Patient-oriented Research: Colon CA & Cancer Immunology
以患者为导向的研究:Colon CA
基本信息
- 批准号:7251986
- 负责人:
- 金额:$ 14.86万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2001
- 资助国家:美国
- 起止时间:2001-04-19 至 2011-03-31
- 项目状态:已结题
- 来源:
- 关键词:10qAXIN2 geneAcademiaAcademic Medical CentersActivities of Daily LivingAdjuvantAdultAdverse eventAffectAgarAgar Gel ElectrophoresisAlkaline PhosphataseAmerican Association of Cancer ResearchAmerican Society of Clinical OncologyAmerican Society of HematologyAmino AcidsAnatomyAncillary StudyAnimal ModelAntibodiesAntigen PresentationAntigen Presentation PathwayAntigen-Presenting CellsAntigensAntineoplastic AgentsAntioxidantsAntisense RNAApoptosisApoptoticAppearanceAppendixApplications GrantsAreaArmadillo RepeatAtrial Natriuretic FactorAutomobile DrivingAwardB-LymphocytesBMP4Basement membraneBindingBinding SitesBiochemistryBioflavonoidBiologicalBiological AssayBiological MarkersBiological ModelsBiological SciencesBiometryBionBiopsyBiopsy SpecimenBiotechnologyBloodBlood CirculationBone Marrow SuppressionBostonBrachyury proteinBuffersC-terminalCC chemokine receptor 7CCND1 geneCCND2 geneCCR1 geneCCR5 geneCCR8 geneCD19 geneCD44 geneCD80 geneCMV promoterCOL1A1 geneCSF2 geneCTBP1 geneCTBP2 geneCTNNB1 geneCXCR4 geneCadherinsCalciumCaliforniaCancer BiologyCancer CenterCancer EtiologyCancer Immunology ScienceCancer PatientCancer Therapy Evaluation ProgramCancer cell lineCancerousCapecitabine/OxaliplatinCase Report FormCategoriesCell CountCell Cycle ProteinsCell LineCell LineageCell NucleusCell ProliferationCell Proliferation RegulationCell Surface ReceptorsCell physiologyCell surfaceCellsCellular AssayCellular StructuresCellular biologyCetuximabCharacteristicsChemopreventionClassClassificationClinicClinicalClinical InvestigatorClinical MedicineClinical NutritionClinical OncologyClinical ProtocolsClinical ResearchClinical Research ProtocolsClinical TreatmentClinical TrialsClinical Trials DesignClinical trial protocol documentCoculture TechniquesColonColon CarcinomaColonic NeoplasmsColonic PolypsColonoscopyColorectalColorectal CancerCommitCommon NeoplasmCommunity HealthComplementComplementary DNAComplexComprehensive Cancer CenterConditionConfocal MicroscopyConnexin 43ContractsControlled EnvironmentCorrelative StudyCost Effectiveness AnalysisCouplingCrabsCulture MediaCultured CellsCytolysisCytoplasmCytoskeletonCytotoxic ChemotherapyDNADNA Microarray ChipDNA Microarray formatDailyDataDendritic CellsDepthDescriptive EpidemiologyDetectionDevelopmentDevelopmental Cell BiologyDevicesDiagnosisDietary AssessmentDigoxigeninDimethyl SulfoxideDisciplineDiseaseDissectionDoctor of PhilosophyDocumentationDominant-Negative MutationDoseDown-RegulationDrug resistanceE-CadherinE250EP300 geneEarly DiagnosisEcologyEconomicsEctopic ExpressionEducational CurriculumEffectivenessEligibility DeterminationEmbryoEmbryonic DevelopmentEnd PointEndothelial CellsEnrollmentEnvironmental EpidemiologyEnvironmental HealthEnzymesEpidemiologyEpidermal Growth Factor ReceptorEpithelialEpithelial CellsEpitheliumEtiologyEvaluable DiseaseEvaluationEventExcisionExhibitsExperimental DesignsExposure toExtracellular ProteinExtramural ActivitiesFGF4 geneFOSL1 geneFRAT1 geneFZD2 geneFZD3 geneFZD4 geneFZD6 geneFZD7 geneFZD9 geneFacultyFamilyFamily memberFeedbackFellowshipFellowship ProgramFlow CytometryFluorescenceFluorescence MicroscopyFluorochromeFluorouracilFluorouracil/Irinotecan/Leucovorin CalciumFluorouracil/Leucovorin CalciumFollistatinFormalinFoundationsFreezingFresh TissueFundingFutureGTP-Binding ProteinsGastric GlandsGastric TissueGastrinsGastroenterologyGelatinase AGene ExpressionGene Expression RegulationGene TargetingGenesGeneticGenetic TranscriptionGenus ColaGerm-Line MutationGermanyGlutathione S-TransferaseGoalsGrantGranulocyte-Macrophage Colony-Stimulating FactorGrapesGroup MeetingsGrowthGrowth FactorHST OncogeneHT29 CellsHandHeadHealthHealth Care CostsHealth ServicesHematologyHemeHereditary Nonpolyposis Colorectal NeoplasmsHistologicHomeostasisHourHumanHuman ResourcesHydrolysisICAM1 geneID2 geneIL3RA geneITGAX geneImageryImmuneImmune responseImmune