Patient oriented Research--Colon CA & Cancer Immunology

以患者为导向的研究--Colon CA

• 批准号: 6874525
• 负责人: RANDALL F HOLCOMBE
• 金额: $ 12.7万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-19 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6874525
• 关键词: cadherins; cancer prevention; colon neoplasms; combination cancer therapy; difluoromethylornithine; flow cytometry; fluorouracil; human subject; human therapy evaluation; in situ hybridization; interleukin 2; leucovorin; levamisole; microarray technology; neoplasm /cancer chemotherapy; neoplasm /cancer immunology; neoplasm /cancer immunotherapy; neoplasm /cancer relapse /recurrence; patient oriented research

DESCRIPTION (provided by applicant): This application details the experience, qualifications and short- and long-term plans for the patient-oriented research and mentoring activities of Randall F. Holcombe, MD, Chief of Hematology/Oncology at the University of California, Irvine and Associate Director for Clinical Research of the Chao Family Comprehensive Cancer Center. Since completion of Hematology/Oncology sub-specialty training in 1989, Dr. Holcombe has established an academic career in clinical and translational patient-oriented research involving both clinical and basic investigations in the areas of oncology, immunology and genetics. He has been successful in conducting clinical/translational trials and in obtaining extramural support for these activities. Currently and over the past several years, he has also been active in mentoring beginning clinical investigators. This application for the Midcareer Investigator Award in Patient-Oriented Research will provide support to allow Dr. Holcombe to continue and expand upon these activities. This application will outline proposed research and mentoring activities, institutional support for these activities, and documentation of Dr. Holcombe's commitment to a career in patient-oriented research. This is a second revision of a Midcareer Investigator Award in Patient-Oriented Research (K24) initially submitted 10/1/98, with a first revision submitted 7/1/99. Substantial modifications in response to questions raised in the first summary statement were included in the first revision. While minimal criticisms of the proposal were noted in the second summary statement, additional information that further strengthens the application has been provided in preparation of this second revision.

描述（由申请人提供）：此申请详细介绍了经验， 以患者为中心的资格以及短期和长期计划 Randall F. Holcombe 医学博士的研究和指导活动 加州大学欧文分校血液学/肿瘤学及副教授 曹氏综合癌症中心临床研究主任。 自 1989 年完成血液学/肿瘤学亚专业培训以来， Holcombe 博士在临床和转化领域建立了学术生涯 以患者为导向的研究，涉及临床和基础研究 肿瘤学、免疫学和遗传学领域。 他已经成功地 进行临床/转化试验并获得外部支持 对于这些活动。 目前以及过去几年，他还 积极指导刚起步的临床研究人员。 这个应用程序 以患者为导向的研究中的职业生涯中期研究员奖将提供 支持 Holcombe 博士继续并扩大这些活动。 该申请将概述拟议的研究和指导活动， 对这些活动的机构支持以及 Holcombe 博士致力于以患者为中心的研究事业。 这是职业生涯中期调查员奖的第二次修订 以患者为导向的研究 (K24) 最初于 10/1/98 提交，第一个 修订于 99 年 7 月 1 日提交。 针对问题的答复进行重大修改 第一份摘要声明中提出的内容已包含在第一次修订中。 虽然第二份摘要中对该提案提出了极少的批评 声明，进一步加强应用程序的附加信息 已在准备第二次修订时提供。