Training Program in Molecular, Cell, and Developmental Biology

分子、细胞和发育生物学培训项目

基本信息

批准号：
9522000
负责人：
Susan Strome
金额：
$ 28.48万
依托单位：
UNIVERSITY OF CALIFORNIA SANTA CRUZ
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
起止时间：
1999-07-01 至 2019-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9522000
关键词：
Cellular biology Developmental Biology Molecular Biology Training Programs

项目摘要

DESCRIPTION (provided by applicant): The goals of the UCSC Graduate Training Program in Molecular, Cell and Developmental Biology are to recruit highly motivated graduate students, provide them with critical thinking skills, expertise in experimental design and interpretation, an a strong framework of knowledge, while also amplifying their passion for inquiry and discovery. We strongly encourage interdisciplinary and collaborative research that crosses departmental, divisional, and even institutional boundaries. Intellectual, cultural, and socioeconomic diversity are prevalent in our graduate student population, and we constantly seek new approaches to attract and inspire students from under-represented groups. Our Training Program prepares students to pursue diverse careers in biomedical research, teaching, government, and industry. First-year trainees participate in three 6-week research rotations and in a core curriculum designed to train them in the logic of experimental analysis. Students learn how to evaluate published research, effectively argue scientific points, formulate hypotheses, design rigorous experiments, and write research manuscripts and proposals with intellectual depth. Students join a laboratory to pursue their Ph.D. thesis research in Spring of their first year. Second-year students train in the responsible conduct of research and take an oral qualifying exam. Third-year students present a full research seminar to the Training Program. Students at all stages participate in departmental seminars, research meetings, and journal clubs, and take advanced elective courses of their choosing. These broaden their training experience and promote interactions among trainees and faculty. Training culminates with a written Ph.D. dissertation and oral defense. Our Training Program includes 30 faculty from 5 departments, including the Departments of Molecular, Cell and Developmental Biology, Biomolecular Engineering, Chemistry and Biochemistry, Microbiology and Environmental Toxicology, and Physics. Participating laboratories are intermingled in 3 adjacent buildings on "science hill", which encourages interaction and collaboration. Research in the Training Program utilizes a wide variety of approaches, and is organized with interdisciplinary clusters of common interests (e.g. Cell Biology, Chromatin, Neurobiology, and RNA), thereby creating critical masses of researchers that foster mutual support and scientific creativity. Many training faculty work on systems that are directly relevant to human health, including stem cell biology, malaria, cholera, cancer biology, host-pathogen interactions, neurodegenerative diseases, and the responses of neurons to stroke and other damage. Other faculty carry out basic research that provides the foundation for understanding topics relevant to human health, including cell division, signaling, meiosis, chromatin organization, cell differentiation, and neurobiology. Our Training Grant, currently in its 14th year, supports 6 trainees. In this renewal, we are requesting support for 8 trainees. Training Grant positions will continue to be awarded to our most promising students.

描述（由申请人提供）：分子，细胞和发育生物学的UCSC研究生培训计划的目标是招募高度积极进取的研究生，为他们提供批判性思维技能，实验设计和解释方面的专业知识，一个强大的知识框架，同时也扩大了他们对询问和发现的热情。我们强烈鼓励跨学科和合作研究跨越部门，分区甚至机构界限。智力，文化和社会经济多样性在我们的研究生群体中普遍存在，我们不断寻求新的方法来吸引和激发代表不足的群体的学生。我们的培训计划使学生为从事生物医学研究，教学，政府和工业的各种职业做好准备。一年级学员参加了三个为期6周的研究轮换，并参加了旨在培训他们实验分析逻辑的核心课程。学生学习如何评估已发表的研究，有效地论证了科学观点，提出假设，设计严格的实验，并撰写具有智力深度的研究手稿和建议。学生加入实验室攻读博士学位。第一年春季的论文研究。二年级学生培训负责任的研究并参加口头符合条件考试。三年级的学生为培训计划举办了完整的研究研讨会。各个阶段的学生都参加了部门研讨会，研究会议和期刊俱乐部，并参加了他们选择的高级选修课程。这些扩大了他们的训练经验，并促进了学员和教师之间的互动。培训以书面博士学位达到高潮。论文和口头辩护。我们的培训计划包括来自5个部门的30位教职员工，包括分子，细胞和发育生物学部门，生物分子工程，化学和生物化学，微生物学和环境毒理学以及物理学。参与的实验室在“科学山”上的3座相邻建筑物中混合在一起，这鼓励了互动和协作。培训计划中的研究采用了多种方法，并以跨学科的共同利益群（例如细胞生物学，染色质，神经生物学和RNA）进行了组织，从而创造了重要的研究人员，从而促进了共同的支持和科学的创造力。许多培训教师在与人类健康直接相关的系统上的许多培训工作，包括干细胞生物学，疟疾，霍乱，癌症生物学，宿主 - 病原体相互作用，神经退行性疾病以及神经元对中风和其他损害的反应。其他教师进行基础研究，为理解与人类健康相关的主题提供了基础，包括细胞分裂，信号传导，减数分裂，染色质组织，细胞分化和神经生物学。我们目前已有14年的培训赠款支持6名受训者。在此续约中，我们要求为8名学员提供支持。培训赠款职位将继续授予我们最有前途的学生。

项目成果

期刊论文数量（65）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Genetic Models Reveal cis and trans Immune-Regulatory Activities for lincRNA-Cox2.

DOI：
10.1016/j.celrep.2018.10.027
发表时间：
2018-11-06
期刊：
Cell reports
影响因子：
8.8
作者：
Elling R;Robinson EK;Shapleigh B;Liapis SC;Covarrubias S;Katzman S;Groff AF;Jiang Z;Agarwal S;Motwani M;Chan J;Sharma S;Hennessy EJ;FitzGerald GA;McManus MT;Rinn JL;Fitzgerald KA;Carpenter S
通讯作者：
Carpenter S

Mutating two putative phosphorylation sites on ZHP-3 does not affect its localization or function during meiotic chromosome segregation.

DOI：
10.17912/micropub.biology.000354
发表时间：
2021-01-18
期刊：
microPublication biology
影响因子：
0
作者：
Russo AE;Nelson CR;Bhalla N
通讯作者：
Bhalla N

Inheritance of protection from osmotic stress.

渗透应激保护的遗传。

DOI：
10.1038/ncb3483
发表时间：
2017
期刊：
Nature cell biology
影响因子：
21.3
作者：
Kaneshiro,KiyomiR;Strome,Susan
通讯作者：
Strome,Susan

All hematopoietic cells develop from hematopoietic stem cells through Flk2/Flt3-positive progenitor cells.

DOI：
10.1016/j.stem.2011.04.021
发表时间：
2011-07-08
期刊：
CELL STEM CELL
影响因子：
23.9
作者：
Boyer, Scott W.;Schroeder, Aaron V.;Smith-Berdan, Stephanie;Forsberg, E. Camilla
通讯作者：
Forsberg, E. Camilla

The draft genome of Planococcus donghaensis MPA1U2 reveals nonsporulation pathways controlled by a conserved Spo0A regulon.

东海平球菌 MPA1U2 的基因组草图揭示了由保守的 Spo0A 调节子控制的非孢子形成途径。