Center for Natural Product Technologies at UIC (CeNAPT)

UIC 天然产物技术中心 (CeNAPT)

• 批准号: 9298580
• 负责人: Guido F Pauli
• 金额: $ 26.09万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9298580
• 关键词: Address; Advisory Committees; Architecture; Area; Awareness; Beds; Biological; Biological Assay; Chemicals; Chicago; Clinical Research; Collaborations; Communities; Complex; Congresses; Consensus; Consultations; Data; Detection; Development; Documentation; Drug Kinetics; Environment; Extramural Activities; Fingerprint; Funding; Goals; Health; Illinois; Institutes; Investigation; Knowledge; Lead; Leadership; Letters; Magnetic Bead Technology; Mass Spectrum Analysis; Metals; Methodology; Methods; Molecular Chaperones; National Center for Complementary and Alternative Medicine; Natural Products; Nuclear Magnetic Resonance; Office of Administrative Management; Outcome; Outcomes Research; Output; Pharmacognosy; Process; Reporting; Reproducibility; Research; Research Methodology; Research Personnel; Research Project Grants; Resources; Roentgen Rays; Scientist; Sensitivity and Specificity; Spectrum Analysis; Structure; TNFRSF5 gene; Targeted Research; Technology; Testing; Training; United States National Institutes of Health; Universities; Work; X ray diffraction analysis; X-Ray Diffraction; bioactive natural products; dietary supplements; high throughput technology; holistic approach; innovation; innovative technologies; interdisciplinary collaboration; interest; knowledge base; metabolomics; multidisciplinary; online resource; program dissemination; programs; public health relevance; research and development; response; scaffold; screening; synergism

 DESCRIPTION (provided by applicant): According to RFA-AT-14-006, the greater objective of a Center for Advancing Natural Products Innovation and Technology (CANPIT) is to develop, consolidate, and disseminate technologies in order to overcome methodological obstacles in natural products (NP) research, and to establish synergistic interaction between the CANPIT, external experts, and collaborating leading NP investigators. Addressing this demand, the proposed UIC CANPIT integrates three multidisciplinary Technology Research & Development (TR&D) Projects operated by an investigator team with a strong record of collaboration, innovation, and excellence in NP research. The UIC CANPIT will develop, and actively share, cutting edge bioanalytical methodologies that address important biomedical questions and advance the holistic approach to NP agents and their metabolomic complexity. The methodological improvements will address persistent needs in translational NP research: targeted and reproducible separation (TR&D Project 1), universal purity analysis, advanced structure de-replication and determination (TR&D Project 2), as well as targeted high-sensitivity detection and quantification of NPs and their pharmacokinetic metabolites (TR&D Project 3). The bioanalytical focus of the UIC CANPIT matches the majority (6 of 8) of the "Specific Areas of Research Interest" identified in the RFA. Moreover, this focus reflects the wealth of preliminary data and the availability of numerous innovative NP technologies that originate from the UIC team and are ready for adaptation, collaboration, and dissemination. Accordingly, the Projects 1/2/3 have both hypothesis- and sharing-driven aims that seek to develop, consolidate, and adapt cutting edge NP methodologies. Plans for sharing mechanisms ("adapt- and/or develop-to-share") feature the status of the CANPIT technology and proposals for collaborative research with nine outside Technology Demonstration Projects (TDPs) are presented. In addition to coordinating the CANPIT-TDP interactions, the objective of the Coordination & Dissemination (C&D) Project is to harmonize the research output of the UIC CANPIT, mine bioanalytical NP knowledge, produce Good Research Practices (GRPs) documentation for NPs, and promote the coherence of the CANPIT outcomes. An Administrative & Management (A&M) Core will manage the center's meeting and reporting functions and coordinate the intra- and extramural resources and relationships. The UIC CANPIT will receive substantial institutional and outside support as documented in 20 support letters. Working closely with the assigned NCCAM scientist and the External Advisory Committee, the PI/PD and his team seek to achieve the ultimate objective of establishing leadership in NP research methodology through bioanalytical innovation and active sharing in order to overcome the methodological hurdles currently faced by the natural products community.

 描述（由适用提供）：根据RFA-AT-14-006，推进天然产品创新和技术中心的更大目标是开发，巩固和传播技术，以克服自然产品的方法论障碍（NP）研究，并在CANPIT，外部专业人士和合作的领导者之间建立协同互动。在满足这一需求的情况下，拟议的UIC CANPIT整合了由研究人员团队运营的三个多学科技术研发（TR＆D）项目，其协作，创新和NP研究方面的卓越表现有很强的记录。 UIC CANPIT将开发并积极共享最先进的生物分析方法，这些方法可以解决重要的生物医学问题，并推进NP剂及其代谢组复杂性的整体方法。方法学的改进将解决转化NP研究中的持续需求：针对性和可再现的分离（TR＆D项目1），通用纯度分析，先进的结构去复制和确定（TR＆D项目2），以及靶向的NPS及其NPS及其药代动力学的高度敏感性检测和量化（TR＆D项目3）。 UIC的生物分析重点与RFA中确定的“特定研究领域”的大多数（8个）相匹配。此外，这种重点反映了初步数据的财富以及源自UIC团队的众多创新NP技术的可用性，并准备进行适应，协作和传播。根据1/2/3的项目，既有假设 - 和共享驱动的目的，旨在开发，巩固和适应尖端NP NP方法。介绍了共享机制的计划（“适应和/或开发 - 共享”），介绍了CANPIT技术的状态以及与九个外部技术演示项目（TDP）的合作研究的建议。除了协调CANPIT-TDP相互作用外，协调与传播（C＆D）项目的目的是协调UIC CANPIT的研究成果，地雷生物分析NP知识，为NPS提供了良好的研究实践（GRPS）文档，并促进了鸡蛋的连贯性。行政与管理（A＆M）核心将管理中心的会议和报告功能，并协调壁外资源和关系。 UIC CANPIT将在20封支持信中记录的大量机构和外部支持。 PI/PD及其团队与指定的NCCAM科学家和外部咨询委员会紧密合作，寻求通过生物分析创新和积极共享在NP研究方法中建立领导力的最终目标，以克服自然产品社区目前面临的方法论障碍。