Core C: Radiosensitization Core

核心 C：放射增敏核心

• 批准号: 10554477
• 负责人: Alnawaz Rehemtulla
• 金额: $ 12.12万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-14 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10554477
• 关键词: Address; Animal Model; Animals; Biological Models; Bioluminescence; Biometry; Cancer Center; Cancer Model; Cancer Therapy Evaluation Program; Cell model; Cells; Clinical; Clinical Trials; Combined Modality Therapy; Computational Biology; Computer Analysis; Consensus; Cultured Cells; DNA Repair; Development; Developmental Therapeutics Program; Discipline; Disease; Dose; Drug Kinetics; Ensure; Evaluation; Goals; Human; Image; In Vitro; Knowledge; Lasers; Lead; Locally Advanced Malignant Neoplasm; Malignant Neoplasms; Medical; Michigan; Modeling; Molecular Target; Monitor; Pathology; Patients; Pharmaceutical Preparations; Pharmacodynamics; Pharmacology; Physics; Pre-Clinical Model; Procedures; Radiation; Radiation Oncology; Radiation Physics; Radiation therapy; Radiation-Sensitizing Agents; Radiosensitization; Research; Research Activity; Research Personnel; Research Project Grants; Resource Sharing; Resources; Schedule; Services; Technology; Testing; Therapeutic; Therapeutic Agents; Therapeutic Equivalency; Translating; Translations; Treatment Efficacy; Tumor Burden; Universities; Work; clinical practice; design; experience; image guided; image guided radiation therapy; improved; in vivo; insight; instrument; instrumentation; irradiation; molecular imaging; mouse model; pre-clinical; preclinical imaging; preclinical study; professor; programs; radiation delivery; subcutaneous; success; targeted agent; therapeutic evaluation; therapy development; treatment planning; treatment response; tumor

PROJECT SUMMARY/ABSTRACT (Radiosensitization Core) The Radiosensitization Core within this SPORE will provide specialized expertise, instrumentation and technical services to each of the Projects for their research activities related to evaluation of radiation sensitization of therapeutic agents. These services include irradiation of cultured cells and animal models, development of treatment plans for conformal irradiation of subcutaneous and orthotopic tumors, evaluation of therapeutic response using imaging with the goal of optimizing dose and schedule of the combination therapies in a rational and mechanism driven manner. The Core features three orthovoltage units, a SARRP (Small Animal Radiation Research Platform) which permits bioluminescence and CT-guided delivery of radiation to animals as well a laser microirradiation instrument to study DNA repair in single cells. Additionally, the Radiosensitization Core will be a central conduit for SPORE investigators to access research resources within the Rogel Cancer Center, including the Pharmacokinetics Shared Resource and the Preclinical Imaging and Computational Analysis Shared Resource. Dr. Balter, will oversee activities related to image-guided radiation therapy and conformal treatment planning. Dr. Rehemtulla, will guide studies on mouse models of cancer and imaging to provide quantitative and mechanistic insights for each of the project-specific therapeutic paradigms. Dr. Leopold will oversee research related to preclinical optimization of dosing and schedule for test agents in a manner that informs design of the planned clinical trials in each project. The Radiosensitization Core will also work seamlessly with the other Cores within the SPORE, the Biostatistics and Computational Biology Core and the Translational Pathology Core, to ensure that the planning and execution of pre-clinical studies is conducted with scientific rigor and consistent with the goals of each of the projects. The integration of the Radiosensitization core with each of the research Projects and the Cores is critical and will provide SPORE investigators the ability to conduct studies that positively impact the management of patients undergoing radiation therapy.

项目摘要/摘要（放射增敏核心） SPORE 内的放射增敏核心将提供专业知识、仪器和 为每个项目的与辐射评估相关的研究活动提供技术服务 治疗剂的致敏。这些服务包括培养细胞和动物模型的辐照， 制定皮下和原位肿瘤适形照射的治疗计划，评估 使用成像的治疗反应，目的是优化联合疗法的剂量和时间表 理性、机制驱动。该核心具有三个正电压单元、一个 SARRP（小型 动物辐射研究平台）允许生物发光和 CT 引导的辐射传递 动物以及用于研究单细胞 DNA 修复的激光微辐照仪器。此外， 放射增敏核心将成为 SPORE 研究人员获取研究资源的中心渠道 罗格尔癌症中心，包括药代动力学共享资源和临床前成像和 计算分析共享资源。巴尔特博士将监督与图像引导辐射相关的活动 治疗和适形治疗计划。 Rehemtulla 博士将指导小鼠癌症模型和 成像为每个项目特定的治疗范例提供定量和机制的见解。 Leopold 博士将监督与临床前试验药物剂量和时间表优化相关的研究 为每个项目中计划的临床试验的设计提供信息的方式。放射增敏核心还将 与 SPORE 中的其他核心、生物统计学和计算生物学核心以及 转化病理学核心，确保临床前研究的规划和执行 具有科学严谨性并与每个项目的目标一致。的整合 每个研究项目和核心的放射增敏核心至关重要，将提供 SPORE 研究人员有能力进行对接受治疗的患者的管理产生积极影响的研究 放射治疗。