PEDIATRIC RHEUMATOLOGY TISSUE REPOSITORY

儿科风湿病组织库

• 批准号: 7475901
• 负责人: SUSAN D THOMPSON
• 金额: $ 7.72万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7475901
• 关键词: Appendix; Biological; Childhood; Classification; Clinical; Collection; Computer software; Condition; Consent; DNA; Disease; Ensure; Genetic; Human Herpesvirus 4; Human Resources; Institution; Liquid substance; Lymphocyte; Muscle; Musculoskeletal; Online Systems; Pamphlets; Patients; Peripheral Blood Lymphocyte; Peripheral Blood Mononuclear Cell; Plasma; Population Research; Process; Protocols documentation; Purpose; RNA; Research; Research Ethics Committees; Research Personnel; Research Project Grants; Resources; Rheumatology; Sampling; Serum; Shipping; Ships; Site; Specimen; Synovial Fluid; Tissues; Training; Translational Research; Whole Blood; base; biomedical informatics; clinical research site; immortalized cell; repository; sample collection; translational study

A Pediatric Rheumatology Tissue Repository (PRTR) is a proposed resource available to investigators of the research base, as well as at the national level for multi-center studies in pediatric rheumatology. This repository provides uniform acquisition and storage of patient and control samples for research purposes. In addition, training is provided to outside centers to ensure smooth and consistent functioning in collection. The principal functions of this Core are: To collect, process and maintain biological specimens from patients with pediatric rheumatological and related musculoskeletal conditions as well as from relevant control populations for research purposes. The types of samples currently primarily include RNA, DNA, synovial fluid, synovial tissue, serum and lymphocytes; To support multi-center collection of patient and control samples nationally. The scope of specimens needed for translational research projects is extensive and can rarely be accomplished without collaborative efforts between multiple clinical investigative sites. The PRTR will assist in establishing sample collection, processing and shipping protocols and coordinate training of clinical site personnel to provide uniform sample collection. The function has been extended beyond the local research base to pediatric rheumatologists at other institutions; To allow systematic access to biological samples for investigators conducting IRB approved basic and translational studies in pediatric rheumatological disease and provide specimens to investigators in appropriate format. This will be done by tracking specimens, study information, consent information and necessary clinical classification within the Biomedical Informatics managed, web-based Biorepository (BR) and integrated Protocol Manager (PM) Software modules.

儿科风湿病组织存储库 (PRTR) 是一项可供研究人员使用的拟议资源 的研究基地，以及国家级小儿风湿病多中心研究。 该存储库提供患者和对照样本的统一采集和存储以供研究 目的。此外，还向外部中心提供培训，以确保顺利和一致 在集合中发挥作用。 该核心的主要功能是： 收集、处理和保存患有儿科风湿病和相关肌肉骨骼疾病的患者以及相关对照人群的生物样本，用于研究目的。目前样本类型主要包括RNA、DNA、滑液、滑膜组织、 血清和淋巴细胞； 支持全国范围内患者和对照样本的多中心采集。范围 转化研究项目所需的样本非常广泛且很少能够完成 无需多个临床研究中心之间的协作努力。 PRTR 将协助 建立样本采集、处理和运输协议并协调临床现场培训 人员提供统一的样品采集。功能已经扩展到本地之外 其他机构儿科风湿病专家的研究基地； 允许研究人员系统地获取生物样本，以进行 IRB 批准的儿科风湿病基础和转化研究，并以适当的格式向研究人员提供标本。这将通过在生物医学信息学管理的基于网络的系统中跟踪样本、研究信息、同意信息和必要的临床分类来完成 生物样本库 (BR) 和集成协议管理器 (PM) 软件模块。