Dietary Intake and Eating Behavior in Adolescents who Undergo Bariatric Surgery

接受减肥手术的青少年的膳食摄入量和饮食行为

• 批准号: 7640555
• 负责人: DAVID B SARWER
• 金额: $ 32.85万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7640555
• 关键词: Adolescent; Adult; American; Americas; Ancillary Study; Area; Attention; Behavioral; Binge Eating; Body Weight decreased; Calories; Clinical; Clinical Research; Clinical Trials; Comorbidity; Country; Coupled; Development; Diet Habits; Dietary intake; Disease; Disinhibition; Doctor of Medicine; Eating Behavior; Educational Background; Effectiveness; Epidemic; Ethnic Origin; Family; Health; Hunger; Impairment; Income; Intervention Studies; Life; Life Expectancy; Life Style; Modification; Morbid Obesity; Nausea and Vomiting; Obesity; Operative Surgical Procedures; Outcome; Participant; Patient Self-Report; Patients; Pharmacological Treatment; Physical activity; Play; Postoperative Period; Prevalence; Quality of life; Reporting; Research; Resolution; Role; Safety; Sampling; Schools; Stomach; Teenagers; Time; United States National Institutes of Health; Weight; Work; Youth; bariatric surgery; design; experience; health related quality of life; innovation; interest; physical conditioning; programs; psychosocial; public health relevance; response; restraint; sugar

DESCRIPTION (provided by applicant): This is an initial submission in response to PAR-07-024 (originally PAR-06-216) titled "Ancillary Studies to Obesity-Related Clinical Trials." This application is designed to serve as an ancillary study to the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS; U01 DK072493; PI: Thomas Inge, M.D.) consortium. Teen-LABS is a four-center consortium working in cooperation with NIH scientific staff to conduct coordinated clinical research in adolescents who undergo bariatric surgery. This ancillary study, approved by the Teen-LABS Ancillary Study Committee, proposes to investigate changes in dietary intake and eating behavior in 110 Teen-LABS participants and compare them with responses in 110 obese adolescents treated with a lifestyle modification program. As America's obesity problem continues to grow, there is a need for additional research on the effectiveness of innovative treatments. Bariatric surgery for adults with extreme obesity has exploded in popularity over the past decade. The sizable weight losses seen with bariatric surgery are well maintained and accompanied by improvement, if not resolution, of several obesity-related comorbidities and psychosocial status. Postoperative changes in dietary intake and eating behavior, which are thought to play a critical role in postoperative outcomes, have received less attention. The dietary and eating behavior outcomes of bariatric surgery in adolescents are virtually unknown. These issues may be particularly important because of adolescents' developmental status at the time of surgery as well as their longer life expectancy. The main trial of the Teen-LABS consortium will not specifically study changes in dietary intake and eating behavior before and after bariatric surgery. We propose to study postoperative changes in these areas in a subset of 110 adolescents who undergo bariatric surgery in Teen-LABS. We predict that these adolescents will report significant improvements in their dietary intake (including reduced total calories per day and decreases in percentage of calories from sugar) at 6, 12, and 24 months postoperatively as compared to obese adolescents treated with a lifestyle modification program. We also anticipate that adolescents who undergo bariatric surgery will report greater improvements in eating behavior (including less frequent binge eating, higher levels of dietary restraint, as well as lower levels of disinhibition and hunger) as compared to obese adolescents treated in the lifestyle modification program. The Teen-LABS consortium provides an ideal opportunity to complete this innovative ancillary study in a large and diverse sample of adolescents who undergo bariatric surgery. PUBLIC HEALTH RELEVANCE: In the proposed ancillary study to the Teen-LABS consortium, we plan to investigate changes in dietary intake and eating behavior in adolescents who undergo bariatric surgery.

描述（由申请人提供）： 这是针对 PAR-07-024（原 PAR-06-216）标题为“肥胖相关临床试验的辅助研究”的初步提交。该应用程序旨在作为青少年减肥手术纵向评估 (Teen-LABS; U01 DK072493; PI: Thomas Inge, M.D.) 联盟的辅助研究。 Teen-LABS 是一个由四中心组成的联盟，与 NIH 科学人员合作，对接受减肥手术的青少年进行协调的临床研究。这项辅助研究得到了 Teen-LABS 辅助研究委员会的批准，拟调查 110 名 Teen-LABS 参与者的膳食摄入量和饮食行为变化，并将其与接受生活方式改变计划的 110 名肥胖青少年的反应进行比较。 随着美国的肥胖问题持续恶化，需要对创新疗法的有效性进行更多研究。在过去的十年里，针对极度肥胖的成年人的减肥手术迅速普及。减肥手术后的显着体重减轻得到了很好的维持，并且伴随着一些与肥胖相关的合并症和心理社会状态的改善（如果不是解决的话）。术后膳食摄入和饮食行为的变化被认为对术后结果起着关键作用，但很少受到关注。青少年减肥手术的饮食和饮食行为结果实际上是未知的。由于青少年在手术时的发育状况以及较长的预期寿命，这些问题可能特别重要。 Teen-LABS 联盟的主要试验不会专门研究减肥手术前后饮食摄入量和饮食行为的变化。我们建议研究在 Teen-LABS 中接受减肥手术的 110 名青少年中这些区域的术后变化。我们预测，与接受生活方式改变计划的肥胖青少年相比，这些青少年在术后 6、12 和 24 个月时的饮食摄入量将显着改善（包括每天总热量的减少和糖热量百分比的降低）。我们还预计，与接受生活方式改变计划的肥胖青少年相比，接受减肥手术的青少年的饮食行为将有更大的改善（包括更少的暴饮暴食、更高水平的饮食限制以及更低的去抑制和饥饿水平） 。 Teen-LABS 联盟提供了一个理想的机会，可以在大量接受减肥手术的青少年样本中完成这项创新辅助研究。 公共健康相关性：在向青少年实验室联盟提出的辅助研究中，我们计划调查接受减肥手术的青少年的膳食摄入和饮食行为的变化。