A Low-Cost Cardiac Annunciator to Reduce Stillbirths and Neonatal Deaths

降低死产和新生儿死亡的低成本心脏信号器

• 批准号: 8266953
• 负责人: MICHAEL R NEUMAN
• 金额: $ 10.97万
• 依托单位: MICHIGAN TECHNOLOGICAL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-01 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8266953
• 关键词: Achievement; Area; Biomedical Engineering; Birth; Cardiac; Cessation of life; Charge; Chest; Clinical; Clinical Research; Complex; Country; Detection; Developed Countries; Developing Countries; Development; Device Designs; Devices; Distress; Effectiveness; Electrocardiogram; Electrodes; Electronics; Engineering; Ensure; Environmental air flow; Equipment; Evaluation; Feedback; Goals; Grant; Heart; Heart Rate; India; Infant; Infant Mortality; Light; Live Birth; Mechanics; Monitor; Neonatal; Newborn Infant; Positioning Attribute; Power Sources; Protocols documentation; Research Personnel; Resuscitation; Rural; Signal Transduction; Suggestion; System; Training; United States; Visual; base; cost; design; infant death; instrument; instrumentation; meetings; neonatal death; neonate; prototype; research clinical testing; sound; stillbirth

DESCRIPTION (provided by applicant): There are 3.7 million neonatal deaths and 2.6 million stillbirths in the world each year, and 98% of these occur in developing countries. Some of these deaths are the result of birth attendants not recognizing that unresponsive neonates at birth are alive and can be resuscitated. The goal of this proposed effort is to develop and evaluate a simple instrument, known as a cardiac annunciator that can be placed on a newborn infant's chest to sense its electrocardiogram and produce a sound and a light flash for each detected heart beat. Such a device can help to confirm that the infant is alive and that resuscitation should be attempted. It can also serve to confirm improvement in heart rate as the resuscitation proceeds. The proposed effort is directed at developing the device including electronics, sensing electrodes, and packaging and then to evaluate the device in clinical facilities domestically and in India. Further engineering improvements of the device will be made based upon these evaluations, and if successful the device could be used in a larger clinical study in the developing world to demonstrate its overall impact on reduction of worldwide infant mortality rates. An investigative team of a biomedical engineer, clinical physiologist in India, and neonatologist will ensure that the developed cardiac annunciator will be designed to meet clinical needs of the developing world as well as follow good engineering practices. PUBLIC HEALTH RELEVANCE: A low-cost device that can be placed on the chest of a newborn infant and indicate each heart beat by a sound and light flash is proposed. The device will be designed to be used by birth attendants in the developing world to indicate that nonresponsive newly born infants are indeed alive and to encourage resuscitation of these infants. Such a device could help to reduce infant mortality, 98% of which occurs in the developing world. Engineering development and clinical evaluation of the device will be done as a part of the proposed effort.

描述（申请人提供）：全球每年有 370 万新生儿死亡和 260 万死产，其中 98% 发生在发展中国家。其中一些死亡是由于接生员没有认识到出生时反应迟钝的新生儿还活着并且可以复苏的结果。这项工作的目标是开发和评估一种简单的仪器，称为心脏信号器，可以放置在新生儿的胸部来感知其心电图，并在每次检测到的心跳时发出声音和闪光。这样的设备可以帮助确认婴儿还活着并且应该尝试复苏。它还可以用来确认随着复苏的进行心率的改善。拟议的工作旨在开发该设备，包括电子设备、传感电极和包装，然后在国内和印度的临床设施中评估该设备。将根据这些评估对该设备进行进一步的工程改进，如果成功，该设备可以用于发展中国家的更大规模的临床研究，以证明其对降低全球婴儿死亡率的总体影响。由生物医学工程师、印度临床生理学家和新生儿学家组成的研究小组将确保开发的心脏信号器的设计能够满足发展中国家的临床需求，并遵循良好的工程实践。 公共健康相关性：提出了一种低成本设备，可以放置在新生婴儿的胸部，并通过声音和闪光来指示每次心跳。该设备将设计供发展中国家的助产士使用，以表明无反应的新生儿确实还活着，并鼓励对这些婴儿进行复苏。这种设备可以帮助降低婴儿死亡率，其中 98% 的婴儿死亡率发生在发展中国家。该设备的工程开发和临床评估将作为拟议工作的一部分进行。