Self-Injurious Behavior and Primate Well-being

自残行为和灵长类动物的福祉

• 批准号: 8496890
• 负责人: Melinda Ann Novak
• 金额: $ 66.51万
• 依托单位: UNIVERSITY OF MASSACHUSETTS AMHERST
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-30 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8496890
• 关键词: Adolescent; Adult; Aftercare; Alopecia; Animal Experimentation; Animals; Anxiety; Arousal; Atopic Dermatitis; Behavior; Behavioral; Bite; Development; Disease; Disease remission; Effectiveness; Euthanasia; Event; Failure; Goals; Hair; Housing; Human; Human Resources; Hypothalamic structure; Incidence; Infant; Knowledge; Laboratories; Life; Light; Longitudinal Studies; Macaca; Macaca mulatta; Maintenance; Modeling; Monkeys; Naltrexone; New England; Opioid Receptor; Outcome; Patients; Personal Satisfaction; Pharmaceutical Preparations; Pharmacological Treatment; Physiological; Pituitary Gland; Practice Management; Precipitating Factors; Prevalence; Prevention; Prevention strategy; Primates; Procedures; Protocols documentation; Relapse; Reporting; Research; Resistance; Resources; Risk; Risk Factors; Role; Self-Injurious Behavior; Severities; Stress; Stressful Event; Symptoms; System; Testing; base; cost effective; design; environmental enrichment for laboratory animals; human disease; improved; model development; neurochemistry; nonhuman primate; novel; novel therapeutic intervention; prevent; social; social separation; treatment duration

DESCRIPTION (provided by applicant): The presence of severely abnormal behavior, such as self-injurious behavior (SIB) in laboratory housed primates compromises the quality of the animal research resource and adversely impacts research. In rhesus monkeys, SIB consists of intense, self-directed biting that can result in serious wounds requiring veterinary treatment. Based on findings from our laboratory and others, we have developed a model proposing that SIB arises from adverse life events, is maintained by dysregulation of several neurochemical and physiological systems, and functions to reduce anxiety. Unfortunately, SIB is resistant to treatment, alleviated neither by environmental enrichment nor changes in cage size. Pharmacological treatments have shown effectiveness in reducing SIB; however, relapse is common post-treatment, and long-term maintenance on drugs is undesirable for research purposes. The long-term goal of this project is to decrease the prevalence of SIB in captive primates by (1) preventing the onset of SIB through identification of key risk factors, and (2) developing novel treatments for this disorder that are cost-effective and produce long-lasting benefit. In furtherance of this goal, the proposed project will test the hypothesis that stress exposure and anxious behavior are precipitating factors in the development of SIB. To determine the generality of this hypothesis, factors contributing to SIB onset will be studied at 4 national primate research centers. To reduce the incidence of SIB in animals that have already developed this disorder, we will test a novel pharmacotherapeutic approach involving administration of the opioid receptor antagonist naltrexone. Short- term treatment with naltrexone has been shown to yield long-term decrements in SIB in many human patients, but this compound has not yet been tested on non-human primates. Finally, hair plucking (another type of SIB) and more generally hair loss have come under increased scrutiny from federal regulators. Consequently, we have enlarged the scope of this project to include hair loss, and we will test the hypothesis that hair loss in captive primates can result from several different factors, including hair plucking, stress and anxiety, and atopic dermatitis.

描述（由申请人提供）：存在严重异常行为，例如实验室内部灵长类动物中的自我伤害行为（SIB）损害了动物研究资源的质量，并对研究产生了不利影响。在恒河猴中，SIB由强烈的，自我指导的咬人组成，可能会导致严重的伤口需要兽医治疗。根据我们的实验室和其他人的发现，我们开发了一个模型，该模型提出SIB是由不良生活事件引起的，该模型通过几种神经化学和生理系统的失调来维持，以及减少焦虑的功能。不幸的是，SIB对治疗有抵抗力，既不是由于环境富集而减轻的，也没有笼子大小的变化。药理治疗表明在减少SIB方面有效。但是，复发是常见的治疗后，对药物的长期维持是不可能的。该项目的长期目标是通过（1）通过鉴定关键危险因素来防止SIB发作，以及（2）为这种疾病开发新颖的治疗方法，这些疾病具有成本效益并产生持久的好处。为了促进这一目标，拟议的项目将检验以下假设：压力暴露和焦虑行为是SIB发展的促成因素。为了确定这一假设的一般性，将在4个国家灵长类动物研究中心研究导致SIB发作的因素。为了减少已经患有这种疾病的动物中SIB的发生率，我们将测试一种新型的药物治疗方法，涉及给予阿片受体拮抗剂纳曲酮。已经证明，用纳曲酮的短期治疗在许多人类患者中可以长期减少SIB，但是该化合物尚未对非人类灵长类动物进行测试。最后，摘发（另一种类型的SIB）和更普遍的脱发受到了联邦监管机构的审查。因此，我们扩大了该项目的范围以包括脱发，我们将检验以下假设：圈养灵长类动物的脱发可能是由于几种不同的因素引起的，包括拔毛，压力和焦虑以及特应性皮炎。