Genetics of Chronic Kidney Disease

慢性肾脏病的遗传学

基本信息

批准号：
7189091
负责人：
STEPHEN T TURNER
金额：
$ 47.9万
依托单位：
MAYO CLINIC ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-02-20 至 2011-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7189091
关键词：
Adult African African American Age Albumins Albuminuria Animal Model Arterial Disorder Arteriosclerosis Blood Pressure Blood Vessels Body Size Body Surface Area C-reactive protein Candidate Disease Gene Cardiac Cerebrum Cessation of life Chronic Kidney Failure Creatinine Diabetes Mellitus Dialysis procedure Disease Marker Dyslipidemias European Fibrinogen Genes Genetic Genetic Polymorphism Genome Glomerular Filtration Rate Gold Homocysteine Homocystine Human Hypertension Incidence Individual Investigation Iothalamate Kidney Diseases Kidney Transplantation Knowledge LDL Cholesterol Lipoproteins Lead Link Lipoprotein (a)Lipoprotein (a-)Measures Methods Mexican Americans Myocardial Infarction Peripheral Physical Dialysis Population Predisposition Prevalence Research Personnel Risk Risk Factors Role Serum Serum Markers Severities Siblings Smoke Standards of Weights and Measures Stroke Tandem Repeat Sequences Urine Woman cohort cost genetic epidemiology member men nephrogenesis novel post gamma-globulins prevent programs sex

项目摘要

DESCRIPTION (provided by applicant): Chronic kidney disease (CKD) afflicts 11% of the adult US population. Susceptibility to CKD varies considerably, suggesting a role for genetic factors. Knowledge of genetic predictors of CKD may lead to better methods of identifying and treating individuals at risk to prevent the rising incidence and prevalence of endstage renal disease. The Genetic Epidemiology Network of Arteriopathy (GENOA) has conducted genomewide linkage and association studies to identify genes influencing blood pressure and the arteriosclerotic cerebral, cardiac, and peripheral vascular complications of hypertension. The proposed investigation will extend those efforts by identifying genetic predictors of CKD in previously well-characterized European-white and African- American sibships with 2 or more hypertensive members. We propose to identify genetic predictors of CKD in these ethnically diverse, high-risk cohorts by accomplishing the following specific aims: Aim 1: Determine whether conventional or novel risk factors for arteriosclerosis (already measured by GENOA) predict glomerular filtration rate or albuminuria in 1000 European-white and 1000 African-American siblings. Aim 2: Determine whether diallelic polymorphisms in >250 candidate genes for hypertension or its arteriosclerotic cerebral, cardiac, and peripheral vascular vascular complications (already measured by GENOA) predict glomerular filtration rate or albuminuria in 1000 European-white and 1000 African-American siblings. Aim 3: Determine whether any of 387 highly polymorphic tandem repeat marker loci spanning the genome (already measured by GENOA) are linked to genes influencing glomerular filtration rate or albuminuria in more than 1000 European-white and 1000 African-American sibling pairs.

描述（由申请人提供）：慢性肾脏疾病（CKD）折磨于美国成年人口的11％。 CKD的敏感性差异很大，这表明遗传因素的作用。 CKD遗传预测因子的知识可能会导致更好地识别和治疗有风险的人，以防止终端肾脏疾病的发病率上升和患病率上升。动脉炎的遗传流行病学网络（Genoa）进行了全基因组联系和关联研究，以鉴定影响血压和动脉硬化大脑，心脏和外周血管并发性高血压的基因。拟议的调查将通过确定以前特征良好的欧洲白人和非裔美国人的遗传预测因素来扩展这些努力，并具有2个或更多高血压成员。我们建议通过完成以下特定目的来鉴定这些种族多样化的高风险队列中CKD的遗传预测因子：目标1：确定动脉粥样硬化的常规或新颖的风险因素（已经通过Genoa衡量）是否预测了1000欧洲欧洲和1000次非洲非洲人和1000次非洲非洲人 - 美洲 - 美洲 - 美洲 - 蛋白尿的肾小球过滤速率或白蛋白尿。 AIM 2：确定> 250种高血压候选基因中的拨号多态性或其动脉硬化脑，心脏和周围血管血管并发症（已经通过GENOA测量）是否可以预测1000欧洲欧洲和1000名非洲非洲人 - 非洲人 - 非洲人 - 美ammerican-American-American-American Sii-siblings的肾小球过滤率或白蛋白尿素。 AIM 3：确定跨基因组的387个高度多态串联重复标记基因座（已经由Genoa测量）是否与影响肾小球过滤率的基因或1000多个欧洲白人和1000多个非洲人裔美国人同胞对的基因有关。