systemImmunizationImmunohistochemistryImmunologicsImmunologyImmunosuppressionIn SituIn Situ HybridizationIn VitroIncubatedIndiumIndividualInflammatoryInflammatory Bowel DiseasesInformed ConsentInheritedInstitutesInstructionIntegrin alpha3Interferon Type IIInterferonsIntervention StudiesIntestinal MucosaInvestigationJUN geneJournalsK-Series Research Career ProgramsLabelLaboratoriesLaboratory ResearchLaboratory ScientistsLaboratory StudyLasersLeadLeadershipLengthLettersLevamisoleLife ExpectancyLigandsLocalized DiseaseLocationLouisianaLuc GeneLungMAPK8 geneMHC Class I GenesMHC Class II GenesMSX1 geneMYB geneMaintenanceMalignant - descriptorMalignant NeoplasmsMalignant neoplasm of lungMalignant neoplasm of nasopharynxMalignant neoplasm of pancreasMalignant neoplasm of prostateManufacturer NameManuscriptsMarketingMatrix MetalloproteinasesMeasurementMeasuresMediatingMedicalMedical OncologyMedical ResearchMedical StudentsMedicineMembraneMentored Clinical Oncology AwardMentored Clinical Scientist AwardMentored Patient-Oriented Research Career Development AwardMentorsMentorshipMessenger RNAMetastatic/RecurrentMethodologyMethodsMicroarray AnalysisMicrobiologyMicrosatellite InstabilityMid-Career Clinical Scientist Award (K24)Midcareer Investigator Award in Patient-Oriented ResearchMinorModelingMolecularMolecular AnalysisMolecular BiologyMolecular GeneticsMolecular ProfilingMonitorMonoclonal AntibodiesMorusMucous MembraneMusMutateMutationNCAM1 geneNOS2A geneNamesNational Institute of Diabetes and Digestive and Kidney DiseasesNational Surgical Adjuvant Breast and Bowel ProjectNatural Killer CellsNeckNeoplasm MetastasisNeutropeniaNorthern BlottingNuclearNucleic Acid Regulatory SequencesNumbersNurse PractitionersNursesNursing FacultyNutritional StudyNylonsOffice of the DirectorOligonucleotide PrimersOligonucleotide ProbesOncologic NursingOncology NurseOperative Surgical ProceduresOrganOrthopedicsOryctolagus cuniculusOutcomeOxidation-ReductionPLAUR genePPP2R5D genePTGS2 genePathogenesisPathologicPathway interactionsPatient CarePatient SchedulesPatientsPatternPeanuts - dietaryPeer ReviewPerceptionPeripheralPeripheral Blood Mononuclear CellPharmaceutical PreparationsPharmacologic SubstancePharmacologyPhasePhase II Clinical TrialsPhenotypePhosphotransferasesPhysiciansPilot ProjectsPlacementPlantsPlasmidsPlayPolymerase Chain ReactionPopulationPopulation GroupPositioning AttributePostdoctoral FellowPre-studyPredispositionPremalignantPreparationPreventionPreventiveProbenecidProceduresProcessProductionProtein Kinase CProtein OverexpressionProtein Phosphatase 2A Regulatory Subunit PR53ProteinsProto-Oncogene Proteins c-junProto-Oncogene Proteins c-mybProtocols documentationPublic HealthPublicationsPublishingPurposeRNARNA ProbesRangeRateReaderReagentReceptor SignalingRecombinant DNARecommendationRecruitment ActivityRectal CancerRecurrenceRefractoryRegulationReporterReportingResearchResearch ActivityResearch DesignResearch Ethics CommitteesResearch PersonnelResearch Project GrantsResearch ProposalsResearch TrainingResourcesRestResveratrolReverse Transcriptase Polymerase Chain ReactionReview CommitteeRiskRoleRotationSFRP4 geneSample SizeSamplingSchoolsScientistScoreSecureSentinelSequence AnalysisSeriesSideSignal PathwaySignal TransductionSignaling MoleculeSignaling Pathway GeneSimplexvirusSiteSkinSlideSmall Interfering RNASocietiesSolutionsSourceSouthwest Oncology GroupSpecificitySpecimenStagingStaining methodStainsStandards of Weights and MeasuresStem cellsStomachStressStudentsStudy SectionSubgroupSulindacSupport of ResearchSurrogate EndpointSurrogate MarkersSystemT-LymphocyteTATA BoxTCF7L2 geneTP53 geneTechniquesTechnologyTestingTherapeuticTherapeutic Clinical TrialTherapeutic EffectTherapeutic TouchTherapeutic immunosuppressionTherapy Clinical TrialsThymidine KinaseTimeTissue SampleTissuesTitleTopoisomerase I inhibitionToxic effectTrainingTraining ProgramsTranscriptional ActivationTransfectionTranslational ResearchTreatment EffectivenessTumor AngiogenesisTumor AntigensTumor Cell InvasionTumor ImmunityTumor TissueTumor-DerivedUnited States Food and Drug AdministrationUnited States National