Genetics of Chronic Kidney Disease

慢性肾脏病的遗传学

基本信息

批准号：
7575820
负责人：
STEPHEN T TURNER
金额：
$ 45.99万
依托单位：
MAYO CLINIC ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-02-20 至 2011-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7575820
关键词：
Adult African African American Age Albumins Albuminuria American Animal Model Arterial Disorder Arteriosclerosis Blood Pressure Blood Vessels Body Size Body Surface Area C-reactive protein Candidate Disease Gene Cardiac Cerebrum Cessation of life Chronic Kidney Failure Creatinine Diabetes Mellitus Dialysis procedure Disease Marker Dyslipidemias European Fibrinogen Genes Genetic Genetic Polymorphism Genome Glomerular Filtration Rate Gold Homocysteine Homocystine Human Hypertension Incidence Individual Investigation Iothalamate Kidney Diseases Kidney Transplantation Knowledge LDL Cholesterol Lipoproteins Lead Link Lipoprotein (a)Measures Methods Mexican Americans Myocardial Infarction Peripheral Population Predisposition Prevalence Research Personnel Risk Risk Factors Role Serum Serum Markers Severities Siblings Smoke Stroke Tandem Repeat Sequences Urine Woman cohort cost genetic epidemiology genome-wide linkage high risk member men nephrogenesis novel post gamma-globulins prevent programs sex

项目摘要

Chronic kidney disease (CKD) afflicts 11% of the adult US population. Susceptibility to CKD varies considerably, suggesting a role for genetic factors. Knowledge of genetic predictors of CKD may lead to better methods of identifying and treating individuals at risk to prevent the rising incidence and prevalence of endstage renal disease. The Genetic Epidemiology Network of Arteriopathy (GENOA) has conducted genomewide linkage and association studies to identify genes influencing blood pressure and the arteriosclerotic cerebral, cardiac, and peripheral vascular complications of hypertension. The proposed investigation will extend those efforts by identifying genetic predictors of CKD in previously well-characterized European-white and African- American sibships with 2 or more hypertensive members. We propose to identify genetic predictors of CKD in these ethnically diverse, high-risk cohorts by accomplishing the following specific aims: Aim 1: Determine whether conventional or novel risk factors for arteriosclerosis (already measured by GENOA) predict glomerular filtration rate or albuminuria in 1000 European-white and 1000 African-American siblings. Aim 2: Determine whether diallelic polymorphisms in >250 candidate genes for hypertension or its arteriosclerotic cerebral, cardiac, and peripheral vascular vascular complications (already measured by GENOA) predict glomerular filtration rate or albuminuria in 1000 European-white and 1000African-American siblings. Aim 3: Determine whether any of 387 highly polymorphic tandem repeat marker loci spanning the genome (already measured by GENOA) are linked to genes influencing glomerular filtration rate or albuminuria in more than 1000 European-white and 1000 African-Americansibling pairs.

慢性肾脏疾病（CKD）折磨了美国成年人口的11％。 CKD的敏感性各不相同相当大，提出了遗传因素的作用。 CKD的遗传预测因素的了解可能导致更好地识别和治疗处于风险的人以防止发病率上升和流行的方法末期肾脏疾病。动脉疾病的遗传流行病学网络（Genoa）进行了全基因组的联系和关联研究以鉴定影响血压和动脉硬化大脑，心脏，心脏的基因和高血压的外周血管并发症。拟议的调查将扩大这些努力通过确定以前特征良好的欧洲白人和非洲的遗传预测因子有2个或更多高血压成员的美国人。我们建议确定CKD的遗传预测因子在这些种族多样化的高风险人群中，通过实现以下特定目标：目标1：确定动脉硬化的常规风险因素还是新的风险因素（已经通过 Genoa）预测1000欧洲白人和1000名非裔美国人的肾小球过滤率或蛋白尿兄弟姐妹。 AIM 2：确定> 250个候选基因的高血压或ITS的拨号多态性是动脉粥样硬化脑，心脏和周围血管并发症（已经通过 GENOA）预测1000欧洲白人和1000名非洲人的肾小球过滤率或蛋白尿兄弟姐妹。目标3：确定387个高度多态串联重复标记基因座是否跨越基因组（已经通过热那亚测量）与影响肾小球滤过率或蛋白尿的基因有关超过1000个欧洲白人和1000个非洲裔美国人对。