MCCTR/UMMC Year4 N3C Grant Initiative

MCCTR/UMMC Year4 N3C 资助计划

• 批准号: 10887860
• 负责人: Joey P. Granger
• 金额: $ 26.77万
• 依托单位: UNIVERSITY OF MISSISSIPPI MED CTR
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-18 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10887860
• 关键词: Academic Medical Centers; Address; Adult; Advisory Committees; African American population; Alabama; Area; Behavior Therapy; Biomedical Research; Biometry; Black race; Cardiometabolic Disease; Cardiovascular Diseases; Cause of Death; Center for Translational Science Activities; Cessation of life; Child; Clinic; Clinical; Clinical Research; Clinical Sciences; Cohort Studies; Collaborations; Communicable Diseases; Communication; Communities; Community Outreach; Data Collection; Development; Diabetes Mellitus; Diagnosis; Disease; Disparity; Effectiveness; Epidemiology; Evaluation; Extramural Activities; Faculty; Fostering; Foundations; Funding; Goals; Grant; Growth; Health; Health Disparities Research; Health Personnel; Health Services Accessibility; Human Resources; Income; Infant Mortality; Infrastructure; Institution; Interdisciplinary Study; Leadership; Louisiana; Low Birth Weight Infant; Marketing; Medical center; Mentors; Mentorship; Mississippi; Modernization; National Institute of General Medical Sciences; Obesity; Obesity associated disease; Office of Administrative Management; Outcome; Outreach Research; Performance; Persons; Phase; Pilot Projects; Population; Population Research; Poverty; Research; Research Design; Research Personnel; Research Project Grants; Research Support; Resources; Rural; Rural Community; Rural Health; Scientist; Services; Statistical Data Interpretation; Structure; Telemedicine; Time; Training; Translational Research; Universities; Urban Community; Work; cardiometabolism; clinical care; clinical center; clinical implementation; college; community engaged research; community engagement; data management; data warehouse; economic disparity; electronic data; ethnic health disparity; health disparity; implementation research; implementation science; improved; innovation; member; multidisciplinary; outreach; physical inactivity; practice-based research network; programs; racial disparity; racial health disparity; recruit; rural disparities; statistics; success; telehealth; tool; training opportunity; translational engagement; translational research program

PROJECT SUMMARY. Mississippi has some of the nation's worst health outcomes and was ranked by the United Health Foundation as the “least healthy state” in 2019. Further, the racial disparities surrounding these health outcomes are profound. The complexities associated with effectively addressing Mississippians' health outcomes and ameliorating Mississippi's health disparities necessitate a strong, multi-disciplinary research and outreach infrastructure. The Mississippi Center for Clinical and Translational Research (MCCTR) was established in 2016 to provide this infrastructure, equipping researchers with the resources needed to conduct clinical, translational, and population-based research projects. The MCCTR proposes to continue and expand its efforts through what it has termed as “Phase II.” In Phase II, the MCCTR will add two new institutional partners, Mississippi State University and University of Mississippi-Oxford, to its Phase I partners, University of Mississippi Medical Center, Tougaloo College, and University of Southern Mississippi. It will also add two CTR/CTSAs as collaborating partners, the University of Alabama at Birmingham's Center for Clinical and Translational Science and the Northwestern University Clinical and Translational Sciences, to its Phase I partners: Mayo Clinic's Center for Clinical and Translational Science and the Louisiana Clinical and Translational Science Center. The Administrative Core will be responsible for managing the administrative, fiscal, and scientific aspects of the MCCTR, including the oversight, marketing, and coordination of all MCCTR cores and activities. The Professional Development Core will offer structured mentorship, training opportunities, and protected research time for early stage investigators at MCCTR partner institutions. The Community Engagement and Outreach Core will provide training and support to investigators in conducting community engaged research; partner with healthcare providers through its new Practice-Based Research Network; and work with its expanded Community Advisory Board to provide bi-directional communication and guidance on community values, concerns, and needs and represent the MCCTR to Mississippi Communities. The Biostatistics, Epidemiology, and Research Design Core will provide training and assistance with research design, data collection and management, and statistical analysis to increase the effectiveness, efficiency, and success of research conducted by MCCTR investigators. The Pilot Projects Program will support clinical, translational, and population-based research projects likely to have a meaningful impact on Mississippi health outcomes and lead to extramural funding. The Research Services Core will support research projects through study coordination and regulatory support and will help connect researchers to communities through expanded telehealth and cohort-study resources. Finally, the Tracking and Evaluation Core will provide accurate and timely information on MCCTR performance and impact to inform planning and implementation by leadership and advisory bodies. Through the infrastructure of resources and personnel developed by MCCTR, Mississippi's health outcomes will be positively impacted.

