Center for Natural Product Technologies at UIC (CeNAPT)

UIC 天然产物技术中心 (CeNAPT)

• 批准号: 9298580
• 负责人: Guido F Pauli
• 金额: $ 26.09万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9298580
• 关键词: Address; Advisory Committees; Architecture; Area; Awareness; Beds; Biological; Biological Assay; Chemicals; Chicago; Clinical Research; Collaborations; Communities; Complex; Congresses; Consensus; Consultations; Data; Detection; Development; Documentation; Drug Kinetics; Environment; Extramural Activities; Fingerprint; Funding; Goals; Health; Illinois; Institutes; Investigation; Knowledge; Lead; Leadership; Letters; Magnetic Bead Technology; Mass Spectrum Analysis; Metals; Methodology; Methods; Molecular Chaperones; National Center for Complementary and Alternative Medicine; Natural Products; Nuclear Magnetic Resonance; Office of Administrative Management; Outcome; Outcomes Research; Output; Pharmacognosy; Process; Reporting; Reproducibility; Research; Research Methodology; Research Personnel; Research Project Grants; Resources; Roentgen Rays; Scientist; Sensitivity and Specificity; Spectrum Analysis; Structure; TNFRSF5 gene; Targeted Research; Technology; Testing; Training; United States National Institutes of Health; Universities; Work; X ray diffraction analysis; X-Ray Diffraction; bioactive natural products; dietary supplements; high throughput technology; holistic approach; innovation; innovative technologies; interdisciplinary collaboration; interest; knowledge base; metabolomics; multidisciplinary; online resource; program dissemination; programs; public health relevance; research and development; response; scaffold; screening; synergism

 DESCRIPTION (provided by applicant): According to RFA-AT-14-006, the greater objective of a Center for Advancing Natural Products Innovation and Technology (CANPIT) is to develop, consolidate, and disseminate technologies in order to overcome methodological obstacles in natural products (NP) research, and to establish synergistic interaction between the CANPIT, external experts, and collaborating leading NP investigators. Addressing this demand, the proposed UIC CANPIT integrates three multidisciplinary Technology Research & Development (TR&D) Projects operated by an investigator team with a strong record of collaboration, innovation, and excellence in NP research. The UIC CANPIT will develop, and actively share, cutting edge bioanalytical methodologies that address important biomedical questions and advance the holistic approach to NP agents and their metabolomic complexity. The methodological improvements will address persistent needs in translational NP research: targeted and reproducible separation (TR&D Project 1), universal purity analysis, advanced structure de-replication and determination (TR&D Project 2), as well as targeted high-sensitivity detection and quantification of NPs and their pharmacokinetic metabolites (TR&D Project 3). The bioanalytical focus of the UIC CANPIT matches the majority (6 of 8) of the "Specific Areas of Research Interest" identified in the RFA. Moreover, this focus reflects the wealth of preliminary data and the availability of numerous innovative NP technologies that originate from the UIC team and are ready for adaptation, collaboration, and dissemination. Accordingly, the Projects 1/2/3 have both hypothesis- and sharing-driven aims that seek to develop, consolidate, and adapt cutting edge NP methodologies. Plans for sharing mechanisms ("adapt- and/or develop-to-share") feature the status of the CANPIT technology and proposals for collaborative research with nine outside Technology Demonstration Projects (TDPs) are presented. In addition to coordinating the CANPIT-TDP interactions, the objective of the Coordination & Dissemination (C&D) Project is to harmonize the research output of the UIC CANPIT, mine bioanalytical NP knowledge, produce Good Research Practices (GRPs) documentation for NPs, and promote the coherence of the CANPIT outcomes. An Administrative & Management (A&M) Core will manage the center's meeting and reporting functions and coordinate the intra- and extramural resources and relationships. The UIC CANPIT will receive substantial institutional and outside support as documented in 20 support letters. Working closely with the assigned NCCAM scientist and the External Advisory Committee, the PI/PD and his team seek to achieve the ultimate objective of establishing leadership in NP research methodology through bioanalytical innovation and active sharing in order to overcome the methodological hurdles currently faced by the natural products community.

 描述（由申请人提供）：根据 RFA-AT-14-006，推进天然产品创新和技术中心 (CANTIT) 的更大目标是开发、巩固和传播技术，以克服自然产品创新和技术方面的方法障碍。为了满足这一需求，UIC CANPIT 整合了三种多学科技术。研究与开发 (TR&D) 项目由在 NP 研究方面拥有良好合作、创新和卓越记录的研究团队运营，UIC CANPIT 将开发并积极分享尖端的生物分析方法，以解决重要的生物医学问题并推进整体研究。方法学的改进将满足转化 NP 研究的持续需求：有针对性和可重复的分离（TR&D 项目 1）、通用纯度分析、先进的结构去复制和测定。 （TR&D 项目 2），以及 NP 及其药代动力学代谢物的靶向高灵敏度检测和定量（TR&D 项目 3） UIC CANPIT 的生物分析重点与大多数“特定研究领域”（8 个中的 6 个）相匹配。 RFA 中确定了“兴趣”。此外，这种关注反映了丰富的初步数据和众多创新 NP 技术的可用性，这些技术源自 UIC 团队，并已准备好适应、协作和因此，项目 1/2/3 具有假设驱动和共享驱动的目标，旨在开发、巩固和调整最先进的 NP 方法学共享机制（“调整和/或开发以共享”）。 ”) 介绍了 CANPIT 技术的现状，并提出了与九个外部技术示范项目 (TDP) 进行合作研究的建议。除了协调 CANPIT-TDP 互动之外，协调和传播 (C&D) 项目旨在协调 UIC CANPIT 的研究成果，挖掘生物分析 NP 知识，为 NP 制作良好研究实践 (GRP) 文件，并促进 CANPIT 成果的一致性。管理中心的会议和报告职能并协调校内和校外资源及关系 UIC CANPIT 将获得大量机构和外部支持，如 20 支持中所述。 PI/PD 及其团队与指定的 NCCAM 科学家和外部咨询委员会密切合作，力求通过生物分析创新和积极共享来实现建立 NP 研究方法领导地位的最终目标，以克服目前面临的方法障碍。由天然产品界。