2/4 Powering Genetic Discovery for Severe Mental Illness in Latin American and African Ancestries

2/4 推动拉丁美洲和非洲血统中严重精神疾病的基因发现

• 批准号: 10818056
• 负责人: KARESTAN C KOENEN
• 金额: $ 12.39万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-18 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10818056
• 关键词: Acceleration; Administrative Supplement; African; African ancestry; Anhedonia; Asian; Bipolar Disorder; Cognition; Communities; Consensus; Country; Data; Data Analyses; Data Analytics; Data Collection; Deposition; Diagnosis; Discrimination; Disease; Environment; Equity; Future; Genetic; Genetic study; Goals; Healthcare Systems; Heritability; Individual; Kenya; Latin American; Measurement; Measures; Mental Health; Mental disorders; National Institute of Mental Health; Obsessive compulsive behavior; Phenotype; Population; Population Heterogeneity; Procedures; Process; Property; Psychometrics; Reproducibility; Resources; Schizophrenia; Site; Standardization; Symptoms; Uganda; Underrepresented Populations; cognitive function; cohort; data archive; disease phenotype; instrument; member; phenotypic data; psychogenetics; severe mental illness; social stigma; suicidal; trait; working group

PROJECT SUMMARY This project actualizes a primary goal of the Ancestral Populations Network (APN; PAR-20-026 and PAR-20- 027), namely to facilitate measurement and data analytic harmonization efforts across APN members to enhance rigor and reproducibility and generate a resource for network members and the scientific community. Through a consensus process of APN members, measures of anhedonia, cognition, obsessive-compulsive symptoms, suicidality, and discrimination/stigma were selected for harmonization across ongoing studies. These harmonized measures will be collected across an estimated 27,500 individuals representing Asian, Latin American, and African ancestries spanning over 15 countries.

项目概要 该项目实现了祖先种群网络（APN；PAR-20-026 和 PAR-20- 027），即促进 APN 成员之间的测量和数据分析协调工作，以增强 严谨性和可重复性，并为网络成员和科学界提供资源。通过一个 APN成员的共识过程，快感缺乏、认知、强迫症状的测量， 选择自杀和歧视/耻辱来协调正在进行的研究。这些 将针对代表亚洲、拉丁裔的约 27,500 名个人收集统一措施 拥有美国和非洲血统，横跨 15 个国家。