项目摘要。密西西比州的健康状况是全美最差的，并被评为 联合健康基金会被评为 2019 年“最不健康的州”。此外，围绕这些州的种族差异 有效解决密西西比人的健康问题具有深远的影响。 成果和改善密西西比州的健康差距需要强有力的、多学科的研究和 密西西比临床和转化研究中心 (MCCTR) 是外展基础设施。 于 2016 年成立，旨在提供这一基础设施，为研究人员提供开展研究所需的资源 MCCTR 建议继续并扩大临床、转化和基于人群的研究项目。 在第二阶段，MCCTR 将增加两个新的机构合作伙伴， 密西西比州立大学和密西西比大学牛津分校致第一阶段合作伙伴密西西比大学 医疗中心、Tougaloo 学院和南密西西比大学还将增加两个 CTR/CTSA。 合作伙伴：阿拉巴马大学伯明翰分校临床和转化科学中心 和西北大学临床与转化科学，致其一期合作伙伴：梅奥诊所中心 临床和转化科学以及路易斯安那州临床和转化科学中心。 行政核心将负责管理行政、财政和科学方面 MCCTR，包括所有 MCCTR 核心和活动的监督、营销和协调。 专业发展核心将提供结构化指导、培训机会和受保护的研究 MCCTR 合作机构的早期研究人员有时间参与社区参与和外展活动。 Core 将为研究人员提供培训和支持，以与合作伙伴开展社区参与研究； 医疗保健提供者通过其新的基于实践的研究网络；并与其扩展的社区合作； 咨询委员会就社区价值观、关注点和问题提供双向沟通和指导 需求并代表 MCCTR 向密西西比社区提供生物统计学、流行病学和研究服务。 设计核心将提供研究设计、数据收集和管理方面的培训和帮助，以及 统计分析，以提高 MCCTR 所进行研究的有效性、效率和成功率 试点项目计划将支持临床、转化和基于人群的研究。 项目可能对密西西比州的健康成果产生有意义的影响，并带来外部资金。 研究服务核心将通过研究协调和监管支持来支持研究项目 将通过扩大远程医疗和队列研究资源帮助研究人员与社区建立联系。 跟踪和评估核心将提供有关 MCCTR 绩效的准确和及时的信息 通过基础设施为领导和咨询机构的规划和实施提供影响。 MCCTR 开发的资源和人员，密西西比州的健康成果将受到积极影响。

项目成果

Primary Aldosteronism: KCNJ5 Mutations and Adrenocortical Cell Growth.

原发性醛固酮增多症：KCNJ5 突变和肾上腺皮质细胞生长。

• 发表时间: 2019
• 作者: Yang, Yuhong;Gomez;Jaquin, Diana;Aristizabal Prada, Elke Tatjana;Meyer, Lucie S;Knösel, Thomas;Schneider, Holger;Beuschlein, Feli;Reincke, Martin;Williams, Tracy Ann
• 通讯作者: Williams, Tracy Ann

Association of Change in N-Terminal Pro-B-Type Natriuretic Peptide Following Initiation of Sacubitril-Valsartan Treatment With Cardiac Structure and Function in Patients With Heart Failure With Reduced Ejection Fraction.

射血分数降低的心力衰竭患者开始沙库巴曲缬沙坦治疗后 N 端 B 型利钠肽的变化与心脏结构和功能的关联。

• 发表时间: 2019-09-17
• 作者: Januzzi Jr, James L;Prescott, Margaret F;Butler, Javed;Felker, G Michael;Maisel, Alan S;McCague, Kevin;Camacho, Alexander;Piña, Ileana L;Rocha, Ricardo A;Shah, Amil M;Williamson, Kristin M;Solomon, Scott D;PROVE
• 通讯作者: PROVE

Influence of the Fear of Missing Out in Student Pharmacists' Decision to Pursue Residency Training.

害怕错过的恐惧对学生药剂师决定接受住院医师培训的影响。

• 发表时间: 2019-09
• 影响因子: 3.3
• 作者: Crumby, Ashley S;Bouldin, Alicia S;Rosenthal, Meagen M;Bentley, John P;Gregory, David F
• 通讯作者: Gregory, David F

Leadership Gender Disparity Within Research-Intensive Medical Schools: A Transcontinental Thematic Analysis.

研究密集型医学院内的领导性别差异：跨大陆专题分析。

• 发表时间: 2019
• 作者: Abdellatif, Waleed;Ding, Jeffrey;Jalal, Sabeena;Chopra, Sanjiv;Butler, Javed;Ali, Ismail Tawakol;Shah, Samad;Khosa, Faisal
• 通讯作者: Khosa, Faisal

Impact of Autonomic Regulation Therapy in Patients with Heart Failure: ANTHEM-HFrEF Pivotal Study Design.

自主调节治疗对心力衰竭患者的影响：ANTHEM-HFrEF 关键研究设计。

• 发表时间: 2019
• 作者: Konstam, Marvin A;Udelson, James E;Butler, Javed;Klein, Helmut U;Parker, John D;Teerlink, John R;Wedge, Patricia M;Saville, Benjamin R;Ardell, Jeffrey L;Libbus, Imad;DiCarlo, Lorenzo A
• 通讯作者: DiCarlo, Lorenzo A