Core 1 - Pediatric Rheumatology Tissue Repository Core

核心 1 - 儿科风湿病组织存储库核心

• 批准号: 8209376
• 负责人: SUSAN D THOMPSON
• 金额: $ 18.6万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8209376
• 关键词: Biological; Biological Markers; Blood; Childhood; Classification; Clinical; Collection; Computer software; Consent; Consumer Advocates in Research and Related Activities; DNA; Databases; Development; Disease; Documentation; Ensure; Funding; Future; Genetic; Genomics; Hair; Housing; Human Resources; Immunologics; Informatics; Institution; Institutional Review Boards; International; Lymphocyte; Muscle; Musculoskeletal; Patients; Peripheral Blood Lymphocyte; Peripheral Blood Mononuclear Cell; Plasma; Population Research; Process; Proteins; Proteomics; Protocols documentation; RNA; Relative (related person); Research; Research Personnel; Research Project Grants; Resources; Rheumatism; Rheumatology; Saliva; Sampling; Savings; Shipping; Ships; Site; Software Design; Solutions; Source; Specimen; Study of serum; Synovial Fluid; System; Tissues; Training; Translational Research; United States National Institutes of Health; Urine; Vision; Whole Blood; base; biomedical informatics; clinical research site; commercial application; immortalized cell; meetings; open source; repository; rheumatologist; sample collection; translational study

The Pediatric Rheumatology Tissue Repository (PRTR), a funded component of a PSO rheumatic disease core center, assists local and national investigators in specimen collection, processing, storage and distribution of biospecimens for rheumatic diseases-related studies. The principal functions of this core are: ¿ To collect, process and maintain biological specimens from patients with pediatric rheumatological and related musculoskeletal conditions as well as from relevant control populations for research purposes. Samples collected include blood, urine, synovial fluid, synovial tissue, hair and saliva. Products derived from these collections are suitable for genetic, genomic, proteomic, immunologic function and biomarker studies. ¿ To optimize the availability and potential for use of sample collections. Collection, processing and storage practices are optimized to meet current and future study needs and when possible standardized to be consistent with other national and international efforts. ¿ To provide high quality samples in an appropriate format for investigators conducting IRB-approved basic and translational studies in pediatric rheumatologic disease. Informatics solutions for sample storage documentation will allow accurate and appropriate use. Current systems have been optimized to allow information relative to consent, source of collection (study, extemal site, type of sample, etc), and specifics of handling/processing as well as prior use to be considered when accessing samples. Established practices of the PRTR for sample collection, processing shipping and training of clinical site personnel ensure that the scope of specimens needed for translational research projects are available. Thus, this unique resource is important to enabling definitive genomic and biological studies necessary to understand and define childhood rheumatic diseases.

儿科风湿病组织存储库 (PRTR) 是 PSO 风湿病核心中心的资助组成部分，协助地方和国家研究人员收集、处理、储存和分发用于风湿病相关研究的生物样本。 该核心的主要功能是： ¿收集、处理和保存儿科风湿病和相关肌肉骨骼疾病患者以及相关对照人群的生物样本，用于研究目的。收集的样本包括血液、尿液、滑液、滑液组织、头发和唾液。 来自这些集合的产品适用于遗传、基因组、蛋白质组、免疫功能和生物标志物研究。 ¿为了优化样本收集的可用性和使用潜力，优化收集、处理和存储实践，以满足当前和未来的研究需求，并在可能的情况下进行标准化，以与其他国家和国际工作保持一致。 ¿为了以适当的格式为研究人员提供经 IRB 批准的儿科风湿病基础和转化研究，样本存储文档的信息学解决方案将允许准确和适当的使用当前的系统，以允许与同意、来源相关的信息。收集的方式（研究、外部地点、样本类型等）、处理/加工的细节以及获取样本时要考虑的事先使用情况。 PRTR 在样本采集、处理运输和临床现场人员培训方面的既定实践确保了转化研究项目所需样本的范围可用，因此，这一独特的资源对于实现理解和定义所需的明确基因组和生物学研究非常重要。儿童风湿病。