Preoptic Areas; Pyrogens; Regulation; Research; Research Personnel; Resources; Role; Sepsis; Septic Toxemia; Serotonin; Source; Spinal; Therapeutic; Thermogenesis; United States National Institutes of Health; base; clinically significant; combat; induced hypothermia; neuromechanism; paraventricular nucleus; prostate surgery

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Understanding of the central neural mechanisms mediating fever and cold defense will be relevant for developing therapeutic approaches to combat life-threatening excessive fevers (as during sepsis, toxemia, meningitis, some cancers) and to the management of the effects of thermal dysregulation that occurs during such clinically significant conditions as the abuse of amphetamine-based drugs, the hot flashes accompanying menopause and prostate surgery or the hypothermia induced during surgical anesthesia. The aims of this project are to elucidate the CNS circuits that regulate body temperature and how they are affected by pyrogens. Recent findings include the identification of distinct projections from the fever-inhibited neurons in the preoptic area to the BAT sympathoexcitatory regions of the dorsomedial hypothalamus and to the raphe pallidus, the demonstration that the principal effect of neuronal activation in the paraventricular hypothalamic nucleus is an inhibition of BAT thermogenesis and the elucidation of a prominent disinhibitory role for spinal serotonin release in the cooling-evoked increase in BAT thermogenesis and energy expenditure.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 了解介导发烧和寒冷防御的中枢神经机制将有助于开发治疗方法来对抗危及生命的过度发烧（如脓毒症、毒血症、脑膜炎和某些癌症期间），并有助于管理发热期间发生的热失调的影响。诸如滥用苯丙胺类药物、绝经期和前列腺手术引起的潮热或手术麻醉期间引起的体温过低等具有临床意义的病症。该项目的目的是阐明调节体温的中枢神经系统回路以及它们如何受到热原的影响。 最近的发现包括识别出从视前区发热抑制神经元到下丘脑背内侧 BAT 交感兴奋区和中缝苍白的不同投射，证明下丘脑室旁核神经元激活的主要作用是抑制BAT 生热作用的研究以及脊髓血清素释放在冷却引起的 BAT 增加中的显着去抑制作用的阐明生热作用和能量消耗。