Cognitive Control in Anxiety: The Role of Ovarian Hormones

焦虑中的认知控制：卵巢激素的作用

• 批准号: 9249682
• 负责人: Jason Scot Moser
• 金额: $ 54.48万
• 依托单位: MICHIGAN STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-03-25 至 2021-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9249682
• 关键词: Address; Affect; Age; Animals; Anxiety; Anxiety Disorders; Behavior Control; Brain; Clinical Psychology; Collection; Communities; Comorbidity; Computers; Data; Diagnostic; Disease; Engineering; Estradiol; Female; Frequencies; Functional disorder; Glare; Goals; Healthcare; Hormones; Human; Impaired cognition; Impairment; Laboratories; Light; Longevity; Maintenance; Measurement; Measures; Menstrual cycle; Mental Health; Methods; Modeling; Monitor; Nature; Neurobiology; Neuroendocrinology; Ovarian hormone; Ovulation; Performance; Phase; Play; Progesterone; Protocols documentation; Puberty; Reporting; Research; Resources; Risk; Role; Sampling; Scientist; Sex Characteristics; Short-Term Memory; Source; Specific qualifier value; Structure; Symptoms; Techniques; Testing; Time; Translations; Woman; Women' s Health; Work; anxiety symptoms; anxious; clinical development; cognitive control; cognitive neuroscience; design; disability; health care service utilization; indexing; innovation; longitudinal design; men; neurobehavioral; neurobiological mechanism; neurophysiology; novel; pre-clinical; public health priorities; public health relevance; sex; skills; theories; tool; tool development; young adult

 DESCRIPTION (provided by applicant): The proposed project will address the nature and impact of anxiety in women by examining the interplay of anxiety, cognitive control dysfunction, and ovarian hormones (i.e., estradiol and progesterone). Despite sex differences in brain structure and function critical to cognitive control, limited works has been dedicated to directly examining how such differences might play a role in how anxiety manifests in and affects women. We will address this glaring gap in our understanding of anxiety in women by testing the novel hypothesis that estradiol "amplifies" the association between anxiety - verbal worry, in particular - and cognitive control dysfunction. The design of the study uses a community sample of young adult females assessed intensively across the menstrual cycle to directly examine the contributions of ovarian hormones to the association between worry and cognitive control dysfunction. It will leverage the power of an interdisciplinary collaborative team consisting of experts in cognitive neuroscience, neuroendocrinology, women's health, clinical psychology, and computer engineering. The proposed project will involve collecting daily measures of anxiety-related symptoms and ovarian hormones as well as neurobehavioral indices of cognitive control at four separate occasions during the menstrual cycle. The specific aims of the study are to: 1) establish the role of estradiol in the association between worry and impaired working memory, 2) confirm the role of estradiol in the association between worry and maladaptive cognitive control-related performance monitoring, and 3) delineate the role of estradiol in the interactive effect of worry and working memory on maladaptive cognitive control-related performance monitoring. The long-term promise of this research is that it will elucidate a neuroendocrinological mechanism involved in the unique nature and impact of anxiety in women. Our multi- method, mechanistic approach has the potential to pinpoint particular periods of elevated risk for anxiety- related cognitive dysfunction during the menstrual cycle and across the lifespan (e.g., puberty), as well as identify novel neurobiological treatment targets for anxiey disorders in women.

 描述（由适用提供）：拟议的项目将通过检查动画，认知控制功能障碍和卵巢激素（即雌二醇和孕酮）的相互作用来解决女性动画在女性中的性质和影响。尽管大脑结构和对认知控制至关重要的功能的性别差异，但有限的作品仍致力于直接研究这种差异如何在动画表现和影响女性中发挥作用。我们将通过测试雌二醇“放大”焦虑 - 尤其是言语忧虑和认知控制功能障碍的新颖假说来解决女性对女性动画的理解。这项研究的设计使用了在月经周期进行深入评估的年轻女性的社区样本，以直接检查卵巢骑马对忧虑和认知控制功能障碍之间关联的贡献。利用由认知神经科学，神经内分泌学，妇女健康，临床心理学和计算机工程专家组成的跨学科合作团队的力量。拟议的项目将涉及每天收集与焦虑有关的症状和卵巢骑马的测量，以及在月经周期中四个不同场合的认知控制的神经行为指数。该研究的具体目的是：1）确定雌二醇在忧虑和工作记忆受损之间的关联中的作用，2）确认雌二醇在忧虑和适应性认知控制性控制相关的性能监测之间的关联中的作用，而3）划定雌二醇在忧虑和障碍对不适当的确认性能的互动效果中的作用，并促进促进性能的性能促进性能，并促进促进性能促进。这项研究的长期承诺是，它将阐明涉及焦虑症对女性的独特性质和影响的神经内分泌机制。我们的多方法，机械方法有可能确定月经周期和整个生命周期（例如青春期）的特定时期的焦虑相关认知功能障碍的升高时期，并确定了女性焦虑症的新型神经生物学治疗靶标。