Imaging Core

成像核心

• 批准号: 8187075
• 负责人: Felix W Wehrli
• 金额: $ 19.45万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8187075
• 关键词: Address; Advanced Development; Animal Disease Models; Animal Diseases; Animal Model; Animals; Basic Science; Biochemical; Biological Assay; Clinic; Clinical; Collaborations; Data; Degenerative Disorder; Degenerative polyarthritis; Detection; Development; Disease; Disease Progression; Environment; Evaluation; Faculty; Fracture; Funding; Housing; Human; Image; Imaging Techniques; Imaging technology; Injury; Instruction; Intervention; Knock-out; Laboratory Animals; Longitudinal Studies; Magnetic Resonance Imaging; Measurement; Mechanics; Methods; Modality; Molecular; Monitor; Mus; Musculoskeletal; Musculoskeletal Diseases; Musculoskeletal System; Osteoporosis; Pennsylvania; Physiological; Physiology; Process; Radiology Specialty; Rattus; Research; Research Personnel; Resources; Scientist; Structure; Technology; Therapeutic; Time; Tissue Extracts; Tissues; Transgenic Organisms; Translational Research; Universities; cost; genome sequencing; human disease; imaging modality; immunosuppressed; in vivo; injury and repair; innovation; molecular imaging; molecular marker; musculoskeletal imaging; musculoskeletal injury; novel; programs; research study; response; tool

Imaging is a critically important technology for clinical, translational, cadaveric, and in vivo studies of animal and human disease. Whether the ability to characterize tissue structure or visualize molecular markers in a non-invasive manner, advanced imaging methods have proven to be powerful tools specifically for musculoskeletal applications. Research employing imaging that addresses problems in musculoskeletal injury and repair in humans has a long track record. Further, imaging is recognized to be vital as new evaluation and treatment modalities are developed and used for some of the major degenerative disorders such as osteoporosis and osteoarthritis or traumatic injuries such as fractures. The University of Pennsylvania has one of the most comprehensive imaging facilities in the nation, comprised of a complete range of imaging modalities dedicated to basic and translational research in animals and humans. Moreover, it is staffed by some of the leading scientists in the various imaging modalities. A key objective of the Penn Center for Musculoskeletal Disorders therefore is to provide an on-campus Imaging Core (IC) to musculoskeletal researchers for imaging of both humans and large and small animals. The overall objective of the IC is to develop and utilize a wide range of imaging techniques directed toward problems of musculoskeletal tissue injury and repair. The Specific Aims are: Aim 1: To provide guidance and expertise on the use of imaging for musculoskeletal research through educational enrichment programs and one-on one interactions. Aim 2: To provide a range of imaging resources for the study of structure, function and physiology of the musculoskeletal system in laboratory animals and humans. Aim 3: To provide pilot funding for development of new projects and collaborations and for investigators to generate preliminary data.

成像是对动物和人类疾病的临床，转化，尸体和体内研究的至关重要的技术。无论是以非侵入性的方式表征组织结构的能力还是可视化分子标记，先进的成像方法已被证明是专门针对肌肉骨骼应用的强大工具。采用成像的研究解决了人类肌肉骨骼损伤和修复的问题，具有很长的记录。此外，由于开发了新的评估和治疗方式，因此成像被认为是至关重要的，并将其用于一些主要的退化性疾病，例如骨质疏松症和骨关节炎或骨折等创伤性损伤。宾夕法尼亚大学拥有全国最全面的成像设施之一，包括专门针对动物和人类基础和翻译研究的一系列成像方式。此外，它由各种成像方式的一些主要科学家组成。因此，宾夕法尼亚州肌肉骨骼疾病中心的一个关键目标是为校园成像核心（IC）提供肌肉骨骼研究人员，以对人类和大型动物进行成像。 IC的总体目标是开发和利用针对肌肉骨骼组织损伤和修复问题的广泛的成像技术。具体目的是：目标1：通过教育丰富计划和一对一的相互作用提供有关将成像用于肌肉骨骼研究的指导和专业知识。目标2：提供一系列成像资源，以研究实验动物和人类中肌肉骨骼系统的结构，功能和生理学的研究。目标3：为开发新项目和合作的开发提供试点资金，并使调查人员生成初步数据。