Impact of Physical Activity Routines and Dietary Intake on the Longitudinal Symptom Experience of the people living with HIV (PROSPER-HIV)

体力活动习惯和饮食摄入对艾滋病毒感染者纵向症状体验的影响 (PROSPER-HIV)

• 批准号: 10387231
• 负责人: ALLISON R WEBEL
• 金额: $ 68.48万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-26 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10387231
• 关键词: Accelerometer; Acquired Immunodeficiency Syndrome; Acute; Adult; Affect; Age; Aging; Alabama; Anxiety; Biological; Biology; Body mass index; Boston; Carbohydrates; Caring; Chronic Disease; Clinic; Clinical; Clinical Data; Collection; Data; Depressed mood; Diet; Dietary Intervention; Dietary Practices; Dietary intake; Disease; Distress; Eating; Enrollment; Fatigue; Feedback; Fiber; Foundations; Frequencies; Future; Geography; Goals; Gold; HIV; Hand; Hand Strength; Health; Health Personnel; Health Promotion; Hour; Individual; Inflammation; Infrastructure; Institutes; Intake; Intervention; Investigation; Lead; Lipids; Longitudinal Studies; Massachusetts; Measures; Mediating; Mediator of activation protein; Mental Depression; Mission; Multi-Institutional Clinical Trial; National Institute of Nursing Research; Obesity; Ohio; Pain; Participant; Patient Outcomes Assessments; Patient Self-Report; Patients; Pattern; Personal Satisfaction; Pharmaceutical Preparations; Phase; Physical Fitness; Physical Performance; Physical activity; Population; Prevalence; Proteins; Quality of life; Questionnaires; Race; Regimen; Reporting; Research; Sampling; Site; Sleeplessness; Symptoms; System; Testing; Time; Unhealthy Diet; United States; Universities; Waist-Hip Ratio; Washington; age related; antiretroviral therapy; associated symptom; base; biobank; clinical research site; cohort; comorbidity; daily functioning; design; dietary; experience; improved; innovation; medical specialties; novel; nutrition; pill; programs; prospective; reduce symptoms; sex; side effect; standard measure; symptom management; symptom science; therapy adherence

Project Summary/Abstract: People living with HIV (PLHIV) experience a disproportionately high symptom burden (e.g., fatigue, insomnia, pain) with few treatment options. These symptoms are frequent, distressing, often co-occur, and have significant consequences on the health and well-being of PLHIV, yet we know almost nothing about how to effectively mitigate them. Non-pharmacological treatment options are highly desirable for symptom management among PLHIV who already experience a high pill burden from multiple comorbid diseases. Our team previously reported that physical activity and better nutrition were associated with lower symptom intensity in PLHIV; but a clearer understanding of the effects of physical activity and diet is required to determine how these approaches can reduce symptom distress in this population. Building on these data, this project proposes to examine the effect of two promising non-pharmacological strategies, Physical Activity Routines And Dietary Intake, on the longitudinal Symptom Experience of PLHIV (PARADISE-HIV). The PARADISE-HIV study is an observational, longitudinal study that will utilize the substantial infrastructure of the Centers for AIDS Research (CFAR) Network of Integrated Clinical Systems (CNICS) to examine physical activity and dietary patterns and symptom burden of 850 PLHIV over four years. This study will occur in four demographically diverse HIV clinics [Case Western Reserve University (Cleveland, Ohio), University of Alabama at Birmingham (Birmingham, Alabama), University of Washington (Seattle, Washington) and Fenway Health Institute (Boston, Massachusetts)]. PARADISE-HIV will overcome the limitations of previous studies by 1) enrolling a large, demographically and geographically diverse, clinic-based sample of PLHIV, 2) examining the relationship between physical activity, dietary intake and symptom burden over time, and 3) using prospective, gold-standard measures of physical activity (i.e., triaxial accelerometry) and dietary intake (i.e., 24-hour diet recalls). Anthropomorphic and physical fitness factors will be assessed as potential mediators of physical activity and dietary intake on symptom burden and intensity. When our aims are accomplished we will have precise, definitive, high-quality data describing the impact of physical activity and diet on symptoms in PLHIV. These data can be used clinically to provide feedback to HIV health care providers on the physical activity and dietary intake of their patients. The PARADISE-HIV study will also have a significant scientific impact and will inform the next phase of this program of research. These findings will be used to develop an individually-targeted, clinic-based intervention to improve physical activity and dietary intake that will eventually reduce symptoms among PLHIV. They will also be used to examine biological and clinical mechanisms that lead to the prevalent unremitting symptoms experienced by PLHIV. Thus, the proposed study is likely to stimulate novel research that will have a long-term impact on the health and quality of life of PLHIV.

项目摘要/摘要： 患有艾滋病毒（PLHIV）的人经历了不成比例的高症状负担（例如疲劳，失眠， 疼痛）几乎没有治疗选择。这些症状经常出现，令人痛苦，经常同时发生，并且具有 对PLHIV的健康和福祉产生重大影响，但我们几乎一无所知 有效减轻它们。非药物治疗方案对于症状非常需要 PLHIV的管理已经经历了多种合并症的高药负担。我们的 团队以前报道说，体育锻炼和更好的营养与较低的症状有关 PLHIV的强度；但是，需要更清楚地了解体育锻炼和饮食的影响 确定这些方法如何减少该人群的症状困扰。以这些数据为基础 项目建议检查两种有希望的非药理策略的效果，即体育活动 惯例和饮食摄入，关于PLHIV的纵向症状经验（Paradise-HIV）。 Paradise-HIV研究是一项观察性的纵向研究，将利用大量 综合临床系统（CNIC）的艾滋病研究中心（CFAR）网络的基础设施 在四年内检查体育锻炼和饮食模式以及850 PLHIV的症状负担。这项研究 将发生在四个人口统计学多样化的艾滋病毒诊所[凯斯西部储备大学（俄亥俄州克利夫兰）， 阿拉巴马大学伯明翰（阿拉巴马州伯明翰），华盛顿大学（华盛顿西雅图） 和芬威卫生研究所（马萨诸塞州波士顿）]。天堂hiv将克服 先前的研究1）注册大型，人口统计学和地理上不同的，基于诊所的样本 PLHIV，2）检查体育锻炼，饮食摄入量和随着时间的症状负担之间的关系， 3）使用前瞻性的金色标准体育锻炼（即三轴加速度计）和饮食 摄入量（即24小时饮食回忆）。拟人化和身体健康因素将被评估为潜在 体育锻炼的介体和饮食摄入症状负担和强度的摄入量。当我们的目标是 完成的我们将拥有精确，确定的高质量数据，描述了物理的影响 PLHIV症状的活动和饮食。 这些数据可以在临床上用于向艾滋病毒医疗保健提供者提供有关身体的反馈 患者的活动和饮食摄入。天堂-HIV研究也将具有重要的科学 影响并将告知该研究计划的下一阶段。这些发现将用于开发 基于诊所的单独靶向，以改善体育锻炼和饮食摄入量，最终将 减轻PLHIV的症状。它们还将用于检查生物学和临床机制 导致PLHIV经历的普遍不易症状。因此，拟议的研究可能是 刺激新的研究，将对PLHIV的健康和生活质量产生长期影响。