Institutes of HealthUniversitiesUniversity of California Irvine Cancer CenterUp-RegulationVaccinesVariantVascular Endothelial Growth FactorsVenous blood samplingWNT1 geneWNT10A geneWNT11 geneWNT2 geneWNT2B geneWNT3 geneWNT4 geneWNT5A geneWNT5A proteinWNT6 geneWNT7A geneWNT9A geneWagesWeekWestern BlottingWnt proteinsWorkWritingabstractingangiogenesisanticancer researchbacteriophage T3 RNA polymerasebasebeta cateninc-myc GenescDNA Arrayscancer cellcancer diagnosiscancer epidemiologycancer immunology functioncancer preventioncancer research center directorcancer typecapsulecareercelecoxibcell growthcell motilitychemokinechemokine receptorchemotherapychiron vaccinecohortcolon cancer cell linecolon carcinogenesiscolonic cryptconceptcostcyclooxygenase 2cytokinedaydesigndietary supplementsdisorder controldosageepithelial to mesenchymal transitionexperienceextracellularfunctional genomicsgastrointestinalgenetic epidemiologyhuman MMP14 proteinhuman NOS2A proteinhuman PPP2R5D proteinhuman SFRP4 proteinhuman WNT10A proteinhuman WNT11 proteinhuman WNT2 proteinhuman WNT2B proteinhuman WNT3 proteinhuman WNT4 proteinhuman WNT6 proteinhuman WNT7A proteinhuman WNT9A proteinhuman studyimmune functionimmunoregulationimprovedin vivoinhibitor/antagonistinstructorinterestiron metabolismjun Oncogenelaser capture microdissectionlymph nodeslymphoid enhancer-binding factor 1mRNA Expressionmalignant breast neoplasmmalignant stomach neoplasmmatrigelmatrix metalloproteinase 26medical schoolsmembermigrationmolecular oncologymonocytemutantneoplasticneoplastic cellnovelnovel strategiesnovel therapeuticsoncologyosteosarcomaoutcome forecastoxaliplatinpatient orientedpatient oriented researchperipheral bloodprofessorprogenitorprogramspromoterprotein activationprotein expressionproto-oncogene protein kfgfquality assurancereceptorreceptor expressionreconstitutionred winerelease of sequestered calcium ion into cytoplasmrepairedresearch studyresponserhoslugsocialstatisticssuccesssymposiumtraffickingtranscription factortranslational clinical trialtrendtrizoltumortumor growthtumor immunologytumor progressiontumorigenesistype I collagen alpha 1uncontrolled cell growthvectorvector control
项目摘要
DESCRIPTION (provided by applicant): This application is submitted as a competitive renewal of a midcareer investigator award in patient-oriented research (K24CA82450). The PI is Randall F. Holcombe, MD. This application details the experience, qualifications and short- and long-term patient-oriented research plans of Dr. Holcombe, as well as reviews progress during the period of support under the current award. Details about current and planned patient- oriented research is provided. These studies are focused on patient-oriented research in colon cancer and include studies related to the Wnt signaling pathway, elucidation of immunologic events in conjunction with administration of chemotherapy for colon cancer and definition of the mechanisms and potential therapeutic and cancer preventive effects of resveratrol, a naturally occuring compound found in the skin of grapes. Patients with inflammatory bowel disease, having or at high risk for colon cancer, are also studied. An additional clinical trial with laboratory correlative studies, originally designed and written by a mentee hematology-oncology fellow of Dr. Holcombe's involves the treatment of patients with gastric cancer. Mentoring activity over the past 5 years and mentoring plans for the next 5 years are described. The accomplishments of mentees are outlined as are their current activities, especially as related to ongoing participation in patient-oriented research. Ongoing mentoring plans include formal coursework, basic/translational research experiences, instruction in the development and implementation of clinical research trials, and hands-on experiences in clinical research. The original goals and objectives of the current award are reviewed and the extent to which these have been achieved is delineated. Documentation of institutional support and justification of the need for continued support through the K24 mechanism is provided.
