Changes in sexual function following bariatric surgery

减肥手术后性功能的变化

• 批准号: 7681511
• 负责人: DAVID B SARWER
• 金额: $ 36.82万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-15 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7681511
• 关键词: Ancillary Study; Appearance; Area; Bariatrics; Behavioral Research; Body Image; Body Weight decreased; Clinical; Clinical Research; Clinical Trials; Comorbidity; Epidemiology; Gonadal Steroid Hormones; Hypertension; Individual; Investigation; Long-Term Effects; Measures; Medical; Morbid Obesity; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Operative Surgical Procedures; Participant; Patients; Persons; Pharmaceutical Preparations; Quality of life; Reporting; Research; Research Personnel; Sex Behavior; Sex Functioning; United States National Institutes of Health; Weight; Work; bariatric surgery; design; experience; improved; innovation; physical conditioning; response; satisfaction

DESCRIPTION (provided by applicant): This is an initial submission by a new investigator (Dr. David Sarwer) in response to RFA DK-03- 022 titled "Ancillary Studies to Obesity-Related Clinical Trials." This application is designed to serve as an ancillary study to the Bariatric Surgery Clinical Research Consortium, now referred to as Longitudinal Assessment of Bariatric Surgery (LABS). LABS is a six-center research consortium working in cooperation with National Institutes of Health (NIH) scientific staff to plan, develop, and conduct coordinated clinical,epidemiological, and behavioral research in bariatric surgery. This ancillary study, approved by the LABS Ancillary Study Committee, proposes to investigate changes in sexual function, sex hormones, body image, and marital functioning in 120 LABS participants and compare them with responses in 120 extremely obese individuals who do not undergo bariatric surgery. Patients who seek bariatric surgery are often motivated to lose weight to improve their physical health. Many patients also pursue surgery and the resulting weight loss to improve their quality of life and, morespecifically, their physical appearance and body image. Studies indicate that bariatric surgery confers these benefits. Few studies, however, have investigated more specific aspects of extremely obese individuals' quality of life, including sexual function. Similarly, there has been little investigation of changes in sex hormones following bariatric surgery and their potential relationship with changes in sexual function. The LABS consortium provides an excellent opportunity to investigate long-term changes in sexual function, sex hormones, body image, and marital satisfaction in individuals who undergo bariatric surgery for extreme obesity. The proposed study will assess changes in these domains as compared to changes experienced by extremely obese individuals who do not undergo bariatric surgery. The proposed study is innovative, as it will provide new and important information on the long-term effects of bariatric surgery on these important areas of quality of life.

描述（由申请人提供）： 这是一位新研究者（David Sarwer 博士）针对题为“肥胖相关临床试验的辅助研究”的 RFA DK-03-022 的回应而首次提交的材料。该应用程序旨在作为减肥手术临床研究联盟（现称为减肥手术纵向评估 (LABS)）的辅助研究。 LABS 是一个由六中心组成的研究联盟，与美国国立卫生研究院 (NIH) 的科研人员合作，规划、开发和开展减肥手术协调的临床、流行病学和行为研究。这项辅助研究经 LABS 辅助研究委员会批准，拟调查 120 名 LABS 参与者的性功能、性激素、身体形象和婚姻功能的变化，并将其与 120 名未接受减肥手术的极度肥胖者的反应进行比较。 寻求减肥手术的患者通常会主动减肥以改善身体健康。许多患者还寻求手术和由此产生的体重减轻，以改善他们的生活质量，更具体地说，改善他们的外表和身体形象。研究表明减肥手术具有这些益处。然而，很少有研究调查极度肥胖者生活质量的更具体方面，包括性功能。同样，对于减肥手术后性激素的变化及其与性功能变化的潜在关系也很少有研究。 LABS 联盟提供了一个绝佳的机会来研究因极度肥胖而接受减肥手术的个体性功能、性激素、身体形象和婚姻满意度的长期变化。拟议的研究将评估这些领域的变化，并与未接受减肥手术的极度肥胖者所经历的变化进行比较。拟议的研究具有创新性，因为它将提供有关减肥手术对生活质量这些重要领域的长期影响的新的重要信息。

项目成果

4-Year Changes in Sex Hormones, Sexual Functioning, and Psychosocial Status in Women Who Underwent Bariatric Surgery.

• DOI: 10.1007/s11695-017-3025-7
• 发表时间: 2018-04
• 期刊: Obesity surgery
• 影响因子: 2.9
• 作者: Sarwer DB;Wadden TA;Spitzer JC;Mitchell JE;Lancaster K;Courcoulas A;Gourash W;Rosen RC;Christian NJ
• 通讯作者: Christian NJ

Sexual functioning and sex hormones in men who underwent bariatric surgery.

• DOI: 10.1016/j.soard.2014.12.014
• 发表时间: 2015-05
• 期刊: Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery
• 作者: Sarwer DB;Spitzer JC;Wadden TA;Rosen RC;Mitchell JE;Lancaster K;Courcoulas A;Gourash W;Christian NJ
• 通讯作者: Christian NJ

Sexual functioning and sex hormones in persons with extreme obesity and seeking surgical and nonsurgical weight loss.

• DOI: 10.1016/j.soard.2013.07.003
• 发表时间: 2013-11
• 期刊: Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery
• 作者: Sarwer DB;Spitzer JC;Wadden TA;Rosen RC;Mitchell JE;Lancaster K;Courcoulas A;Gourash W;Christian NJ
• 通讯作者: Christian NJ