Midcareer Investigator Award: Urban School Allergen Exposures and Childhood Asthm

职业生涯中期调查员奖：城市学校过敏原暴露和儿童哮喘

基本信息

批准号：
8667990
负责人：
WANDA PHIPATANAKUL
金额：
$ 18.31万
依托单位：
BOSTON CHILDREN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-06-01 至 2018-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8667990
关键词：
Accounting Address Affect Age Allergens Allergic Disease Asthma Award Biological Markers Blood Boxing Cells Child Childhood Childhood Asthma Clinical Clinical Research Collaborations Communities DNA DNA Methylation Data Education Ensure Environment Environmental Exposure Environmental Risk Factor Epigenetic Process Epithelial Cells Event Exposure to Extrinsic asthma Fostering Funding Gender Genes Genetic Goals Health Home environment Hypersensitivity Immunologist Incidence Inflammation Mediators Inflammatory Interferons Interleukin-6 Intervention Link Mediating Mentors Methylation Molds Molecular Morbidity - disease rate National Institute of Allergy and Infectious Disease Nose Outcome Pathogenesis Pathway interactions Public Health Research Research Activity Research Design Research Infrastructure Research Personnel Resources Risk Factors Role Running Schools Serum Severities Source Statistical Methods Students Symptoms Time United States United States National Institutes of Health Wheezing airway inflammation allergic airway disease allergic airway inflammation base career development cell type clinical epidemiology cohort cost design environmental intervention environmental stressor gene environment interaction human NOS2A protein immunoregulation improved inner city innovation novel patient oriented patient oriented research primary outcome programs public health relevance response

项目摘要

DESCRIPTION (provided by applicant): Childhood asthma, particularly in urban environments, is a source of significant morbidity. Children spend the majority of their day in school. The immediate goal of this project is to determine the role of changes in school-specific environmental exposures and genetic factors and asthma morbidity. The Candidate/PI is a board-certified allergist/immunologist with a MS in clinical epidemiology and runs a NIH funded asthma/allergy clinical research center. She has expertise in patient-oriented clinical research and mentoring. Her environment includes unparalleled community relationships, infrastructure, resources, and collaborators. Career Development Goals are to ensure that the candidate will be provided sufficient time for mentoring and patient oriented clinical research activities. The award will also allow her to further her education in statistical methods, study design, and gene-environment interactions to help her expand her patient oriented research program. This will allow us to move towards our overall goal of further our understanding of epigenetic/environmental interactions to design and implement more effective school focused interventions to reduce the severity and incidence of childhood asthma. The research hypothesis is that changes in classroom/school specific allergen/mold exposure levels will be associated with epigenetic changes in methylation, airway inflammation, and asthma symptoms. We will compare our methylation markers on selected genes potentially important in asthma with changes in the classroom-specific allergen/mold exposure and asthma health outcomes. We will also compare these results in a subset of age/gender matched students without asthma as controls attending the same classrooms to further the interpretation of our findings. The impact of this research may result in novel biomarkers that could inform us about the efficacy of school-based interventions against environmental exposures important to childhood asthma and its immune modulation, addressing a critical public health problem.

描述（由申请人提供）：童年哮喘，尤其是在城市环境中，是发病率明显的来源。孩子们大部分时间都在学校里度过。该项目的直接目标是确定学校特定环境暴露和遗传因素和哮喘发病率的变化的作用。候选人/PI是董事会认证的过敏症/免疫学家，具有临床流行病学的MS，并运营了NIH资助的哮喘/过敏临床研究中心。她在以患者为导向的临床研究和指导方面拥有专业知识。她的环境包括无与伦比的社区关系，基础架构，资源和合作者。职业发展目标是确保为候选人提供足够的时间来指导和以患者为导向的临床研究活动。该奖项还将使她能够进一步学习统计方法，研究设计和基因环境相互作用，以帮助她扩大以患者为导向的研究计划。这将使我们能够朝着进一步了解表观遗传/环境互动的理解，以设计和实施更有效的学校干预措施，以减少儿童哮喘的严重性和发病率。研究假设是，课堂/学校特定过敏原/霉菌暴露水平的变化将与甲基化，气道炎症和哮喘症状的表观遗传变化有关。我们将比较在哮喘中可能重要的基因上的甲基化标记与课堂特异性过敏原/霉菌暴露和哮喘健康结果的变化。我们还将在没有哮喘的年龄/性别匹配的一部分中比较这些结果，因为对照进行了同一教室，以进一步解释我们的发现。这项研究的影响可能会导致新型的生物标志物，可以告知我们对对童年哮喘重要的环境暴露及其免疫调节重要的环境暴露的疗效，从而解决了关键的公共健康问题。