Impact of Physical Activity Routines and Dietary Intake on the Longitudinal Symptom Experience of the people living with HIV (PROSPER-HIV)

体力活动习惯和饮食摄入对艾滋病毒感染者纵向症状体验的影响 (PROSPER-HIV)

• 批准号: 9794140
• 负责人: ALLISON R WEBEL
• 金额: $ 67万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-26 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9794140
• 关键词: Accelerometer; Acquired Immunodeficiency Syndrome; Acute; Adult; Affect; Age; Aging; Alabama; Anxiety; Biological; Biology; Body mass index; Boston; Carbohydrates; Caring; Chronic Disease; Clinic; Clinical; Clinical Data; Collection; Comorbidity; Data; Data Quality; Depressed mood; Diet; Dietary Intervention; Dietary Practices; Dietary intake; Disease; Distress; Eating; Enrollment; Fatigue; Feedback; Fiber; Foundations; Frequencies; Future; Geography; Goals; Gold; HIV; Hand; Hand Strength; Health; Health Personnel; Health Promotion; Hour; Individual; Inflammation; Infrastructure; Institutes; Intake; Intervention; Investigation; Lead; Lipids; Longitudinal Studies; Massachusetts; Measures; Mediating; Mediator of activation protein; Mental Depression; Mission; Multi-Institutional Clinical Trial; National Institute of Nursing Research; Obesity; Ohio; Pain; Participant; Patient Outcomes Assessments; Patient Self-Report; Patients; Pattern; Personal Satisfaction; Pharmaceutical Preparations; Phase; Physical Fitness; Physical Performance; Physical activity; Population; Prevalence; Proteins; Quality of life; Questionnaires; Race; Regimen; Reporting; Research; Sampling; Site; Sleeplessness; Symptoms; System; Testing; Time; United States; Universities; Waist-Hip Ratio; Washington; age related; antiretroviral therapy; associated symptom; base; biobank; clinical research site; cohort; daily functioning; design; experience; improved; innovation; medical specialties; novel; nutrition; pill; programs; prospective; reduce symptoms; sex; side effect; standard measure; symptom management; symptom science; therapy adherence

Project Summary/Abstract: People living with HIV (PLHIV) experience a disproportionately high symptom burden (e.g., fatigue, insomnia, pain) with few treatment options. These symptoms are frequent, distressing, often co-occur, and have significant consequences on the health and well-being of PLHIV, yet we know almost nothing about how to effectively mitigate them. Non-pharmacological treatment options are highly desirable for symptom management among PLHIV who already experience a high pill burden from multiple comorbid diseases. Our team previously reported that physical activity and better nutrition were associated with lower symptom intensity in PLHIV; but a clearer understanding of the effects of physical activity and diet is required to determine how these approaches can reduce symptom distress in this population. Building on these data, this project proposes to examine the effect of two promising non-pharmacological strategies, Physical Activity Routines And Dietary Intake, on the longitudinal Symptom Experience of PLHIV (PARADISE-HIV). The PARADISE-HIV study is an observational, longitudinal study that will utilize the substantial infrastructure of the Centers for AIDS Research (CFAR) Network of Integrated Clinical Systems (CNICS) to examine physical activity and dietary patterns and symptom burden of 850 PLHIV over four years. This study will occur in four demographically diverse HIV clinics [Case Western Reserve University (Cleveland, Ohio), University of Alabama at Birmingham (Birmingham, Alabama), University of Washington (Seattle, Washington) and Fenway Health Institute (Boston, Massachusetts)]. PARADISE-HIV will overcome the limitations of previous studies by 1) enrolling a large, demographically and geographically diverse, clinic-based sample of PLHIV, 2) examining the relationship between physical activity, dietary intake and symptom burden over time, and 3) using prospective, gold-standard measures of physical activity (i.e., triaxial accelerometry) and dietary intake (i.e., 24-hour diet recalls). Anthropomorphic and physical fitness factors will be assessed as potential mediators of physical activity and dietary intake on symptom burden and intensity. When our aims are accomplished we will have precise, definitive, high-quality data describing the impact of physical activity and diet on symptoms in PLHIV. These data can be used clinically to provide feedback to HIV health care providers on the physical activity and dietary intake of their patients. The PARADISE-HIV study will also have a significant scientific impact and will inform the next phase of this program of research. These findings will be used to develop an individually-targeted, clinic-based intervention to improve physical activity and dietary intake that will eventually reduce symptoms among PLHIV. They will also be used to examine biological and clinical mechanisms that lead to the prevalent unremitting symptoms experienced by PLHIV. Thus, the proposed study is likely to stimulate novel research that will have a long-term impact on the health and quality of life of PLHIV.

项目摘要/摘要： 艾滋病毒感染者 (PLHIV) 经历着不成比例的高症状负担（例如疲劳、失眠、 痛），治疗选择很少。这些症状频繁发生、令人痛苦、经常同时出现，并且 对艾滋病病毒感染者的健康和福祉产生重大影响，但我们几乎不知道如何 有效缓解它们。对于症状来说，非常需要非药物治疗选择 对已经因多种共存疾病而承受较高药物负担的艾滋病毒感染者进行管理。我们的 研究小组之前报告说，体力活动和更好的营养与较低的症状有关 艾滋病病毒感染者的强度；但需要更清楚地了解体力活动和饮食的影响 确定这些方法如何减轻该人群的症状困扰。基于这些数据，这 项目建议检查两种有前途的非药物策略的效果：体力活动 日常习惯和膳食摄入量，关于艾滋病毒携带者的纵向症状体验（PARADISE-HIV）。 PARADISE-HIV 研究是一项观察性纵向研究，将利用大量数据 艾滋病研究中心 (CFAR) 综合临床系统网络 (CNICS) 的基础设施 检查四年来 850 名艾滋病病毒感染者的身体活动、饮食模式和症状负担。这项研究 将在四个人口不同的艾滋病毒诊所进行[凯斯西储大学（俄亥俄州克利夫兰）， 阿拉巴马大学伯明翰分校（阿拉巴马州伯明翰）、华盛顿大学（华盛顿州西雅图） 和芬威健康研究所（马萨诸塞州波士顿）]。 PARADISE-HIV 将克服以下限制 之前的研究通过 1) 招募了大量的、人口统计和地理上多样化的、基于临床的样本 艾滋病毒携带者，2) 检查身体活动、饮食摄入和症状负担之间的关系随时间的变化， 3) 使用前瞻性、黄金标准的身体活动测量（即三轴加速度测量）和饮食 摄入量（即 24 小时饮食回忆）。拟人化和身体健康因素将被评估为潜在的 身体活动和饮食摄入对症状负担和强度的调节因素。当我们的目标是 一旦完成，我们将获得精确、明确、高质量的数据来描述物理影响 活动和饮食对 PLHIV 症状的影响。 这些数据可用于临床，向艾滋病毒卫生保健提供者提供有关身体状况的反馈。 患者的活动和饮食摄入量。 PARADISE-HIV 研究也将具有重要的科学意义 影响并将为本研究计划的下一阶段提供信息。这些发现将用于开发 有针对性的、基于临床的干预措施，以改善身体活动和饮食摄入，最终将 减少艾滋病毒携带者的症状。它们还将用于检查生物和临床机制 导致 PLHIV 经历普遍的持续症状。因此，拟议的研究很可能 刺激对艾滋病病毒感染者的健康和生活质量产生长期影响的新颖研究。