A Low-Cost Cardiac Annunciator to Reduce Stillbirths and Neonatal Deaths

降低死产和新生儿死亡的低成本心脏信号器

• 批准号: 8266953
• 负责人: MICHAEL R NEUMAN
• 金额: $ 10.97万
• 依托单位: MICHIGAN TECHNOLOGICAL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-01 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8266953
• 关键词: Achievement; Area; Biomedical Engineering; Birth; Cardiac; Cessation of life; Charge; Chest; Clinical; Clinical Research; Complex; Country; Detection; Developed Countries; Developing Countries; Development; Device Designs; Devices; Distress; Effectiveness; Electrocardiogram; Electrodes; Electronics; Engineering; Ensure; Environmental air flow; Equipment; Evaluation; Feedback; Goals; Grant; Heart; Heart Rate; India; Infant; Infant Mortality; Light; Live Birth; Mechanics; Monitor; Neonatal; Newborn Infant; Positioning Attribute; Power Sources; Protocols documentation; Research Personnel; Resuscitation; Rural; Signal Transduction; Suggestion; System; Training; United States; Visual; base; cost; design; infant death; instrument; instrumentation; meetings; neonatal death; neonate; prototype; research clinical testing; sound; stillbirth

DESCRIPTION (provided by applicant): There are 3.7 million neonatal deaths and 2.6 million stillbirths in the world each year, and 98% of these occur in developing countries. Some of these deaths are the result of birth attendants not recognizing that unresponsive neonates at birth are alive and can be resuscitated. The goal of this proposed effort is to develop and evaluate a simple instrument, known as a cardiac annunciator that can be placed on a newborn infant's chest to sense its electrocardiogram and produce a sound and a light flash for each detected heart beat. Such a device can help to confirm that the infant is alive and that resuscitation should be attempted. It can also serve to confirm improvement in heart rate as the resuscitation proceeds. The proposed effort is directed at developing the device including electronics, sensing electrodes, and packaging and then to evaluate the device in clinical facilities domestically and in India. Further engineering improvements of the device will be made based upon these evaluations, and if successful the device could be used in a larger clinical study in the developing world to demonstrate its overall impact on reduction of worldwide infant mortality rates. An investigative team of a biomedical engineer, clinical physiologist in India, and neonatologist will ensure that the developed cardiac annunciator will be designed to meet clinical needs of the developing world as well as follow good engineering practices. PUBLIC HEALTH RELEVANCE: A low-cost device that can be placed on the chest of a newborn infant and indicate each heart beat by a sound and light flash is proposed. The device will be designed to be used by birth attendants in the developing world to indicate that nonresponsive newly born infants are indeed alive and to encourage resuscitation of these infants. Such a device could help to reduce infant mortality, 98% of which occurs in the developing world. Engineering development and clinical evaluation of the device will be done as a part of the proposed effort.

描述（由申请人提供）：每年有370万新生儿死亡，世界上有260万个死产，其中98％发生在发展中国家。这些死亡中的一些是亲生服务员没有意识到出生时没有反应的新生儿的结果，可以复苏。这项提出的努力的目的是开发和评估一种简单的仪器，即一种心脏信号器，可以放在新生婴儿的胸部，以感知其心电图，并为每个检测到的心跳产生声音和光闪光。这样的设备可以帮助确认婴儿还活着，并且应该尝试复苏。随着复苏的进行，它还可以确认心率的改善。提出的工作旨在开发设备，包括电子，传感电极和包装，然后在国内和印度评估临床设施中的设备。将根据这些评估进行进一步的工程改进，如果成功的话，该设备可以在发展中国家的更大临床研究中使用，以证明其对降低全球婴儿死亡率的总体影响。印度一名生物医学工程师，临床生理学家和新生儿医生的调查团队将确保将发达的心脏信号器设计为满足发展中国家的临床需求，并遵循良好的工程实践。 公共卫生相关性：可以放置在新生婴儿胸部的低成本设备，并提出了声音和轻闪光灯的每一个心脏跳动。该设备将被设计为由发展中国家的亲生服务员使用，以表明无反应的新生婴儿确实还活着，并鼓励对这些婴儿的复苏。这种装置可以帮助降低婴儿死亡率，其中98％发生在发展中国家。该设备的工程开发和临床评估将作为拟议工作的一部分进行。