描述(由申请人提供):本申请是作为以患者为导向的研究中职业生涯中期研究者奖的竞争性更新而提交的(K24CA82450)。 PI 是医学博士 Randall F. Holcombe。该申请详细介绍了 Holcombe 博士的经验、资质以及短期和长期以患者为导向的研究计划,并回顾了当前奖项支持期间的进展。提供了有关当前和计划的以患者为导向的研究的详细信息。这些研究侧重于以患者为导向的结肠癌研究,包括与 Wnt 信号通路相关的研究、阐明与结肠癌化疗相关的免疫事件以及白藜芦醇的机制和潜在治疗和癌症预防作用的定义,葡萄皮中天然存在的化合物。还对患有结肠癌或具有高风险结肠癌的炎症性肠病患者进行了研究。另一项涉及实验室相关研究的临床试验最初是由 Holcombe 博士的一名血液肿瘤学研究员设计和撰写的,涉及胃癌患者的治疗。描述了过去5年的辅导活动和未来5年的辅导计划。概述了受训者的成就以及他们当前的活动,特别是与持续参与以患者为导向的研究相关的成就。持续的指导计划包括正式课程、基础/转化研究经验、临床研究试验开发和实施的指导以及临床研究的实践经验。审查了当前奖项的最初目标和目标,并描述了这些目标已实现的程度。提供了机构支持的文件以及通过 K24 机制持续支持的必要性的理由。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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RANDALL F HOLCOMBE其他文献
RANDALL F HOLCOMBE的其他文献
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{{ truncateString('RANDALL F HOLCOMBE', 18)}}的其他基金
Neoadjuvant photodynamic immunomodulation for colon cancer
结肠癌新辅助光动力免疫调节
- 批准号:
8005456 - 财政年份:2010
- 资助金额:
$ 14.86万 - 项目类别:
Neoadjuvant photodynamic immunomodulation for colon cancer
结肠癌新辅助光动力免疫调节
- 批准号:
8119595 - 财政年份:2010
- 资助金额:
$ 14.86万 - 项目类别:
PHASE I BIOMARKER STUDY OF DIETARY GRAPE-DERIVED LOW DOSE RESVERATROL FOR COLON
膳食葡萄源低剂量白藜芦醇对结肠的 I 期生物标志物研究
- 批准号:
8166926 - 财政年份:2009
- 资助金额:
$ 14.86万 - 项目类别:
PHASE I BIOMARKER STUDY OF DIETARY GRAPE-DERIVED LOW DOSE RESVERATROL FOR COLON
膳食葡萄源低剂量白藜芦醇对结肠的 I 期生物标志物研究
- 批准号:
7951074 - 财政年份:2008
- 资助金额:
$ 14.86万 - 项目类别:
A Phase 1 Study of CCI-779 in Combination with Imatnib *
CCI-779 与伊马尼布联合的 1 期研究 *
- 批准号:
7087072 - 财政年份:2005
- 资助金额:
$ 14.86万 - 项目类别:
Wnt Signaling in IBD-Related Colon Cancer
IBD 相关结肠癌中的 Wnt 信号转导
- 批准号:
6850894 - 财政年份:2004
- 资助金额:
$ 14.86万 - 项目类别:
Wnt Signaling in IBD-Related Colon Cancer
IBD 相关结肠癌中的 Wnt 信号转导
- 批准号:
6703346 - 财政年份:2004
- 资助金额:
$ 14.86万 - 项目类别:
Patient oriented Research--Colon CA & Cancer Immunology
以患者为导向的研究--Colon CA
- 批准号:
6327470 - 财政年份:2001
- 资助金额:
$ 14.86万 - 项目类别:
Patient oriented Research--Colon CA & Cancer Immunology
以患者为导向的研究--Colon CA
- 批准号:
6874525 - 财政年份:2001
- 资助金额:
$ 14.86万 - 项目类别:
Patient-oriented Research: Colon CA & Cancer Immunology
以患者为导向的研究:Colon CA
- 批准号:
7586771 - 财政年份:2001
- 资助金额:
$ 14.86万 - 项目类别:
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