Cincinnati Rheumatic Diseases Resource Center

辛辛那提风湿病资源中心

基本信息

批准号：
9788028
负责人：
SUSAN D THOMPSON
金额：
$ 78.11万
依托单位：
CINCINNATI CHILDRENS HOSP MED CTR
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-08-01 至 2021-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9788028
关键词：
Adult Area Autoimmune Process Basic Science Bioinformatics Biomedical Research Caring Categories Cells Cellular biology Child Childhood Chronic Childhood Arthritis Clinical Trials Clinical Trials Design Collaborations Communities Comorbidity Development Disease Doctor of Philosophy Educational workshop Etiology Feasibility Studies Fostering Functional disorder Funding Opportunities Genetic Genomics Goals Health Immunobiology Inflammatory Informatics Infrastructure Investments Knowledge Laboratories Laboratory Finding Lead Medical Medical center Medicine Modeling Modification Molecular Biology Morbidity - disease rate Outcome Outcome Measure Pathogenicity Pathology Patient Care Patients Pediatric Hospitals Pharmacology Phenotype Pilot Projects Plant Roots Positioning Attribute Process Reporting Research Research Personnel Resources Rheumatism Rheumatology Services Societies Systemic Lupus Erythematosus Tissues Transcend Translating Translational Research United States National Institutes of Health Universities base career clinical care clinical practice college cost experience falls functional genomics innovation insight interdisciplinary approach interdisciplinary collaboration news novel therapeutics patient oriented patient oriented research pediatric patients pediatric rheumatic diseases programs ranpirnase recruit repository symposium tool translational study

项目摘要

The overall goal of the Cincinnati Rheumatic Diseases Resource Center (CRDRC) is to promote biomedical research that yields insights into fundamental processes and pathogenic mechanisms of rheumatic diseases in children, which can lead to innovative treatments for these diseases. The aims of the CRDRC are to 1) to provide resources that enhance the scope and breadth of the overall research community to advance the understanding of pediatric rheumatic disease and 2) to foster collaborations and interdisciplinary approaches to promote laboratory discoveries, generate translational research opportunities that ultimately impact patient care. The CRDRC will support projects with potential to advance the national research agenda related to rheumatic diseases, and that represent an area of tremendous strength and resource investment at Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine. The CRDRC will offer four innovative research-based resources, including a Pediatric Rheumatology Tissue Repository, a Single Cell Phenotyping Core, a Functional Genomics Core and a Rheumatology Informatics Core. Collectively, these resources form a powerful infrastructure that fosters development of precision and predictive medical approaches based on genomics and disease mechanisms. The CRDRC will support disease-based research across the continuum of discovery, where laboratory findings generate translational studies that lead to clinical trials. In addition to advancing knowledge of pediatric rheumatic disease, the goals of the CRDRC include recruitment of established investigators to bring new expertise to the field, cultivation of collaborations within the local and national research community, and encouragement of young investigators committed to pursuing research careers focused on pediatric rheumatic disease. These goals of the CRDRC are particularly well supported by a Pilot & Feasibility Study Program that will transcend the Cincinnati research community to include pediatric rheumatology investigators across the US. The CRDRC also will strengthen the research community through an enrichment program of local seminars, workshops and symposia. A highly accomplished and collaborative community of researchers is already in place creating fertile ground for accomplishing the goals of the Cincinnati Center, and ultimately to accelerate research to benefit pediatric rheumatic disease patients in their care.

辛辛那提风湿病资源中心 (CDRRC) 的总体目标是促进生物医学深入了解风湿病的基本过程和致病机制的研究儿童，这可以为这些疾病带来创新的治疗方法。 CDRRC 的目标是 1) 提供资源，扩大整个研究界的范围和广度，以推进了解儿科风湿病，2) 促进合作和跨学科方法促进实验室发现，产生最终影响患者的转化研究机会关心。 CDRRC 将支持有潜力推进国家研究议程的项目风湿性疾病，这代表了辛辛那提大学拥有巨大实力和资源投资的领域儿童医院医疗中心和辛辛那提大学医学院。 CDRRC将提供四个基于研究的创新资源，包括儿科风湿病组织存储库、单细胞表型核心、功能基因组学核心和风湿病信息学核心。总的来说，这些资源形成强大的基础设施，促进精准和预测医疗的发展基于基因组学和疾病机制的方法。 CDRRC 将支持基于疾病的研究在整个发现过程中，实验室发现产生转化研究，从而导致临床试验。除了增进儿科风湿病知识外，CDRRC 的目标还包括招募现有的调查员，为该领域带来新的专业知识，培养内部合作地方和国家研究界，并鼓励年轻的研究人员致力于追求研究生涯专注于小儿风湿病。 CDRRC 的这些目标特别好由试点和可行性研究计划支持，该计划将超越辛辛那提研究界包括美国各地的儿科风湿病研究人员。 CDRRC也将加强研究通过当地研讨会、讲习班和座谈会等丰富计划，与社区开展交流。一个高度成熟的研究人员协作社区已经就位，为以下领域创造了肥沃的土壤：实现辛辛那提中心的目标，并最终加速研究，造福儿科风湿病患者在他们的照顾下。